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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"basigin"”.
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The Overexpression of Basigin-3 in Glioblastoma
… to target and eradicate the disease. The protein Basigin-2 (aka EMMPRIN) induces the expression of matrix metalloproteinase (MMP) enzymes, and its expression level is positively correlated with GBM tumor grade. In 2011, Liao et al. reported that a splice variant of the basigin gene, called …
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Expression and Function of Basigin During Implantation in the Mouse
Taken together, our data suggested that basigin plays multiple roles during implantation by regulating uterine stromal cell differentiation, stimulating MMP production and inducing the expression of pro-inflammatory genes.
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Expression and function of basigin during early pregnancy and spermatogenesis
Basigin (BSG) is a multifunctional glycoprotein that plays an important role in both female and male reproduction since female knockout (KO) mice are infertile and male KO mice are sterile. The aim of the present study was to determine 1) whether BSG is required for proliferation of the uterine …
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Loss of basigin expression in the uterus reduces fertility in female mice
Basigin (BSG), a member of the immunoglobulin superfamily, is a transmembrane glycoprotein expressed in many cell types. It is involved in neurological processes, lymphocyte migration, angiogenesis, tissue remodeling and lactate transport. Our data show that Bsg is expressed in the reproductive …
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BASIGIN-2 MEDIATED ACTIVATION OF ERK1/2 SIGNALING IN HUMAN GLIOBLASTOMA MULTIFORME CELLS
… cancer. GBM tumor cells overexpress the protein Basigin (Bsg) at the cell surface where it contributes to malignancy via stimulation of matrix metalloproteinase (MMP) expression in surrounding normal tissues, resulting in the degradation of the extracellular matrix (ECM) surrounding tumors, …
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Role of the immunoglobulin superfamily member Basigin in sensory neuron dendrite morphogenesis in Drosophila
… In this thesis, I present data showing that Basigin, an immunoglobulin superfamily member, has somatodendritic and axonal localization in sensory neurons, and is enriched at cell borders and beneath class IV dendrites in epithelial cells. Loss of function analyses indicate that Basigin is …
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Purification and Characterization of an Anti-Basigin Monoclonal Antibody: Application to the Study of Human Uterine Cells and Tissues
… et al., 2013). The cell surface glycoprotein basigin-2 is necessary for embryo implantation in the mouse and plays a role in several cellular functions, including cell communication and extracellular matrix remodeling (Chen et al., 2009; K. Li & Nowak, 2020). <em>In vitro</em> studies using …
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The Possible Role for Basigin Receptor Function in The Induction of Matrix Metalloproteinase Expression in Human Endometrial Stromal Cells
… uterus is essential for successful implantation. Basigin has been shown to have vital functions within the implantation process. Basigin is best known for inducing the expression of matrix metalloproteinases. Basigin has been shown to induce MMP expression in vitro in human endometrial stromal …
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Expression and secretion of basigin by human placental trophoblast cells occurs via microvesicle shedding and is a regulated process
… tension. Previous studies have demonstrated that basigin (BSG)/extracellular matrix metalloproteinase inducer (EMMPRIN) is able to regulate MMP production and is critical for successful implantation, angiogenesis and parturition. However, expression and specific functions of BSG during the first …
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ANALYSIS OF TUMOR SPECIFIC PROTEIN EXPRESSION IN GLIOBLASTOMA MULTIFORME (GBMs) TUMORS THROUGH IMMUNOHISTOCHEMISTRY
… tumors have a higher expression of the protein Basigin and O6-methylguanine-DNA-methyltrasnferase (MGMT) present, causing it to be more aggressive and less responsive to standard care. The objective of this study was to understand the correlation between IDH1 mutation presence and the expression …
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Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism
… of TMPRSS11B promotes membrane release of Basigin, an obligate chaperone of the lactate monocarboxylate transporters MCT1 and MCT4. To investigate whether TMPRSS11B regulates lactate transport, we monitored intracellular lactate content and lactate secretion. Our data suggest TMPRSS11B …
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Molekulare Mechanismen und Asymmetrie im Transport von Lactat
… transportmodulierende Effekt des MCT-Chaperons Basigin untersucht. Basierend auf Molecular Dynamics-Simulationen und experimentellen 14C-Transportuntersuchungen wurde folgender regulatorischer Mechanismus postuliert: Die extrazelluläre Ig-I-Domäne des Basigins kann den MCT-Transportpfad …
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Synaptic physiology of the developing <i>Drosophila</i> neuromuscular junction
… wird das neue perisynaptische Protein Basigin vorgestellt. Basigin trägt zu der Integrität des präsynaptischen Aktinzytoskeletts und der Präzision synchronisierter Freisetzung von Neurotransmittern bei. Die Ergebnisse der Untersuchung veranschaulichen die Beteiligung dieser Proteine an …
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CD147 AS A POTENTIAL THERAPEUTIC TARGET IN GLIOBLASTOMA TREATMENT
… human surface glycoprotein CD147, also known as basigin, is expressed at significantly higher levels in GBMs compared to non-neoplastic brain tissue. Furthermore, levels of CD147 expression correlate with brain tumor progression and show the highest expression in GBM. Here, we suppressed tumor …
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CHARACTERIZATION OF THERANOSTIC PEPTIDES FOR GLIOBLASTOMA MULTIFORME
… <em>in</em>ducer (EMMPRIN; Basigin) isoform 2, toward U87 GBM and MSU 1.1 human foreskin fibroblast cell line labelling. A novel cDNA construct coding a recombinant chlorotoxin (rCTX) variant for periplasmic prokaryotic expression and histidine-tag purification was created. …
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Discovery of prognostic biomarkers from the prostate cancer membrane proteome using bioorthogonal chemistry
… of the prostate cancer cell lines revealed that Basigin (CD147) glycosylation, which showed a strong increase in Ac4ManNAz and Ac4GalNAz labelling, correlated with an increase in metastatic potential, despite its total expression decreasing across the panel of prostate cancer cell lines. In …