Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"behavioral impairments"”.
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The impact of supplemental vitamin D on motor learning and seizures in mice with hyperactive mTOR induced epilepsy and ataxia.
… disrupted cerebellar growth, debilitating motor impairments, and may contribute to the development of epilepsy. mTOR inhibitors can reduce seizures and may prevent behavioral impairments but are associated with serious side effects. Thus, a critical need for better therapies to treat individuals …
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Expectations and Stress Related to Choosing and Providing Treatment: A Comparative Study of Parents of Children with Autism Spectrum Disorders or with Down Syndrome
… predictor of parent stress, with social and behavioral impairments being especially salient. Children (mean age = 8.6) were currently enrolled in an average of 5.4 treatments and parents had tried nearly 10 interventions. The total number of treatments tried did not relate to measures of …
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Examination of the effect of a diet high in vitamin D in a preclinical model of fragile X syndrome.
… ribonucleoprotein (FMRP), leading to pronounced behavioral and cognitive impairments such as deficits in communication, repetitive behaviors, and intellectual disabilities. Additionally, individuals with FXS exhibit molecular abnormalities, including dysregulation of the mammalian target of …
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Targeting troubled translation : investigating novel therapeutic targets in mouse models of fragile X and 16p1 1.2 deletion syndrome
… corrected many biochemical, cognitive and behavioral impairments in 16p1 1 .2 df/+ mice supporting the hypothesis that troubled translation downstream of mGlu₅ may be a convergent point of dysfunction between these two genetically-defined disorders.
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Modeling subconcussive and cumulative subconcussive impacts using a lateral fluid percusion injury device
… factor for developing long-term cognitive and behavioral impairments. Curiously, cumulative head injuries sustained over an individuals’ career, involving contact activities (e.g. athletes and military personnel), are beginning to be implicated in long-term consequences, such as dementia. …
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Acute Metabolic and Neuroendocrine Responses to Maximal Treadmill Exercise in Patients Recovering from Traumatic Brain Injury (TBI)
… are subtle and may not be visibly evident. Impairments caused by TBI can lead to increased morbidity, decreased functional independence, and an increased reliance on the public health-care system. TBI can cause cognitive and behavioral impairments, reduced peak physical and metabolic work …
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The Effects of Treadmill Exercise in the P301S Mouse Model of Tau Pathology
… neurodegenerative tau pathology and associated behavioral impairments in the P301S-tau transgenic mouse model of tauopathy. Old (7-month old) and young (3-month old) P301S mice were subjected to 12- and 24-weeks of exercise, respectively. Following exercise, mice were given behavioral …
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ACQUIRED ALTERATIONS IN THALAMIC T-TYPE CALCIUM CHANNELS IN MODELS OF NEURONAL HYPEREXCITABILITY
… in thalamic T-type Ca2+ channels corresponded to behavioral correlates in both models. In the mouse model of acquired epilepsy, a reduced tendency for RE neurons to participate in T-type channel-mediated bursts was seen during the seizure-free period of epileptogenesis. In contrast, thalamic …
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The Differential Effects of Mental Fatigue and Alcohol on Selective Attention
Decrements in selective attention are a commonly experienced phenomenon that has practical implications for many industries. Two causes of such deficits are mental fatigue and alcohol intoxication, which impair selective attention by decreasing the efficiency of inhibitory processes. The present …
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ROLE OF STRESS EARLY IN LIFE AND OF INFLAMMATION IN THE RISK TO DEVELOP DEPRESSION LATER IN LIFE
… Using a multi-level approach that integrates behavioral, molecular, immunological, and transcriptomic analyses, I investigated the long-term effects of early stress exposure in a well-established PNS model routinely used in my laboratory (Creutzberg et al., 2023; Marchisella et al., 2021). My …