Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 23 for “"behavioral phenotype"”.
-
Aggressive Behavioral Phenotype in Intrauterine Growth Restricted (IUGR) Baboons Exposed to Moderate Nutrient Restriction Early in Development
The thrifty phenotype hypothesis proposes reduced nutrition alters the trajectory of development of metabolic regulatory systems to produce a phenotype better fitted to an environment of decreased later-life nutrient availability. Because organisms have physiological mechanisms for coping with poor …
-
THE CHARACTERIZATION OF BEHAVIORAL ABNORMALITIES IN BDNF LOXP TRANSGENIC MICE
… characterization and description of its behavioral phenotype. We utilized a three-stage behavioral protocol which included home cage monitoring observations, open-field, tail suspension, and acoustic PPI to provide a detailed behavioral phenotype for BDNF<sup> lox+/+</sup> mice. Tail …
-
cGMP -Dependent Protein Kinase, Behavioral Plasticity, and Foraging in Honey Bees and Fruit Flies
Here I describe a study of comparative behavioral genetics of a complex behavioral phenotype that is affected by a gene encoding a cGMP-dependent protein kinase (PKG, foraging). I accomplish this by using a traditional genetic model---the fruit fly, Drosophila melanogaster , and a traditional …
-
A vitamin D enriched diet attenuates sex-specific behavioral deficits in the NS-Pten knockout mouse.
… D enriched diet had a significant impact on the behavioral phenotype and survivability of NS-Pten KO mice.
-
Recursive Behavior Recording: Complex Motor Stereotypies and Anatomical Behavior Descriptions
A novel anatomical behavioral descriptive taxonomy improves motion capture in complex motor stereotypies (CMS) by indexing precise time data without degradation in the complexity of whole body movement in CMS. The absence of etiological explanation of complex motor stereotypies warrants the …
-
Developmental Trajectories of Effortful Control In Young Boys With Fragile X Syndrome
… as they contribute to the understanding of the behavioral phenotype of FXS by showing individual differences exist and need to be taken into account for each child when developing and implementing treatment.</p>
-
Semantic and pragmatic language development in typical acquisition, autism spectrum disorders, and Williams syndrome with reference to developmental neurogenetics of the latter
… language proceeds from identification of precise behavioral phenotypes to investigation of the underlying genes. The human behavioral parts of this dissertation focus on understanding the reasons for children's overuse of definite article 'the', to refer to one of several objects in a context set, …
-
The role of Substance P and its signaling pathways in central sensitization
… horn neurons is an underlying mechanism of behavioral phenotype, such as secondary hyperalgesia. Substance P (SP) is regarded as an important neuropeptide and mainly exists in primary afferent fibers in the superficial dorsal horn. Release of SP in the dorsal horn can be triggered in …
-
Cell-Type Specific Translational Profiling in Huntington's Disease Mouse Models
… (Heiman et al, 2008). We re-characterized the behavioral phenotype of the HD model mice on the D1 and D2 TRAP backgrounds and found many changes in the translated mRNA profiles of these two classes of medium spiny neurons, including known changes in the literature as well as novel pathways. One …
-
Sensory Neurogenesis and the Role of PRDM12 in Nociceptor Development and Function
… causes defects in nociception, but no behavioral phenotype was readily discernible following adult knockout. Instead, I show that Prdm12 appears to regulate a population of stem cell-like neurons, with an as-yet unknown role in dorsal root ganglia. Altogether my work highlights the role …
-
Generation and Analysis of Gene-Targeted Mouse Models for Oppenheim's Early-Onset Dyt1 Dystonia
… also detected in KI mice. Further motor learning behavioral testing revealed a severe deficiency of motor skill adaptation in KI mice that may be correlated with the absence of LTD. KD mice that expressed close to 60% of normal torsinA level showed that a reduced level of torsinA even in the …
-
Consequences of avian parental incubation behavior for within-clutch variance in incubation temperature and offspring behavioral phenotypes
… (i.e., >1C) to lead to different offspring phenotypes within broods (Chapter 2). Then, in a series of experiments in which I controlled incubation temperature, I provided evidence that lower average incubation temperatures lead to a reduced ability of ducklings to exit the nest cavity …
-
Epigenetic Mechanisms in Blast-Induced Neurotrauma
… with reduced astrocyte activation and an altered behavioral phenotype, which was characterized by high response to novelty. The diagnostic efficacy of epigenetic changes following blast was elucidated by the accumulation of cell-free nucleic acids in cerebrospinal fluid one month after injury. …
-
GENETIC DISSECTION OF AVERSION TO ALLYL ISOTHIOCYANATE IN Drosophila melanogaster
… (TRP) Channels, leading to many animal's behavioral aversion to the chemicals the plants produce. The TRPA subfamily, which in mammals has one member (TRPA1) responds to many electrophiles, including allyl isothiocyanate (AITC). Drosophila have four homologs to the mammalian TRPA1: dTRPA1, …
-
Understanding Autism Pathology: Insights from Genetic Mouse Model Manipulation of KCTD13 and SHANK3
… displays increased locomotor activity, a robust behavioral phenotype in 16p11.2 deletion mouse models. These results suggest that KCTD13 regulates neuronal morphology and synapse number and likely does so via alteration of RhoA signaling pathways. Together, these data implicate Kctd13 in …
-
Molecular Approaches to the Genetics of Obesity: Mapping and Characterization of the Murine Diabetes (db) Gene
… chromosome 4 which demonstrates a metabolic/behavioral phenotype similar to that observed in human obesity and Type II diabetes. Homozygous db animals manifest profound obesity with hyperphagia, increased metabolic efficiency, and insulin resistance. In an effort to clone this gene (and the …
-
Behavioral type - environment correlations in three-spined stickleback
… how non-random associations between the behavioral phenotype of individuals and the environment in which they occurred in the wild, hereafter referred to as behavioral type-environment correlations, affected important evolutionary and ecological processes in the three-spined stickleback …
-
Monoaminergic Regulation of MeCP2 Phosphorylation in Mouse Models of Psychiatric Disease
… protein 2 (MeCP2) contributes to both neural and behavioral adaptations induced by repeated psychostimulant exposure (Deng et al, 2010, Im et al, 2010). Psychostimulants induce rapid and robust phosphorylation of MeCP2 at Ser421 (pMeCP2), a site that is thought to modulate MeCP2-dependent …
-
Characterization of memories and ignorant (S6KII) mutants in operant conditioning in the heat-box
… have been generated. In precise jumpouts the phenotype was reverted. Imprecise jumpouts with a partial loss of the coding region were defective in operant conditioning. Surprisingly, null mutants showed wild-type behavior. This might indicate an indirect effect of the mutated ignorant gene on …
-
Molecular and Functional Characterization of Pyramidal Cell Types in the Frontal Cortex of Mouse Brain
… for Ntf3 cell type in the neocortex and studied behavioral phenotype of mice harboring cortex specific deletion of Wfs1. The Wfs1 Cortex KO mice were anhedonic and were impaired in their preference for sucrose, which is normally considered more pleasurable than water. The KO mice also exhibited …
Page 1 of 2