Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"berberine"”.
-
Precursor-directed biosynthesis of non-natural berberine and galanthamine analogues
… precursor analogues to produce fluorinated berberine and galanthamine analogues are 5-fluorodopmaine, 2-fluorodopamine, 3-fluorotyrmaine, and 5-fluoroprotocatechualdehyde. 5-Fluorodopamine is synthesized in 43% yield from 3-fluoroanisole and the crystal structure is reported. Progress …
-
Effect of berberine on in vitro metabolism of sulfonylureas: a herb-drug interactions study
… and prescribed to treat type 2 diabetes. Berberine is an active component of medicinal herbs and used by individuals to self-regulate the blood glucose levels. Around 8.5 million patients of type 2 diabetes were prescribed with sulfonylureas and 40-60% of general population use herbal …
-
Investigating the metabolic impact of Metformin and Berberine in combination with Venetoclax for Acute Myeloid Leukaemia treatment
… effects of Venetoclax combined with Metformin or Berberine, an herbal supplement with a similar mechanism of action to metformin, on AML cell death and metabolic changes. The combination of Metformin and Venetoclax (Met+Ven) showed a synergistic cell death response in the HL60 cell line, unlike …
-
The effects of herbal extracts and compounds on the glucose metabolism in Hep G2 cells
… with pure compounds phloretin, ouabain, berberine, and metformin, rebaudioside-A, and extracts of Stevia rebaudiana Bertoni, Hydrastis Canadensis L., Galega officinalis L., and Gymnema sylvestre (Retz.) R.Br. ex Sm. In the screening tests, changes in glucose uptake in response to …
-
Regulation of Cholesterol Biosynthesis in Hepatocytes
… human hepatoma cell line HepG2. One compound, berberine, showed great potential as a regulator of cholesterol synthesis and so became the subject of this investigation. Berberine inhibited HMG-CoA reductase activity and decreased cellular accumulation of cholesterol. Berberine was shown to …
-
In vitro studies on new therapeutic approaches for human thyroid cancer
… particular, it has been studied the effects of Berberine, an alkaloid that has been reported to have anticancer activities, on FTC-133 and 8305C cancer cell lines. Our results showed that TfR1 appeared expressed at high levels in both thyroid cancer cell lines, even if it was more evident in the …
-
Anti-breast cancer activity of Coptidis Rhizoma-Euodiae Fructus formulae
… Coptis-Euodia formulae, and standard alkaloids berberine and evodiamine, associated with their possible mechanisms as anti-cancer agent candidates. Thereby, a hypothesis of “Interaction and synergy between compounds might enhance, reduce, or even revise the bioactivities of medicinal herbs and …
-
Evaluation Of HIF Inhibitors For The Treatment of Ocular Neovascular Diseases
… about phytochemical molecules - honokiol and berberine and shows them to be potent inhibitors of the HIF pathway as well as hypoxiainduced expression of KDMs in a number of cancer and retinal pigment epithelial cell lines. The results provide an evidence-based scientific explanation for …
-
Engineering Complex Kidney Structures for Disease Modelling, Drug Testing, and Studying Kidney Development
… than other compounds and discovered that berberine possesses high therapeutic potential for PKD treatment. <br></br><br></br> Optimising the protocol and using different human iPSC lines, we successfully engineered functional human ureteric bud (UB)-like tubules capable of recapitulating …
-
Root adaptive responses of tall fescue (Festuca arundinacea) growing in sand treated with petroleum hydrocarbon contamination
… root sections were also stained with 0.1% (w/v) berberine hemisulphate in order to stain Casparian bands. Overlaying images obtained with the use of Texas red HYQ filter (wavelength 589-615nm) and UV illumination (wavelength 345-458nm) revealed the presence of passage cells in the endodermis and …
-
Isolierung, Identifizierung und Partialsynthese von Pflanzeninhaltsstoffen aus Croton flavens L.
… der Biosynthese aus Retikulin wird durch das "Berberine Bridge Enzym“ die N-Methylgruppe zur Cyclisierung oxidiert. Dies ist erst der zweite Bericht, dass Tetrahydroprotoberberine aus einer Croton-Spezies isoliert wurden. Fünf weitere Verbindungen gehören der Stoffklasse der Morphinandienone …