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Showing 1 to 20 of 73 for “"basic helix loop helix"”.
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Structural studies on the basic-helix-loop-helix region from MyoD
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1994.
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Molecular Interactions of Basic Helix Loop Helix (bHLH) Genes in Inner Ear Development
… embryogenesis. Major players in these events are basic helix-loop-helix (bHLH) genes: Neurogl, Atohl and Neurodl. We investigated whether co-expression of Neurogl and Atohl in common neurosensory precursors could explain the loss of hair cells in Neurogl null mice. Analysis of terminal mitosis, …
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Investigating the role of the basic helix-loop-helix transcription factor MIST1 in pancreatic diseases
<p>Acinar cells of the exocrine pancreas are dedicated to synthesize, package and secrete immense quantities of pro-digestive enzymes to maintain proper metabolic homeostasis for the organism. Dysregulation of enzyme secretion in acinar cells can give rise to exocrine diseases including acute …
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Control of Neuroendocrine Cell Physiology by a Single Transcription Factor, Drosophila Basic Helix Loop Helix Regulator DIMMED
… secretory pathway. In this context, the basic helix-loop-helix transcription factor dimmed: dimm) is especially important in the fruit fly Drosophila, but it is not involved in neuroendocrine cell fate determination.</p> <p>Neuroendocrine cells require DIMM to accumulate, and process …
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Part I characterization of MyoR in C2C12 mouse fibroblasts. Part II isolation and characterization of a novel class II bHLH transcription factor from the black widow spider, latrodectus hesperus
<p>PART I</p> <p>The basic helix-loop-helix (bHLH) family of transcription factors are involved in a variety of developmental processes. MyoR is the mouse homologue of the human transcription factor ABF-1 . MyoR is classified as a class II basic-helix-loop-helix transcription factor. In order to …
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Construction of an ABF-1 inducible expression cell line utilized to conduct a microarray analysis
<p>ABF-1 is a human class ll basic helix-loop-helix transcription factor that is expressed predominately in EBV immortalized and activated B lymphocytes. A human cell line was stably transfected with a tetracycline regulated ABF-1 expression vector. The cell line revealed tight regulation of ABF-1 …
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Isolation of novel ABF-1 splice forms
… represents the only member belonging to the basic helix-loop-helix (bHLH) family of transcription factors whose expression pattern is restricted to B cells. ABF-1 forms heterodirner complexes with E2A to modulate gene transcription. Here we report the isolation often novel ABF-1 splice …
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Development of a human plasmacytoma cell line with inducible expression of activated B-cell factor-1
<p>The basic helix-loop-helix protein, activated B-cell factor-l (ABF-l), is a transcription factor involved in cellular proliferation and differentiation. ABF-1 shows patterns of expression that are stimulated in activated B cells, which may suggest ABF-1 is involved in the regulation of B-cell …
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Analysis of the role of extracellular signal regulated kinase (ERK5) in the differentiation of muscle cells
… containing promoter element, where myogenic basic-helix-loop-helix proteins such as MyoD or myogenin bind. Moreover, myogenic differentiation is completely blocked, when ERK5 expression is inhibited by antisense RNA. The effect can be detected also on the expression level of myogenic …
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Development of a Burkitt Lymphoma cell line with inducible expression of activated B-cell factor-1
… B-cell Factor-I (ABF-1) is a class II basic helix-loop-helix protein expressed in activated B-cells, EBV -immortalized lymphoblastoid cell lines and embryonic skeletal muscle in mice. ABF -1 dimerizes with another bHLH protein E4 7 to form a transcriptional repressor ofE2A, which is a …
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Control of Cardiac and Limb Development by the bHLH Transcription Factors DHAND and eHAND
Members of the basic helix-loop-helix (bHLH) transcription factor family regulate the specification and differentiation of multiple cell lineages during embryonic development. The bHLH proteins dHAND and eHAND are expressed in complimentary and overlapping patterns during embryogenesis, and gene …
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Evidence that ARNT plays a role in the regulation of the immunoglobulin heavy chain enhancer and identification of a putative ARNT ligand
<p>Basic helix-loop-helix (bHLH) proteins are involved in the regulation of a multitude of developmental processes including cellular differentiation, cellular proliferation and xenobiotic metabolism. Among the members of the bHLH protein family are the products of the Pan gene Pan-1, Pan-2 and ITF …
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Characterization of downstream target genes regulated by ABF-1 in different states of B cell development
… gene encodes for a protein that belongs to the basic helix-loop-helix family of transcription factors. ABF-1 mRNA molecules have been detected in the lymphoid tissues, which include the bone marrow, lymph nodes, and appendix, as well as transformed B cells lines infected with Epstein-Barr virus. …
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Discovery and characterization of a small molecule that modulates c-Myc mediated transcription via max homodimer stabilization
The transcription factor Myc is a basic helix-loop-helix leucine zipper (bHLHLZ) protein with crucial roles in regulating normal cellular processes, but its transcriptional activity is deregulated in a majority of human cancers. Myc transcriptional activity is dependent on dimerization with its …
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Isolation and characterization of CEABF-1, the ABF-1 homolog in C. elegans
<p>The basic helix-loop-helix (bHbH) family-of transcription factors is important in many developmental and regulatory pathways such as cellular proliferation and differentiation, lineage commitment, sex determination, neurogenesis, myogenesis, hematopoeisis and pancreatic development. The …
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The Role of Mga in the Survival of Pluripotent Cells During Peri-implantation Development
… Mga contains both a T-box binding domain and a basic helix-loop-helix zipper (bHLHZip) domain. Loss of Mga leads to embryonic lethality by E5.5. In vitro blastocyst culture and embryonic stem (ES) cell culture identify a lack of pluripotent inner cell mass (ICM) derived cells as the cause of …
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Analysis of ASCL1 in Neuroendocrine Lung Cancer
… Previous studies have determined that the basic helix-loop-helix (bHLH) transcription factor achaete-scute homolog 1 (ASCL1) is essential for the survival and progression of many pulmonary neuroendocrine (NE) cancer cells, which include both SCLC and some non-small cell lung cancer (NSCLC). …
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Mapping of the repression domain and the subcellular localization of the ABF-1 protein
<p>Basic helix-loop-helix transcription factors play important roles in pathways that result in the formation of such tissues as skeletal muscle, the nervous system, pancreas and heart. A recently discovered B-cell restricted bHLH transcription factor activated Bcell factor 1 (ABF -1) is suspected …
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Roles of Neurogenin and Geminin in Vertebrate Neurogensis
… and geminin in vertebrate neurogenesis Proneural basic helix-loop-helix transcription factors regulate cell fate commitment and differentiation in neurogenesis. However, their proneural functions are not well understood, in part due to a lack of information about their target genes. Here, we …
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Intrinsic Specificity of Binding and Regulatory Function of Class II bHLH Transcription Factors
… genome. ASCL1, ASCL2, and MYOD are class II basic Helix-Loop-Helix (bHLH) transcription factors which play crucial roles in lineage specification in the developing embryo. In vivo, these factors bind to distinct genomic sites, and regulate distinct transcriptional programs. The mechanisms by …
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