Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 62 for “"benzodiazepines"”.
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Benzodiazepines and Dopamine Mediated Behavior
… depleting lesions on behavior and the effects of benzodiazepines on catalepsy and the ventral tegmental area.
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Design and Synthesis of Novel Benzodiazepines
Bivalent drug design is an efficient strategy for increasing potency and selectivity of many drugs. We devised a strategy to prepare agonist-benzodiazepine heterodimers that could simultaneously bind to agonist and BZD sites of the GABAAR. We synthesized a benzodiazepine-MPEG model compound that …
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Two-Part Reactive Formulations for Intranasal Delivery of Benzodiazepines
… damage and other life-threatening complications. Benzodiazepines are the primary rescue medications used to treat seizure emergencies, the most commonly used being intravenous lorazepam or rectal diazepam. Despite the effectiveness of these drugs, the delivery routes are not ideal for first-line, …
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Substance misuse in young people in Ireland - a focus on benzodiazepines
Benzodiazepines are a class of drugs that are prescribed for the treatment of anxiety and insomnia. Due to the powerful tolerance that can develop as a result of sustained use, benzodiazepines can also be dependence-forming. Benzodiazepine dependence can occur from prescribed and from recreational …
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Assessing Concurrent Use of Opioids and Benzodiazepines Using Urine Drug Test Results
… dissertation was to assess concurrent use of benzodiazepines and opioids, using laboratory results from urine toxicology records. The opioid crisis is an ongoing public health issue that has spanned over two decades. Drug overdose death is now the leading cause of accidental deaths among …
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Combinatorial approach to multi-substituted 1,4-Benzodiazepines as novel non-peptide CCK-antagonists
… process, a library of 168 multisubstituted 1,4-benzodiazepines were prepared by a 5-step solid phase combinatorial approach. Substituents were varied in the 3,5, 7 and 8-position on the benzodiazepine scaffold. The combinatorial library was evaluated in a CCK radiolabelled binding assay and CCKA …
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Association of incident gabapentin use: with long-term use of opioids, benzodiazepines and Z-drugs
… when taken with other drugs, such as opioids, benzodiazepines (BZD) and Z-drugs. Although gabapentin is considered safe when used alone, concomitant use with the aforementioned drugs is dangerous and increases the risk of overdose. The aim of this research was to investigate the association …
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A retrospective review of the utilization of Benzodiazepines and Z-drugs in selected private community pharmacies in Namibia: 2017-2022
ackground: Overuse of benzodiazepines and Z-drugs is a considerable global public safety concern. In Namibia, despite the rising burden of mental illnesses, there is a paucity in data regarding the utilization of benzodiazepines and Z-drugs. Aim: The study aimed to determine the patterns and …
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Benzodiazépines et thérapie cognitive-comportementale transdiagnostique de groupe pour les troubles anxieux : une étude mixte
… one of the most common mental health disorders. Benzodiazepines are also commonly used but should be prescribed as a second-line treatment, in the short term, and as an adjuvant to an evidence-based treatment. When starting CBT, it is frequent for people living with an anxiety disorder to already …
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Development and partial validation of a method for the quantification of benzodiazepines and antidepressants in whole blood, serum and urine by liquid chromotography - Tandem mass spectrometry
… a single quantification method for certain benzodiazepines, opiates and antidepressants in whole blood, serum and urine by LC-MS/M5 and to consequently validate the analytical method for official use in the Division of Pharmacology at the University of Cape Town.
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Design and Syntheses of Potential Drugs Based on GABA(A) Receptor Pharmacophores
… to be as potent as GABA. In our studies of 1,4-benzodiazepines, our goal was to synthesize three different subtypes of quaternary 1,4-benzodiazepines by use of the memory of chirality (MOC) strategy. Disappointingly, most of the deprotonation/alkylations failed, due to various reasons. The …
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Investigating excitatory GABAergic signalling & benzodiazepine resistance in an in vitro model of status epilepticus
… status epilepticus uses a group of drugs, the benzodiazepines, that promote the action of the major inhibitory neurotransmitter within the brain, gamma (γ)-aminobutyric acid (GABA). In a subset of patients however, benzodiazepines prove to be ineffective in terminating SE. Previous data from in …
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Memory of Chirality in 1,4-Benzodiazepin-2-ones
… to enantiomerically enriched 3,3-disubstituted benzodiazepines containing a "quaternary" stereogenic center. This research will discuss the stereochemical properties of 1,4-benzodiazepin-2-ones, and provide a novel approach to synthesize enantiomerically enriched "quaternary" benzodiazepines …
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The synthesis and pharmacology of gamma-aminobutyric acid receptor mimetics
… in Triton X-lOO treated membranes. A series of benzodiazepines were shown to displace 3H-Isoguvacine bound to frozen-thawed rat synaptosomal membranes. This effect was shown to be temperature-dependent and could be blocked by picrotoxinin (10-4 M). Pentobarbitone was also seen to displace …
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Factors Associated with Wean Duration Length as a Measure of Iatrogenic Withdrawal Syndrome in the Neonatal Intensive Care Unit: A Retrospective Chart Review
… Intensive Care Unit (NICU) receive opioids and benzodiazepines for reasons including surgical procedures and mechanical ventilation. Neonates who are exposed to high doses of opioids and benzodiazepines for prolonged periods of time, are at an increased risk of iatrogenic withdrawal syndrome …
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Pharmacological and Non-pharmacological Prevention of Fentanyl-Induced Cough : A meta-analysis
… atropine [OR = 1.10, 95% CI 0.58 – 2.11] and benzodiazepines [OR = 2.04, 95% CI 1.33 – 3.13] were not effective. This meta-analysis found that lidocaine, NMDA receptor antagonists, propofol, α2 agonists, β2 agonists, and priming dose of fentanyl were effective in preventing FIC, but atropine …
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Screening and mitigation of anxiety in unique environments
… Medication countermeasures consisting of benzodiazepines may quell in-flight anxiety, but do not likely improve anxiety on repeat exposure. The scarce available literature addressing anxiety in unique environments indicates that training/repeated exposure may mitigate anxiety. Anxiety and …
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Management of Treatment-Resistant Schizophrenia
… different generic forms, the use of Clozapine, benzodiazepines, cognitive behavioral therapy, psychotherapy and social therapy.
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Analytical separations using packed and open-tubular capillary electrochromatography
… this research involves the separation of seven benzodiazepines by the use of the packed mode of capillary electrochromatography (CEC) and a 40 cm packed bed of Reliasil 3 μm C<sub>18</sub> stationary phase. Optimal conditions were established by varying the mobile phase, the amount of organic …
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