Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 127 for “"basement membrane"”.
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Nephrotic Syndrome and Glomerular Basement Membrane: Genetic Defect of the Laminin α5 Chain
… γ1, it is a major component of the glomerular basement membrane. Mutations in <i>LAMB2</i> are associated with Pierson’s syndrome and mutations in <i>LAMA5</i> have recently been identified in paediatric patients affected by nephrotic syndrome. <br></br><br></br> As part of the MRC Harwell …
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Gene expression studies of pregastrulation development: the basement membrane is essential for cell differentiation
Basement membranes (BMs) are sheet-like structures of extracellular matrix. They act as a supporting structure but can also significantly influence cellular behavior in development, tissue homeostasis and disease. Laminins, a major BM component, are multidomain proteins, consisting of three …
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Notch Regulates Vascular Collagen IV Basement Membrane Through Modulation of Lysyl Hydroxylase 3 Trafficking
<p>Collagen type IV (Col IV) is a basement membrane protein associated with early blood vessel morphogenesis and is essential for blood vessel stability. Defects in vascular Col IV deposition are the basis of heritable disorders, such as small vessel disease, marked by cerebral hemorrhage and …
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Identifying novel roles for basement membrane-associated proteins in the adult Drosophila intestinal epithelium
… A potential source of such signals is the basement membrane, a thin extracellular matrix which underlines the basal side of all epithelia, and to which epithelial cells adhere via various receptors. Despite their ubiquity, basement membranes are understudied and there remains much to …
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Permeation of ficoll and ficoll sulfate through glomeruler basement membrane : effects of molecular size and charge
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1998.
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Endothelial cells and basement membrane : a co-regulatory unit for fibroblast growth factor-2 in hyperglycemic stress
Endothelial cells and basement membrane interact as a biochemical and mechanical co-regulatory unit. The wide spectrum of manifestations of diabetic vascular disease could be related to altered kinetics of vasoactive compounds within this regulatory unit. We hypothesized that hyperglycemic stress …
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A Glomerular Basement Membrane-on-a-Chip Model for Investigating Charge-Selective Transport Across the Human Filtration Barrier
… the body. However, during dialysis, blood–membrane interactions activate the coagulation cascade and complement system, leading to protein adsorption on the membrane surface, impaired filtration, and adverse patient outcomes. This underscores the need for biocompatible membranes that better …
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Targeted Overexpression Of Metallothionein In Endothelial Cells Mitigates Pulmonary Alveolar Basement Membrane Thickening In Transgenic Diabetic Ove Mice: An Unbiased Tem Morphometric Analysis
… This is manifested morphologically by capillary basement membrane (BM) thickening, the hallmark feature of chronic complications of DM. In an effort to demonstrate pulmonary alveolar BM (PABM) thickness increase in DM and to demonstrate for the first time, mitigation of the increase utilizing …
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Evaluation of cerebrospinal fluid biomarkers of endothelial damage and basement membrane degradation as indirect indicators of blood-brain barrier dysfunction in chronic canine hypothyroidism
A variety of neurologic illnesses including peripheral and cranial neuropathies, central vestibular disease, seizures and coma have been associated with hypothyroidism in dogs. Repeated studies have shown that there is loss of blood brain barrier (BBB) integrity in these animals. Current research …
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Morphogenesis of the early post-implantation mouse embryo
… participates in formation of the extraembryonic membranes. The major aims of my PhD studies have been to reveal how this cavity is formed (Aim 1) and then how the egg cylinder grows (Aim 2). In order to address how the pro-amniotic cavity forms (Aim 1), I first characterised in detail development …
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AMNIOTIC MEMBRANE TRANSPLANTATION FOR OCULAR SURFACE RECONSTRUCTION IN VETERINARY MEDICINE
The fetal membrane is composed by the chorion, allantois and amnion. The AM is the inner layer. It consists of a single layer of ectodermally derived cuboidal to columnar cells, which form the epithelium, a basement membrane that connects with the chorion by a layer of mesenchyme which contains …
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Factors affecting severity of injury in allergic renal disease
… containing antibodies to rabbit glomerular basement membrane. In a second group of experiments, the induction of an acute phase response in rabbits by the subcutaneous injection of a local irritant was studied. It was characterised by changes in C-reactive protein (CRP), the third component …
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The Role of Perivascular Fibrosis In Post-Stroke Glymphatic Impairment and Cerebral Amyloid Angiopathy
… matrix deposition within the vascular basement membrane, termed fibrosis, impairs Aβ drainage from the aged brain after stroke. I further hypothesize that inhibition of astrocytic transforming growth factor-β (TGF-β) signaling can reverse these phenotypes. Finally, I also hypothesize …
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Integrin signalling in pluripotent cells acts as a gatekeeper of mouse germline entry
… signalling interactions with the underlying basement membrane and specify in a region that is physically segregated from it. In line with this, the addition of an exogenous extracellular matrix (ECM) inhibits PGC specification in *in vitro*-cultured mouse embryos, as well as during PGC-like …
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Molecular determinants of mammary differentiation and breast cancer progression
… that SMARCE1 cooperates with ILF3 to regulate a basement membrane module and that it is functionally required to degrade basement membrane. Afterwards, I describe CREB3L1 as a key mediator of PERK-driven metastasis. We also showed that the unique mode of action of CREB3L1 provides a therapeutic …
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Analysis of a Proposed Cell Binding Site on Caenorhabditis Elegans Collagen Type Iv
Collagen IV (col IV), a basement membrane protein, provides structural support and regulation of cell migration and binding. C. elegans body wall muscle col IV consists of two alpha 1 chains and one alpha 2 chain. The human col IV molecule has a cell binding site (CBS) composed of aspartate (D) on …
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