Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"basic fibroblast growth factor (bFGF)"”.
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Purification and Characterization of Proteoglycan from Bovine Aortic Endothelial Cells Conditioned Media, and its Interaction with Basic Fibroblast Growth Factor (bFGF)
… sulfate proteoglycans (HSPG), which bound basic fibrobalst growth factor (bFGF). bFGF is a known mitogen for vascular smooth muscle cells, and is indicated to have a role in some proliferative vascular disorders. In the present study, we have purified proteoglycans from BAE cells …
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The Effects of Angiogenic Growth Factors on Mesenchymal Stem Cell Proliferation and Differentiation to Vascular Cell Fates
… In this study, we investigated the effects of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF), two of the best-characterized angiogenic factors, on MSC proliferation and differentiation. We hypothesized that treatment with these two factors could inhibit …
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Characterization of the Effects of bFGF and GSK3β Inhibitors on Embryoid Bodies Derived from Human Pluripotent Stem Cells
… Previous work suggests that EBs are sensitive to growth factor withdrawal if they are derived from hPSCs maintained in feeder independent media such as mTeSR1. To promote cell survival, EBs generated from mTeSR1-adapted hPSCs are sometimes cultured in a medium that contains basic fibroblast growth …
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Stimulation of angiogenesis through growth factor delivery from synthetic heparinised hydrogels
… and controlled release of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), as well as their bioactivity and angiogenic potential in vivo. Methodology: VEGF and bFGF were combined into 4% (m/v) PEG-Hep hydrogels. The binding and release rates of VEGF and BFGF …
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Synthetic Efforts Toward Hypoestoxide, Platensimycin, And Guttiferone G
… activity that inhibits vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) make it especially interesting. Along with this biological profile, the challenging macrocyclic structure of hypoestoxide makes it a target of great interest to the synthetic community. …
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Synthesis and Characterization of Novel Polyester Scaffolds from Sugarcane Industry By-products for Use in Skin and Bone Tissue Engineering
… mass loss in stromal medium, ability to support growth and proliferation of human adipose derived mesenchymal stem cells (hASC). Several biocompatibility tests such as mass loss over a period of time, alamar blue to analyze growth and viability of hASC on polyester scaffolds, picogreen for total …
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The role of basic fibroblast growth factor in the compensatory adrenal growth response
We have investigated the role of basic fibroblast growth factor (bFGF) in the neurally mediated compensatory adrenal growth response. Unilateral adrenalectomy resulted in a 13%, 6% and 22% increase in adrenal weight, protein and DNA content, respectively, and 33-40% increases in the rate of cell …
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Molecular and cellular regulation of motoneuron differentiation of human neural stem cells
… developed an in vitro procedure consisting of basic fibroblast growth factor (bFGF), heparin and laminin (FHL), which directs human fetal neural stem cells (hNSCs) to differentiate into choline acetyltransferase (ChAT) motoneurons in vitro and after transplantation into the rodent spinal cord …
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Humna fetal neural stem cells: Proliferation and differentiation in response to growth factors and role in locomotor recovery after spinal cord contusion injury
… were cultured in seven regimens with basic fibroblast growth factor (bFGF), epidermal growth factor (EGF) and leukemia inhibitory factor (LIF), either alone or in combinations. We found that a combination of bFGF, EGF and LIF expanded hNSCs more efficiently than any other treatment. …
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The Isolation and Characterization of Growth Regulatory Factors Produced by a Herpes Simplex Virus Type 2 Transformed Mouse Tumor Cell Line, H238
… to associate HSV-2-transformation with specific growth factors in order to develop a testable model for HSV-2-transformation. For some tumor viruses, particularly those containing RNA, there has been a central concept (autocrine secretion) linking oncogenes and growth factors. This concept …
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Role of basic fibroblast growth factor in the development of sensitization to the effects of amphetamine
… development. In this thesis, the hypothesis that basic fibroblast growth factor (bFGF), a neurotrophic factor produced by astrocytes, plays a crucial role in the development of sensitization was tested. A series of experiments was conducted to assess whether bFGF expression in cell body regions of …
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Effect of laminar shear stress on gene regulation, protein synthesis, and protein secretion by cultured human endothelial cells
… message RNA for endothelin. The mRNA level of basic fibroblast growth factor (bFGF) was found to be the same in cells sheared for 24 hours as in controls. Enhancement of the fibrinolytic potential of endothelial cells in response to hemodynamic forces involves transcriptional events and could …
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Steroid induced neuroprotection of damaged photoreceptor cells
… Norgestrel induces a increase in neuroprotective basic fibroblast growth factor (bFGF) with subsequent downstream actions on the inhibition of glycogen synthase kinase 3β. Progesterone receptor expression was subsequently characterised in the C57 and rd10 retinas and in the 661W cell line. …
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Modified polyethylene glycol hydrogels for growth factor delivery and controlled tissue invasion
… of potentially cardioprotective and regenerative growth factors from biomaterial scaffolds. One hydrogel system that has promise in this area is an injectable enzymatically degradable polyethylene glycol (PEG) hydrogel. Two modifications aimed at further optimising this system as a regenerative …
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Efficacy of Wearable Therapies on the Ability to Improve Performance and Physical Health in Sport Horses
… skin which can have detrimental effects on the fibroblasts which can lead to failure. It was not until the early twentieth century that the idea of equine physiotherapy was adopted, and practices changed to meet remedial needs and create a sustainable, healthy equine athlete. Equine …
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The prevention of heparanase expression in endothelial cells injured by high glucose
… (0.5 ìg/ml) and/or insulin (1 U/ml) and/or basic fibroblast growth factor (bFGF, 1 ng/ml) to determine if these compounds protected ECs from injury or inhibited heparanase expression induced by high glucose. p* PAECs injured by high glucose or heparinase I (0.3 U/ml in serum free medium) …
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Redox biology in retinal degeneration
… membrane component 1 (PGRMC1); the neurotrophic factor basic fibroblast growth factor (bFGF) and its ability to reduce inflammation and gliosis in the diseased retina. Reactive oxygen species (ROS), have been traditionally associated with cellular damage, and have been discovered to participate …
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Investigation on the Molecular Mechanism of Photorejuvenation in Photodynamic Therapy
… which is examined direct effect of PDT on fibroblast (FB), PDT induced increase of matrix metalloproteinase (MMP)-3 and collagen type Iα through prolonged activation of extracellular signal–regulated kinase (ERK). Increased MMP-3 may induce breakage of old collagen and allow new collagen …
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Protective effect of JAK3 inhibition on growth factor deprivation induced neural progenitor cell death
… when NECs are substantially proliferated by growth factors(GFs). The extrinsic factors such as epidermal growth factor (EGF), basic fibroblast growth factor(bFGF), as well as intrinsic protein regulate growth, proliferation and differentiation. Therefore, in culture system, addition of both …
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Therapeutic Effects of Human Mesenchymal Stem Cells on Traumatic Brain Injury in Rats: Secretion of Neurotrophic Factors and Inhibition of Apoptosis
… the secondary mechanism of TBI depends upon two factors: injury severity (mild, moderate or severe) and location of the primary injury. Secondary brain damage has been known to involve neuroinflammatory, apoptotic and oxidative stress mechanisms which are mainly dependent on intracerebral …
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