Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"basic fibroblast growth factor"”.
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Heparan sulfate mediated transport of basic fibroblast growth factor through extracellular matrix
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1998.
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Nuclear Basic Fibroblast Growth Factor Regulation of Triple-Negative Breast Cancer Dormancy/Recurrence
… three years of treatment due to recurrent tumor growth. Developing ex vivo models for TN breast cancer recurrence and defining responsible molecules will be crucial to developing effective combination therapies for TN breast cancer patients. We have developed an in vitro model of TN breast cancer …
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The role of basic fibroblast growth factor in the compensatory adrenal growth response
We have investigated the role of basic fibroblast growth factor (bFGF) in the neurally mediated compensatory adrenal growth response. Unilateral adrenalectomy resulted in a 13%, 6% and 22% increase in adrenal weight, protein and DNA content, respectively, and 33-40% increases in the rate of cell …
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Effects of bFGF (Basic Fibroblast growth factor) on the Haematopoietic Sequelae that follow transplantation
… also affected, resulting in poor support for the growth of stroma-adherent multipotent progenitors that form blastic colonies (CFU-bl). To determine the possible mechanisms of marrow damage in patients treated with peripheral blood stem cells (PBSCs) and bone marrow transplantation (BMT), we …
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Role of basic fibroblast growth factor in the development of sensitization to the effects of amphetamine
… development. In this thesis, the hypothesis that basic fibroblast growth factor (bFGF), a neurotrophic factor produced by astrocytes, plays a crucial role in the development of sensitization was tested. A series of experiments was conducted to assess whether bFGF expression in cell body regions of …
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Purification and Characterization of Proteoglycan from Bovine Aortic Endothelial Cells Conditioned Media, and its Interaction with Basic Fibroblast Growth Factor (bFGF)
… sulfate proteoglycans (HSPG), which bound basic fibrobalst growth factor (bFGF). bFGF is a known mitogen for vascular smooth muscle cells, and is indicated to have a role in some proliferative vascular disorders. In the present study, we have purified proteoglycans from BAE cells …
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The Effects of Angiogenic Growth Factors on Mesenchymal Stem Cell Proliferation and Differentiation to Vascular Cell Fates
… In this study, we investigated the effects of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF), two of the best-characterized angiogenic factors, on MSC proliferation and differentiation. We hypothesized that treatment with these two factors could inhibit …
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Glycosaminoglycan-protein interactions : the fibroblast growth factor paradigm
… such as anticoagulation, angiogenesis and growth factor activation. The specificity involved in the HSGAG-protein interactions stems from the structural heterogeneity of HSGAGs, which are highly acidic biopolymers associated on the cell surface and in the extracellular matrix. It is …
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Directed differentiation of endodermal cells from mouse embryonic stem cells
… and liver. By using all-trans-retinoic acid, basic fibroblast growth factor, dibutyryl cAMP, and cyclopamine, an attempt has been made to produce definitive endoderm and subsequently cells that can serve as pancreatic and hepatocyte precursors from mouse embryonic stem cells. By using retinoic …
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Escherichia Coli as a New Platform for the Study of Phosphoinositides
… trough the addition of inositol to the growth media of the bacterium. As an example application of my system, I use it to confirm the role of PIP2 binding in the non-conventional protein export of human basic fibroblast growth factor (FGF2).</p>
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Characterization of the Effects of bFGF and GSK3β Inhibitors on Embryoid Bodies Derived from Human Pluripotent Stem Cells
… Previous work suggests that EBs are sensitive to growth factor withdrawal if they are derived from hPSCs maintained in feeder independent media such as mTeSR1. To promote cell survival, EBs generated from mTeSR1-adapted hPSCs are sometimes cultured in a medium that contains basic fibroblast growth …
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Stimulation of angiogenesis through growth factor delivery from synthetic heparinised hydrogels
… and controlled release of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), as well as their bioactivity and angiogenic potential in vivo. Methodology: VEGF and bFGF were combined into 4% (m/v) PEG-Hep hydrogels. The binding and release rates of VEGF and BFGF …
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Synthetic Efforts Toward Hypoestoxide, Platensimycin, And Guttiferone G
… activity that inhibits vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) make it especially interesting. Along with this biological profile, the challenging macrocyclic structure of hypoestoxide makes it a target of great interest to the synthetic community. …
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