Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"beta amyloid"”.
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Nanomaterials Self-Assembly Driven by Beta-Amyloid Peptides
… with several peptides derived from betaamyloid peptide. The peptides propensity to form fibrilar structures was exploited. The products obtained by aggregation of the peptides with the nano materials were studied using HPLC, UV-vis spectroscopy, TEM and optical light microscopy.
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Mechanistic insights into the aggregation of [beta]-amyloid
Many of the fundamental characteristics of amyloid formation are still unknown, largely due to the limitations present in currently available techniques. This is particularly problematic for disease-associated amyloid-forming species such as betaamyloid (A/3) , due to the tremendous impact that …
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Effect of cellular factors on the generation of beta-amyloid.
… including Alzheimer's disease (AD), light chain amyloidosis, spongiform encephalopathies, Huntingdon's disease, Parkinson's disease, etc. AD is a progressive neurodegenerative condition responsible for dementia in the elderly. An early onset, familial genetic basis (FAD) for the disease has been …
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Beta-Amyloid oligomeric and monomeric states: implications for Alzheimer's Disease
… a predominant idea refers to the crucial role of amyloid-beta protein (Abeta) in the pathogenesis of the disease; in fact, the feature in the brain of AD patients is the presence of extracellular plaques mainly composed of Abeta. Nevertheless, Abeta is physiologically produced in healthy …
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Angiotensin-converting enzyme cleavage of the Alzheimer's beta-amyloid peptide
… it has been shown that ACE hydrolyses the amyloid beta (Aβ) peptide, the putative causative agent of AD. This study aimed to investigate the molecular basis of ACE hydrolysis of Aβ by determining : 1) the kinetic parameters of five different forms of human ACE with various N-terminal …
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Cerebral Amyloid Angiopathy-Causing Beta-Amyloid Variants Have Altered Effects on the Clotting System
<p>Cerebral amyloid angiopathy (CAA), where beta-amyloid (Aβ) deposits around cerebral blood vessels, is a major contributor of vascular dysfunction in Alzheimer's disease (AD) patients. However, the molecular mechanism underlying CAA formation and CAA-induced cerebrovascular pathologies, including …
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[Beta]-amyloid-mediated nitric oxide release from rat microglia by ligation of the integrin Mac-1
… by a loss of neurons and an accumulation of [beta]-amyloid plaques, neurofibrillary tangles, dystrophic neurites, and reactive glial cells. While most previous studies on the neurodegeneration of AD have focused on neuronal cells and direct [beta]-amyloid-mediated neurotoxicity, few have …
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Aktivierung phagozytierender Zellen durch "Advanced Glycation Endproducts" und beta-Amyloid-Implikationen für die Pathogenese der Alzheimer'schen Demenz
… Plaques bestehen im Wesentlichen aus fibrillärem beta-Amyloid, das durch Glykierungen verändert vorliegen kann. Außerdem beinhalten die Plaques, sogenannte AGEs "Advanced Glycation Endproducts", die aus nichtenzymatisch glykierten Proteinen entstehen. Diese AGE-modifizierten Proteine sowie das …
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The Role of TNF Signaling in Regulating Beta-Amyloid Burden in the 3xTgAD Mouse Model of Alzheimer's Disease
… activity and halt or delay the early stages of amyloid-associated neuropathology. In vitro, cells infected with lenti-pro-DN-TNF-IRES-GFP produce sufficient levels of DN-TNF protein to block nuclear translocation of p65 in response to stimulation by TNF. Infection with lenti-DN-TNF also blocks …
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A New Role for Beta-Amyloid in Alzheimer's Disease: Initiation of Thrombotic and Inflammatory Processes Via Coagulation Factor XII and Fibrinogen
… and experimental evidence links the beta-amyloid (Aβ) peptide to disease onset and progression, the mechanisms behind neuronal dysfunction in AD are not completely understood. It is now clear that AD is a complex, multifactorial disease characterized by vascular dysfunction, …
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The Role of Metal Ions and Reactive Oxygen Species in beta-Amyloid Aggregation and Toxicity and Their Relevance to Alzheimer's Disease.
The aggregation and deposition of beta-amyloid (AB) in the brain has long been implicated in the neurotoxic pathways causing Alzheimer's disease (AD). Recent data suggests that early, soluble oligomers of Ap are the toxic species. Oxidative stress may be partly responsible for the toxicity of the …
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Relationships between psychosocial stress, cortisol, apolipoprotein є4, beta-amyloid, hippocampal volumes and Alzheimer's disease in a sample of South African older adults
… apolipoprotein E (APOE) genotype, and plasma beta-amyloid levels were determined at baseline.
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Conformational studies of the beta amyloid protein and in vitro models for the effects of apolipoprotein E on fibril formation in Alzheimer's disease
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1996.
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Regulation of BACE1 promoter activity by nuclear factor-kappaB\r\n
… cerebrovascular and parenchymal deposits of beta-amyloid peptides, which are derived by proteolytic processing of the amyloid precursor protein (APP). The beta-site APP-cleaving enzyme 1 (BACE1) is required for the generation of beta-amyloid peptides. The NF-kappaB binding DNA consensus …
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Investigating the process of fibril formation of the Iowa mutant of the Alzheimer's peptide
… this study is to determine how the length of the beta-amyloid peptide, the specific region of the peptide, and a single point mutation affect the behavior of Alzheimer’s beta-amyloid. The beta-amyloid peptide, which is a 40 residue peptide that has been implicated as a potential cause of …
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Role of MOA-1, an Anti-phosphatase, and APL-1, an APP-related Protein, in Morphogenesis and Mating Behavior in Caenorhabditis elegans
… by an accumulation of extracellular beta-amyloid peptide plaques and intracellular neurofibrillary tangles in the brain. The beta-amyloid peptide is derived from a larger precursor protein, the amyloid precursor protein (APP). Mutations in APP have been correlated with Alzheimer's …
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New Synthetic Polyamines as Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease and Cancer: Design, Synthesis and Biological Evaluation
… and inhibition of the aggregation of beta-amyloid). Therefore, the MTDL strategy seems a more appropriate approach for addressing the complexity of AD and may provide new drugs for tackling its multifactorial nature. In this thesis, it is described the design of new MTDLs able to …
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Identification of HIV protease mutants with improved specificities toward an Alzheimer's Disease associated peptide sequence
… activities toward an octapeptide taken from the beta-amyloid peptide (Abeta) implicated in Alzheimer's Disease. Quantitative Western blotting of E. coli extracts revealed approximately 20- and 30-fold increases in proteolytic specificity and activity, respectively, toward the Abeta octapeptide …
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A study of the elongation of fibrils of the Alzheimer's amyloid beta protein with a coarse-grained force field
… research points to a small protein, the beta-amyloid peptide (Abeta), as the first suspect. Ab chains are present in the brains of healthy individuals, but in AD patients, they associate and form clumps that deposit outside neurons, and are believed to trigger the disease. In this …
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Nicotinic acetylcholine receptors and their interaction with Aβ₁₋₄₂
… presence of neurofibrillary tangles and amyloid plaques. At present ~ 5 % of those aged over 65 years are diagnosed with AD, with this figure increasing to ~ 20 % for those aged over 75 years. It is nearly 100 years since AD was first characterised in 1907, however the exact cause has yet …
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