Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"benzamidine"”.
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Synthetic strategies for potential trypanocides
… selectively concentrates compounds that contain benzamidine and diaminotriazine P2 motifs, which can enhance the potency and selectivity of these compounds. The sleeping sickness drugs melarsoprol and pentamidine contain P2 motifs. Compounds comprising a P2 targeting motif, a linker and a …
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The penetration protease of the cercariae of Schistosoma mansoni
… such as soy bean trypsin inhibitor, trasylol or benzamidine inhibited the enzyme to a lesser degree. The active-site labels, TLCK, TPCK and AcAAAACK of trypsin, chymotrypsin and elastase respectively had no effect. Calcium and magnesium stimulated protease activity at concentrations below 0,5 mM, …
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1,1-enediamines and β-substituted enamines in heterocyclic synthesis
… enamines with two different amidines. When benzamidine was used, the expected pyrimidines were obtained. But, when 2-benzyl-2-thiopseudourea (which is also an amidine) was used, of the two expected pyrimidines, only one was obtained. In the other case, an additional substitution reaction …
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Purification of Two Myosin -Degrading Proteases From Porcine Skeletal Muscle
… serine protease was inhibited by DFP, aprotinin, benzamidine, soybean trypsin inhibitor, antipain, leupeptin and beta-mercaptoethanol, but not altered by E-64, pepstatin, or EDTA. Using radiolabeled DFP, a protein with Mr 32,000 was identified on an SDS gel as a DFP-binding protein, which was …
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Characterization of a plasminogen activator from human melanoma cells cultured in vitro
… partially purified by affinity chromatography on benzamidine-sepharose. This preparation was used to prepare rabbit antisera to the enzyme. These antibodies inhibited the activity of plasminogen activators released by all melanoma cells but had no effect on urokinase. Antibodies to urokinase had …
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Methods for increasing model accuracy and simulation time scales of biological processes with molecular dynamics
This dissertation presents three research projects on novel methods in computational bio- physics. Each of these projects introduces methodologies to extend the capabilities of molecular dynamics simulations in one way or another. In the first chapter, molecular dynamics simulations and the central …