Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"beige adipocytes"”.
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Exploring the Multifaceted Life of Beige Adipocytes
… While excess accumulation of lipid-storing white adipocytes is usually associated with metabolic complications, brown and beige adipocytes, specialized cell types that disspate energy through heat production, are associated with beneficial outcomes, including increased energy expenditure, improved …
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Unraveling the Interaction Between Beige Adipocytes and the Sympathetic Nervous System
… of obesity and its sequelae. While white adipocytes store excess energy, thermogenic brown and beige adipocytes convert lipids and glucose into heat, thereby increasing energy expenditure. Unlike classical brown adipocytes which are thermogenic under basal conditions, inducible brown …
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The Functional Cellular Identity and Interconversion of Human White, Beige, and Brown Adipocytes
… in the form of increased energy expenditure in adipocytes form the core of this therapeutic potential, little is known about the metabolic differences between white and brown adipocytes, as well as the thermogenic beige adipocytes arising within white adipose tissue upon stimulation, and this …
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Cold-Induced Metabolic Changes in Lean, NAG-1 Transgenic Mice
… causes an upregulation of thermogenesis in brown adipocytes and beige adipocytes, which is white adipose tissue that “browns” and becomes metabolically active. In this study, transgenic mice that constitutively express the human non-steroidal anti-inflammatory gene 1 (NAG-1) were used as a model …
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Anti-Obesity Effects of Adipose-Targeting Resveratrol Nanocarriers
… and weight gain occurs. Since induced brown-like/beige adipocytes have the same thermogenesis and metabolic sink functions as classical brown adipocytes, browning subcutaneous white adipose tissue (WAT) might be a practical and efficient approach for combating obesity. Trans-resveratrol (R) has an …
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Dissecting NAMPT Signaling Pathways in Beige Adipocyte Development, Impairment and Maintenance
… reduce the abundance and function of thermogenic beige and brown adipocytes, lowering energy expenditure and worsening metabolic disease. Beige adipocytes arise within white adipose tissue in response to environmental and hormonal cues, whereas brown adipose tissue is a dedicated thermogenic …
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Carnosic acid against insulin resistance and obesity. Investigating its effects on adipocytes.
… transdifferention of WAT into brown-like or beige adipocytes, which exhibit the same functional properties as BAT. Browning of WAT is an attractive approach against obesity and insulin resistance. In addition, evidence indicate that activation of the energy sensor AMP-activated protein kinase …
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Uncovering Regulators of Whole-Body Metabolism by Chemoproteomic Profiling of the Adipocyte Secretome
… and many types of cancers. Whereas white adipocytes efficiently store energy in the form of triglycerides, thermogenic brown and beige adipocytes can dissipate energy into heat. Adipose tissue is now considered an important endocrine organ, and increasing evidence suggests that divergent …
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Exploring the metabolic role of GPR30 in mice
… enhanced adipogenic differentiation of 3T3-L1 preadipocytes. For the second project, I explored whether estrogen acts through GPR30 to affect adiposity in female mice. For this study, I generated and examined three independent transgenic mouse models, aromatase (Ar) knockout (ArKO) mice, GPRKO, …
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ISG15 conjugation : cellular targets and the lysine selectivity of HERC5
… recently shown that glycolytic enzymes in mouse adipocytes were heavily ISGylated, and that ISGylation of LDHA suppressed thermogenesis in beige adipocytes. This study also showed that ISG15-null mice were resistant to diet-induced obesity, which has important implications for development of …