Global ETD Search

DNA mit Thiobasen und polycyclischen aromatischen Basensurrogaten zur Untersuchung des Base Flipping am Beispiel der DNA-Methyltransferase M.TaqI

Beuck, ChristineMainz2005

aachen Repository record for DNA mit Thiobasen und polycyclischen aromatischen Basensurrogaten zur Untersuchung des Base Flipping am Beispiel der DNA-Methyltransferase M.TaqI (opens in a new tab)

A directed evolution design of target specificity and kinetic analysis of conformational transitions in the HhaI methyltransferase /

Gerasimaitė, Rūta,Institutional Repository of Vilnius University2011

… A new method to follow the target cytosine flipping and its subsequent covalent activation has been proposed, which allows a direct real-time observation of these processes by monitoring associated UV absorbance changes in a chemically unperturbed DNA. These studies for the first time …

vilnius Repository record for A directed evolution design of target specificity and kinetic analysis of conformational transitions in the HhaI methyltransferase / (opens in a new tab)

Berechnung des Circulardichroismus von beta-Oligopeptiden und Oligonucleotiden mit dem klassischen 'Dipole Interaction Model' und der quantenmechanischen Matrixmethode

Repges, RudolfPublikationsserver der RWTH Aachen University2006

… with the experiment. In the examination of the base-flipping mechanism of the DNA, in which Beuck and Weinhold have replaced a base with the appropriate thiobase at different positions of the DNA (Beuck, Promotion 2004, RWTH-Aachen), the theoretical spectra show qualitatively the same change …

aachen Repository record for Berechnung des Circulardichroismus von beta-Oligopeptiden und Oligonucleotiden mit dem klassischen 'Dipole Interaction Model' und der quantenmechanischen Matrixmethode (opens in a new tab)

Strukturanalyse der Methyltransferasen AviRa und AviRb aus S. viridochromogenes

Mosbacher, Tanja

… (AdoMet) auf jeweils eine spezifische Base im Peptidyltransferase-loop der 23S-rRNA und verhindern so die Bindung des endogenen Antibiotikums Avilamycin in diesem Bereich. <br>Beide Enzyme wurden in E. coli exprimiert. Zur Reinigung von AviRa diente eine Anionenaustauschchromatographie. …

freiburg-diss Repository record for Strukturanalyse der Methyltransferasen AviRa und AviRb aus S. viridochromogenes (opens in a new tab)

Y-family DNA polymerase architecture: three structural features control accurate deoxy CTP insertion opposite N2-deoxy-guanine-benzo-a-pyrene

Sholder, Gabriel D.2014

… cavity in the major groove side, which may allow base flipping and dGTP insertion opposite -BP, while k/IV/Dbh-type polymerases do not. When this cavity is plugged in Dpo4 by mutagenesis or the introduction of an N-clasp motif, dGTP rates increase by nearly 20-fold. In conclusion, this data …

bu Repository record for Y-family DNA polymerase architecture: three structural features control accurate deoxy CTP insertion opposite N2-deoxy-guanine-benzo-a-pyrene (opens in a new tab)

Relating structure and function: Discovery of novel inhibitors of myotonic dystrophy

Hagler, Lauren DUniversity of Illinois at Urbana-Champaign2020

… understand the conformational dynamics of uracil base flipping and how small molecules might interact in this binding mode but also to the development of new ligands through structure-based drug design. The design of base binding ligands was validated by X-ray crystallography. These principles are …

uiuc Repository record for Relating structure and function: Discovery of novel inhibitors of myotonic dystrophy (opens in a new tab)