Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"benign tumours"”.
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Developing Fluorescent Tools to Dissect the Role of Tuberin at Mitotic Onset
… Sclerosis is a genetic disorder that causes benign tumours to form in the kidneys, brain, skin, and other organs. This disease is caused by inactivating mutations in either the TSC1 or TSC2 gene encoding for Hamartin and Tuberin, respectively. Mechanistically, Hamartin and Tuberin form a …
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Patients presenting to primary and secondary care with dermatological conditions in south-east Scotland with reference to the dermatological training of general practitioners
… accounted for 22.5 %, infections 20.3 %, and benign tumours for 11.4% of consultations with a dermatological basis. In contrast, in secondary care, benign tumours accounted for 23.8 %, malignant tumours 16.4% and eczema 16.3% of dermatological consultations. Dermatological disorders make up a …
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Flexible Radial Data Acquisition and Image Reconstruction Strategies for Breast Magnetic Resonance Imaging
… have difficulty distinguishing malignant from benign tumours, resulting in low positive predictive values (on average, PPV = 45%). The research in this thesis is motivated by the need for improvement in the ability of MRI to differentiate breast lesions. It is believed that the differentiation …
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Mathematical Modelling of Cancer Growth and Spread: The Role of Matrix Metalloproteinases
… that grow without normal bounds is termed a benign tumour if it does not invade locally into the tissue and malignant when it invades into its surrounding tissue. Benign tumours are often harmless unless the pressure they exhibit onto the tissue surrounding it causes trouble to the …
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Characterization of endothelial cells of lymphatic vessels
… of blood and lymphatic vessels. In mice only tumours of the blood vessel endothelium (haemangiomas) have been thus far reported. In the first part of this thesis is described a highly reproducible method for the induction of benign tumours of the lymphatic endothelial cells (lymphangioma) in …
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The Role of Hippo Signalling in Merlin Null Tumours of the Nervous System
Meningiomas and schwannomas are mostly benign tumours of the nervous system that currently have no clinically approved treatments apart from surgical resection. The tumour suppressor Moesin-Ezrin-Radixin-Like Protein (Merlin) is deleted in 50-60% and 70% of meningiomas and schwannomas respectively. …
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The expression and role of Migration Stimulating Factor (MSF) in oral tumours
… remains very poor. The expression of MSF in oral tumours has not been previously reported.<br/><br/>The aims of this study were:<br/>• To determine the effects of MSF on the migration of oral tumour cell lines and normal stromal cells in culture (chapter 3),<br/>• To ascertain the possible …
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Expression and role of the extracellular matrix protein tenascin in ovarian cancer
… in the stroma of several types of malignant tumours. The expression of TN in ovarian cancer has not previously been investigated. The aims of the project were therefore to (i) define the expression of TN in ovarian cancer, (ii) examine factors controlling its production and (iii) explore the …
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Characterising DNA methylation in tissue and liquid samples from patients with renal tumours
… a variety of potential diagnoses, including benign and malignant tumours, the most common of which is clear cell RCC (ccRCC). Current methods are unable to confidently distinguish pathological subtypes of SRMs, meaning patients with benign tumours are undergoing unnecessary invasive surgery. …
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Infantile Haemangiomas: Epidemiological Characteristics and Management Approach // Хемангиоми в кърмаческа и детска възраст – епидемиологични характеристики и терапевтично поведение
Хемангиомите са най-често срещаните доброкачествени тумори при деца на възраст до 1 година, като засягат приблизително 4-5 до 10% от родените в нормална гестационна възраст и до 30% от недоносените кърмачета. Характеризират се с три добре отграничени фази на развитие с различни клинични …
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Role of two genes, CACNA1D and CADM1, with common or rare mutations in aldosterone producing adenomas of the adrenal.
… of aldosterone-producing adenomas (APAs). These benign tumours develop in the cortical region of adrenal glands and autonomously secrete excessive amounts of aldosterone. This hormone increases sodium retention and water reabsorption by the kidneys, leading to high blood pressure. Landmark …