Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"beta adrenergic"”.
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Sex differences in the cardiac beta-adrenergic receptor contractile response
… difference is not present following menopause. &beta-adrenergic receptors are pharmaceutical targets in the treatment of cardiovascular disease, and sex differences in &beta-adrenergic responsiveness have been demonstrated. However, limited studies have addressed the mechanism(s) underlying these …
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Dhhc5 Regulates Beta-Adrenergic Signaling In The Heart Through Palmitoylation of G Alpha Proteins
… work in this dissertation investigated whether β-adrenergic stimulation led to stimulus-dependent palmitoylation of downstream signaling proteins in immortalized and primary cell models. I found that β-adrenergic stimulation led to rapidly increased Gαs and Gαi palmitoylation only in primary …
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Compound 49b: A Novel Beta-Adrenergic Receptor Agonist in the Treatment of Diabetic Retinopathy
… We have previously shown that a non-specific beta-adrenergic receptor agonist, isoproterenol, was effective in preventing functional and morphological changes associated with diabetic retinopathy in the rat. Isoproterenol also produced left ventricle remodeling suggesting it entered the …
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The Use of Albuterol, a Beta-Adrenergic Compound to Alter Fat and Muscle Deposition in Lambs
Several compounds called beta adrenergic agonists have been discovered which partition nutrients away from fat deposition and increment muscle accretion in poultry, swine, sheep and beef One beta-adrenergic compound ( albuterol) has never been researched on any meat producing animals. Therefore, …
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Diverse Immune Responses Mediated by Beta-Adrenergic and Corticotropin-Releasing Hormone Receptors in a Model of Pneumococcal sepsis
… CRH receptors (CRHR1 and CRHR2) as well as the 2 adrenergic receptor prior to restraint stress followed by intranasal pulmonary S. pneumoniae infection. Antagonist administration did not impact restraint stress-induced physiological responses as compared to restraint stressed mice, which did not …
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AIRWAY SURFACE HYPERVISCOSITY AND DEFECTIVE MUCOCILIARY TRANSPORT BY IL-17/TNF-ALPHA ARE CORRECTED BY BETA-ADRENERGIC STIMULUS
… of ENaC channel, ATP12A proton pump, ADRB2 β-adrenergic receptor, and SLC26A4 anion exchanger. The overall result of IL-17A/TNF-α treatment was hyperviscosity of the airway surface, as demonstrated by fluorescence recovery after photobleaching (FRAP) experiments. Importantly, stimulation with …
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Thrombolytic therapy and beta-adrenergic blockade in acute myocardial infarction : a prospective evaluation at Groote Schuur Hospital 1988-1990
… feasibility and safety of combining intravenous beta-adrenergic blockade with intravenous thrombolytic therapy in patients presenting with acute nyocardial infarction. 3. To assess the need for coronary angiography in all patients treated with thrombolytic agents for acute myocardial infarction. …
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Myocardial Contractility in Fetal Sheep Exposed to Long-term Hypoxia at High Altitude : Activator Calcium and Beta-adrenergic Receptor Function
… dihydropyridine (DHPR), ryanodine (RyR), and β-adrenergic receptor densities, and measured basal and stimulated intracellular cAMP levels. In hypoxic fetuses, left ventricular wet weight was unchanged, but right ventricular weight was ~20% lower than controls. Curves describing the …
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Effects of Pasteurella haemolytica on Pulmonary Vascular Adrenergic Mechanisms
… by disruption of the pulmonary vascular adrenergic system. However, only a limited amount of research has addressed the adrenergic system and its relationship to the etiology and pathophysiology of this disease. In an attempt to further investigate the contributions of the vascular …
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Behavioural assays of the effects of antidepressant drug treatment on the functioning of catecholamine systems
The effects of antidepressant drugs on central beta-adrenergic and dopaminergic receptor function were investigated using the anorexic effects of low doses of amphetamine and apomorphine as assays of beta-adrenergic function and presynaptic dopamine function respectively. Anorexia was typically …
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In Vitro studies of factors which may influence ligand binding, function, immunogenicity and genetic regulation of the Beta-2 adrenergic receptor in asthma
… ligand binding and functional activity of the beta-2 adrenergic receptor. These studies were prompted by previous reports that the postulated beta-2 adrenergic receptor abnormality in allergic asthma could be induced, induced by autoantibodies. I established and optimised beta-2 adrenergic …
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Sympathetic Innervation of the Rat Adrenal Cortex and Its Effects on the Compensatory Adrenal Cortical Growth Response to Unilateral Adrenalectomy (Catecholamine, Endocrine, Splanchnic Nerve, Cell Proliferation)
… growth was observed in animals treated with the (beta)-blockers propranolol (10 or 25 mg/kg) and Sotalol (25 or 50 mg/kg), although vehicle-injected animals failed to show the response. These results suggested that (beta)-adrenergic receptor blockade released a stress-related inhibition of the …
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A Study of the Action of Prostaglandin F2a on the Guinea-Pig Isolated Trachea
… was placed on considerations of the possible beta-adrenergic blocking activities of this essential fatty-acid derivative. | Experiments were performed using a 20 ml tissue bath and a modified phosphate-Tyrode solution. Measurements were made by an isotonic myograph and displayed on a …
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A Study of the Adrenergic Receptors in Mammalian Tracheal Smooth Muscle
Adrenergic receptors of mammalian tracheal smooth muscle have been characterized. After beta-adrenergic blockade with propranolol, the responses to epinephrine in both human and guinea-pig tracheal smooth muscle were contractile. These dose-dependent contractions were blocked with the …
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Network coherence in autism spectrum disorder : a multimodal neuroimaging study of functional connectivity and spectroscopy MRI
… clinical utility of altered network coherence. Beta-adrenergic antagonism improved information processing in a subset of individuals with ASD and improved performance was related to pharmacologicallymediated alterations in functional connectivity in the fronto-parietal control network. These …
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Role of Tyk2 in the Development of Beige Cells
… can emerge in WAT depots in response to cold or beta-adrenergic stimulation. These cells have been called “beige” or “brite” (brown-in-white) cells. The reduction of obesity in mice treated with beta-adrenergic agonists is correlated with the emergence of beige cells. Beige cell development …
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Effects of endocrine modifiers on growth, carcass characteristics, and blood and tissue metabolites of finishing beef cattle
… of vitamin A and the interaction of steroids and beta-adrenergic agonists on growth and carcass performance, tissue metabolite profiles, and lipogenic enzyme activity were evaluated in beef cattle. In 1 experiment steers were fed 1 of 5 supplemental levels of vitamin A (0, 1,103, 2,205, 4,410, or …
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