Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"basal synaptic transmission"”.
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Role of the different domains of PSD-95 in basal synaptic transmission
… mit Veränderungen in der Stärke der synaptischen Transmission. An exzitatorischen Synapsen in der CA1-Region des Hippocampus wird die synaptische Transmission imWesentlichen durch in der postsynaptische Verdichtung befindliche AMPA-Rezeptoren reguliert. Deren Funktion wird durch PSD-95 reguliert, …
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Functional Characterization of Hippocampal Synapses in a Mouse Mutant of the Dystrobrevin Binding Protein 1 (DTNBP 1) Gene
… that dysbindin deficiency leads to defects in synaptic transmission. However, the specific impairments reported have been variable and inconsistent even at the same synapse. I conducted an independent functional characterization of hippocampal synapses in sandy mice, which contain a spontaneous …
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Studies on the effect of growth hormone on age-related changes in glutamatergic transmission in the hippocampus
… and these receptors are important for the basal synaptic transmission and long term potentiation (LTP) that underlie learning and memory processes. Cognitive function has been reported to decline with age, as reflected by a decline in performance on hippocampal-dependent tests of learning …
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Genetic analysis of synaptogyrin function in the synaptic vesicle cycle
… relies on the continual replenishment of synaptic vesicles that are primed for neurotransmitter release in response to action potentials. A vast array of proteins is required to mediate synaptic vesicle biogenesis, trafficking, docking, exocytosis, and endocytosis. Synaptogyrin and …
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Gene therapy for epilepsy: resculpturing synaptic transmission with neuropeptides
… in the hippocampus by suppressing glutamatergic transmission. If manipulated, the NPY system may be capable of restoring the imbalance between excitation and inhibition occurring in the epileptic brain. Indeed, emerging evidence has established a proof-of-principle for viral vector-mediated …
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Rapid neuronal responses during spreading neurotoxic and neuroprotective network activity
… nervous system, playing critical roles in basal synaptic transmission and the molecular correlates of learning and memory, long-term potentiation and long-term depression. However, glutamate is also neurotoxic during prolonged exposure and the dysfunction of the glutamatergic system has …
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Characterisation of transgenic mouse models of Alzheimer's disease
… 3xTg mouse does, however, present a deficit in basal synaptic transmission which is progressive with increasing age from 6-17 months. Similarly, hippocampal synaptic function is normal in TASTPM mice studied at 2 months, when no biochemical changes are present, but is markedly reduced at the age …