Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 74 for “"benzo(a)pyrene"”.
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Effect of Dietary Factors on Mutagenesis, Metabolism, and Binding to DNA of Benzo [a] pyrene and Benzo [a] pyrene 7, 8-dihydrodiol
… inhibited rat liver S9 protein dependent benzo[a]pyrene (B[a]P)-induced mutagenesis in Salmonella typhimurium TA 100 by 30-81% and B[a]P 7,8-dihydrodiol (DHD)-induced mutagenesis by 29 to 75%. EA (5-40 juM) did not significantly affect the metabolism of B[a]P or B[a]P 7,8-DHD as determined …
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Benzo[a]pyrene effects on Fundulus heteroclitus reproductive endpoints
Benzo[a]pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) that modulates aromatase enzyme function and, thus, potentially interrupts normal reproductive function. The aim of this study was to use a fish model, Fundulus heteroclitus, to assess whether BaP exposure adversely impacted …
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The metabolic fate of benzo [a] pyrene in vivo
[³H]-B[a]P absorption, distribution, metabolism, excretion and macromolecular binding in male Sprague-Dawley rats were investigated following administration by intratracheal instillation through a cannula. [³H]- radioactivity in various organs was determined at timed intervals between 5 and 360 …
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Benzo(a)pyrene control and transport processes in smoke meat products
… del proceso de ahumado, y el contenido máximo de benzo(a)pireno (BaP) (un marcador de la presencia y efecto de HAP en alimentos), se fijó en 5 ppb (¿g/kg), y se redujo a 2 ppb (¿g/kg) desde el 1/9/2014, por los reglamentos europeos No.1881/2006 y 835/2011, respectivamente. En esta tesis doctoral, …
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Effects of benzo[a]pyrene and CYP19a1b knockdown on zebrafish development
<p>Benzo[a]pyrene (BaP) is a ubiquitous environmental contaminant that is both an endocrine disruptor and a carcinogen. Aromatase (CYP19) is a key enzyme in steroidogenesis playing a key role in the hypothalamus-pituitary-gonad feedback loop. We hypothesized that BaP would negatively impact …
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DNA adducts as molecular biomarkers of exposure to benzo(a)pyrene
Thesis (Ph. D.)--Massachusetts Institute of Technology, Division of Toxicology, 1997.
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Laboratory study of the atmospheric heterogeneous oxidation of benzo[a]pyrene
… The heterogeneous reaction of particle-phase benzo[a]pyrene (BaP) with atmospheric oxidants ozone (O₃) and hydroxyl radical (OH) was investigated by simulating atmospheric conditions in a laboratory environmental chamber and measuring the particle-phase species with an Aerodyne Mass …
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Epigenetic effects of benzo(a)pyrene in Fundulus heteroclitus and Danio rerio
… and Danio rerio (zebrafish), to study the benzo(a)pyrene (BaP) effects on DNA methylation status and whether the alterations could contribute to BaP-mediated reproductive and developmental toxicities. Initially, we used Fundulus to study BaP effects on glycine N-methyltransferase (GNMT) …
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Quantification of benzo[a]pyrene-diol-epoxide adducts by laser-induced fluorescence spectroscopy
… LIF instruments were used to quantify adducts of benzo[a]pyrene-7,8-diol-9,10- epoxide (BPDE) in human lung tissue and human bronchial epithelial cell histones and DNA and in human serum albumin. The presence of BPDE adducts in human lung tissue and human bronchial epithelial cell histones and DNA …
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Alteration of differentiation and growth of normal human epidermal keratinocytes by benzo[a]pyrene and arsenic
… of four petroleum-derived hydrocarbons [benzo[a]pyrene (BaP), carbazole, dibenzothiophene, and isoquinoline] was investigated using the MTT assay; however, the research direction changed to focusing on examining the cellular effects, in NHEK, of BaP, the most toxic and carcinogenic …
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Effect of dose and dose rate on benzo[a]pyrene induced mutational spectra in human cells
Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Civil Engineering, 1994.
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Investigation into the effects of the tobacco smoke procarcinogen benzo[a]pyrene on gene expression profiles in oesophageal cancer
… of oesophageal squamous cell carcinoma (OSCC). Benzo[a]pyrene (BaP) is a tobacco smoke procarcinogen that is metabolically activated into the carcinogenic benzo[a]pyrene diol-epoxide (BPDE) by the CYP1 family of cytochrome P450 enzymes. BaP is a ligand for the aryl hydrocarbon receptor (AhR) …
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New insights into the mechanism of dna replication on unmodified and benzo[a]pyrene modified templates using surface plasmon resonance
… selection. </p> <p> Bulky DNA adducts such as benzo[a]pyrene interfere with replication by forming structures within the polymerase that preclude the productive binding of dNTPs, and/or inhibit this conformational change. Surface plasmon resonance was used to study the effect various dNTPs have …
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Y-family DNA polymerase architecture: three structural features control accurate deoxy CTP insertion opposite N2-deoxy-guanine-benzo-a-pyrene
… N2-dG adducts, including BP-N2-dG formed from benzo[a]pyrene (BP). Another class includes hDNAP h, EcDNAP V and SsDpo4, which insert accurately opposite UV-damage. For correct Watson-Crick pairing between BP-N2-dG and dCTP, the BP moiety must be in the minor groove. On the minor groove side of …
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Induction and characterization of de novo methylation by benzo[A]pyrene in the cancer cell lines MCF-7 and MDA-MB-231
… the hypothesis that the well-known carcinogen, benzo[a]pyrene has epigenetic effects, specifically the ability to alter cytosine methylation patterns. MCF-7 and MDA-MB-231 human breast cancer cells were treated for a period of sixty days with 100 nM benzo[a]pyrene. The methylation status of two …
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The removal of carcinogenic polycyclic aromatic hydrocarbons by activated sludge
Benzo-a-pyrene, a carcinogenic polycyclic aromatic hydrocarbon, was injected into the aeration tank of an activated sludge pilot plant in an investigation to determine the ability of activated sludge to effectively treat this compound. The method employed to segregate Benzo-a-pyrene from other …
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The synthesis of some new aromatic polycyclic hydrocarbons
In 1933, benzo[a]pyrene, a hydrocarbon, which was and still is of very great importance for cancer research, was isolated from coal tar and also was synthesized. In recent years more than 450 synthetic compounds have been found to be carcinogenic, and more than 200 are polycyclic aromatic …
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P-glycoprotein and membrane permeability as determinants of xenobiotic bioavailability and bioaccumulation
… tetracycline and ivermectin, and the carcinogen benzo[a]pyrene in catfish. The pesticide dieldrin and surfactant linear alkylbenzene sulfonate (LAS) were selected as mixture components thought to have potential interactions with these determinants of disposition. Initial in situ experiments …
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Combustion emissions from conventional boiler firing coal and tire derived fuel
… the presence of benzene, chrysene, phenol, and benzo(a)pyrene. Particulate emissions resulting from the combustion of 0, 10 and 20 percent tire mixtures with coal were 0.88, 2.32, and 2.13 lb/10⁶ Btu, respectively. For carbon monoxide, the emissions were 0.17,0.22, and 0.33 1b/10⁶ BTU for 0, 10, …
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