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Showing 1 to 20 of 49 for “"benzodiazepine"”.

  1. Benzodiazepine and opioid dependence. Clinical and meta-analytical studies.

    Johansson, Björn AxelClinical Alcohol Research, Department of Health Sciences, Lund University2006

    The thesis contains 4 papers, two clinical studies and two meta-analyses. In the BZD taper study (Paper I) 21 BZD dependent (DSM-IV) patients were included for a 10-day inpatient detoxification. The average defined daily dose (DDD) was 4.7 doses. Withdrawal symptoms were not more pronounced …

    lund Repository record

  2. Norms, attitudes, perceptions, and intentions for benzodiazepine prescription drug abuse among adolescents

    O'Neill, Angela K.2012

    … of adolescents’ behavioral intentions for benzodiazepine abuse. Subjective norms, perceived harm, and perceived behavioral control were measured to predict intentions to abuse such drugs. Similar measures for alcohol and marijuana also were assessed for comparison purposes. A survey was …

    emich Repository record

  3. Liganden des Benzodiazepin-Rezeptors: Studien über Benzodiazepine in pflanzlichen Geweben sowie über Hispidulin

    Kavvadias, DominiqueUniversität Würzburg

    … Der erste Teil war dem Studium „natürlicher“ Benzodiazepine (BZD) gewidmet. Deren Vorkommen ist vielfach belegt; an ihrer Biogenese sind möglicherweise Mikroorganismen beteiligt. Es war nun zu prüfen, ob BZD auch unter Sterilbedingungen, d.h. nach Ausschluss mikrobieller Aktivität auftreten …

    wurz-thes Repository record

  4. Investigating excitatory GABAergic signalling & benzodiazepine resistance in an in vitro model of status epilepticus

    Burman, Richard JDivision of Medical Biochemistry and Structural Biology2018

    … status epilepticus uses a group of drugs, the benzodiazepines, that promote the action of the major inhibitory neurotransmitter within the brain, gamma (γ)-aminobutyric acid (GABA). In a subset of patients however, benzodiazepines prove to be ineffective in terminating SE. Previous data from in …

    cape-town Repository record

  5. THE CHARACTERIZATION AND REGULATION OF BENZODIAZEPINE BINDING SITES IN THE MAMMALIAN RETINA, CEREBRAL CORTEX AND KIDNEY

    Regan, John WardThe University of Arizona.1981

    The binding of [³H]flunitrazepam (FLU) to membranes prepared from mammalian brain, retina and kidney was investigated by means of conventional filtration assay techniques. In the mouse brain a study of the ontogeny of [³H]FLU binding was conducted. Specific [³H]FLU binding was present early in …

    arizona-thes Repository record

  6. Substance misuse in young people in Ireland - a focus on benzodiazepines

    Murphy, Kevin D.University College Cork2014

    Benzodiazepines are a class of drugs that are prescribed for the treatment of anxiety and insomnia. Due to the powerful tolerance that can develop as a result of sustained use, benzodiazepines can also be dependence-forming. Benzodiazepine dependence can occur from prescribed and from recreational …

    cork Repository record

  7. What is the relationship between attachment difficulties, alexithymia, and substance misuse? A systematic literature review. And Investigating the relationship between alexithymia, depression, and problematic benzodiazepine use.

    Sophie Coles (21043979)2026

    … between alexithymia, depression, and problematic benzodiazepine use. Background: Benzodiazepines are a class of sedative and anxiolytic drugs. Benzodiazepines are commonly prescribed in the United Kingdom for physical and mental health difficulties but are also widely used recreationally. When …

    exeter

  8. Subjective sleep quality in the elderly: relationship to anxiety, depressed mood, sleep beliefs, quality of life, and hypnotic use

    Galea, MelissaVictoria University2008

    … were self reported poor sleepers, with 21 using benzodiazepine hypnotic medication regularly and 31 not using hypnotics. The measures used included the Pittsburgh Sleep Quality Index (PSQI), Geriatric Depression Scale (GDS), The Beck Anxiety Inventory (BAI), Sleep Beliefs Questionnaire (SBQ), and …

    vu-aus Repository record

  9. Effect of Zolpidem, Zaleplon, and Ramelton on cognitive functioning after awakening from napping

    RIchard W. ColeThe University of Texas Medical Branch2008

    Non-benzodiazepine sedative hypnotics and melatonin receptor agonist hypnotics induce the onset of sleep and are primarily prescribed for the treatment of insomnia. Although, non-benzodiazepine sedative hypnotic drugs zaleplon (Sonata) and zolpidem (Ambien) are not chemically like benzodiazepines, …

    utmb Repository record

  10. Two-Part Reactive Formulations for Intranasal Delivery of Benzodiazepines

    Rautiola, Davin2019

    … damage and other life-threatening complications. Benzodiazepines are the primary rescue medications used to treat seizure emergencies, the most commonly used being intravenous lorazepam or rectal diazepam. Despite the effectiveness of these drugs, the delivery routes are not ideal for first-line, …

    umn Repository record

  11. Design and Synthesis of Novel Benzodiazepines

    MacQuarrie, Stephanie LeeVirginia Tech2005

    … drugs. We devised a strategy to prepare agonist-benzodiazepine heterodimers that could simultaneously bind to agonist and BZD sites of the GABAAR. We synthesized a benzodiazepine-MPEG model compound that relied on physiological GABA to elicit flux. We established that a tether at the N1 position …

    vt Repository record

  12. An Analysis of the Opioid Crisis in Nevada

    DeVore, Deena2019

    … the presence of a combination of an opioid and benzodiazepine within a one-month period, the presence of an opioid, benzodiazepine, and muscle relaxer within a one-month period, receiving prescriptions for more than seven consecutive months within a year, receiving prescriptions that exceeded 90 …

    unr Repository record

  13. Combinatorial approach to multi-substituted 1,4-Benzodiazepines as novel non-peptide CCK-antagonists

    Offel, MichaelAston University2001

    … process, a library of 168 multisubstituted 1,4-benzodiazepines were prepared by a 5-step solid phase combinatorial approach. Substituents were varied in the 3,5, 7 and 8-position on the benzodiazepine scaffold. The combinatorial library was evaluated in a CCK radiolabelled binding assay and CCKA …

    aston Repository record

  14. Assessing Concurrent Use of Opioids and Benzodiazepines Using Urine Drug Test Results

    Taha, Shaden 1989-The University of Texas Medical Branch at Galveston2022

    … dissertation was to assess concurrent use of benzodiazepines and opioids, using laboratory results from urine toxicology records. The opioid crisis is an ongoing public health issue that has spanned over two decades. Drug overdose death is now the leading cause of accidental deaths among …

    utmb Repository record

  15. The synthesis and evaluation of small organic molecules as cholecystokinin antagonists

    Singh, HarjitAston University2002

    … alternative chemical approaches developed. 1,4-Benzodiazepine analogues were prepared, with substitutents In the 1,2 & 3- position of the benzodiazepine scaffold varied, and substituted 3-anilino benzodiazepines exhibited the greatest in vitro activity towards the CCKA receptor subtype. Through …

    aston Repository record

  16. The long-term effects of reproductive experience on the neurobiology of anxiety and its treatment: a cross species approach in female rats and women

    Pestana, Jodie ; https://orcid.org/0000-0002-2374-9685UNSW, Sydney2023

    … that the estrous cycle impacted diazepam (a benzodiazepine) sensitivity in nulliparous rats, but not primiparous rats. Chapter 4 compared the effects of chronic fluoxetine (an SSRI, the first-line pharmacological treatment for anxiety disorders) in nulliparous versus primiparous rats. …

    unsw Repository record

  17. The synthesis and pharmacology of gamma-aminobutyric acid receptor mimetics

    McDonald, Jane Anne MargaretCity of London Polytechnic1981

    … to act as a mixed agonist/antagonist at the GABA-benzodiazepine receptor complex. The binding of 3H-Isoguvacine to frozen-thawed, rat brain synaptosomal membranes has been investigated and found to be saturable, specific and stereospecific. The pharmacology of this 3H-Isoguvacine binding site was …

    london-metro Repository record

  18. Benzodiazépines et thérapie cognitive-comportementale transdiagnostique de groupe pour les troubles anxieux : une étude mixte

    Durand, CamilaUniversité de Sherbrooke2021

    … one of the most common mental health disorders. Benzodiazepines are also commonly used but should be prescribed as a second-line treatment, in the short term, and as an adjuvant to an evidence-based treatment. When starting CBT, it is frequent for people living with an anxiety disorder to already …

    sherbrooke Repository record

  19. Dementia Risk in Elders with Anxiety and Insomnia

    Wallis, Richard DavidThe University of Texas Medical Branch at Galveston2018

    … suggests that there is an association between benzodiazepine-receptor-agonist medications (BZRA) and subsequent dementia. Expert opinions differ regarding whether the association indicates a causal relationship. There is sufficient evidence that neuropsychiatric symptoms, such as anxiety and …

    utmb Repository record

  20. Dementia Risk in Elders with Anxiety and Insomnia

    Wallis, Richard DavidThe University of Texas Medical Branch at Galveston2019

    … suggests that there is an association between benzodiazepine-receptor-agonist medications (BZRA) and subsequent dementia. Expert opinions differ regarding whether the association indicates a causal relationship. There is sufficient evidence that neuropsychiatric symptoms, such as anxiety and …

    utmb Repository record

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