Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 87 for “"basal levels"”.
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CHRONIC STRESS REVEALS COGNITIVE IMPAIRMENT IN A SUBTHRESHOLD AMYLOID-BETA MODEL OF ALZHEIMER’S DISEASE
… that animals subjected to stress have reduced basal levels of p-CaMKII, decreased p-CaMKII/CaMKII ratio, and increased basal levels of calcineurin. The infusion of subAβ into the cerebral ventricle of chronically stressed rats also decreased basal levels of p-CREB, total CREB and BDNF and …
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Identification of the Pla2 Responsible For Prostanoid Synthesis in Response to Inflammatory Cytokines
… (e.g. IL-1β or TNFα), as well as regulating the basal levels of this prostanoid. Furthermore, cPLA2γ, cPLA2δ, and iPLA2 were found to also to regulate the basal levels of PGE2 production. On the other hand, cPLA2β was not involved in prostanoid synthesis in A549 cells either in the presence or …
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THE PROTECTIVE EFFECTS OF CHRONIC CAFFEINE TREATMENT ON THE COGNITIVE FUNCTION AND SYNAPTIC PLASTICITY IN ACUTE SLEEP DEPRIVATION
… and western blot analysis to measure the levels of memory- and synaptic plasticity-related signaling molecules. Results: Our results showed that chronic caffeine treatment prevented impairment of hippocampus-dependent learning, short-term memory and early phase- long-term potentiation …
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Characterization of Murine Cytomegalovirus m142 and m143 Essential Gene Products
… m143 transcripts were present during IE times, levels of these two transcripts increased during early times of viral infection and remained abundant during late times. The genes, m142 and m143, encode a 1.8 and 3.8 kb transcript, respectively. The m142 and m143 proteins (designated pm142 and …
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Characterization of metallothionein expression in response to cadmium in the 267-B1, normal prostate cell line
… and 4, 8, 12, 16, 24, 36, and 48hr recovery. Basal levels of mRNA for MT-1E, MT-1X, and MT-2A genes in 267-B1 cells were similar to the expression of the G3PDH where as MT-3 had a low basal level expression. Exposure to Cd2+ following recovery in normal medium showed the expression of MT-1A, …
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Ecological energetics of Eudyptes penguins at Marion Island
… over 24 h, averaged 25 % greater than basal metabolic rates predicted from allometric equations. Body temperatures of the penguins and the relationships between metabolic rates and temperature were investigated over a range of -10°C to 25°C. Lower critical temperature of Rockhopper …
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Role of BEC-1/Beclin 1 and Autophagy Genes in <i>C.elegans</i> Germline Cell Proliferation
… in the cellular adaptation to stress and basal levels of autophagy are crucial for cellular metabolism and homeostasis. Cellular recycling by autophagy is characterized by the formation of distinctive double-membrane vesicles (autophagosomes) that engulf unnecessary cytoplasmic components, …
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Dissecting the Spatiotemporal Regulation of Yeast Kinetochore Interactions
… cell cycle. Cnn1 localizes to kinetochores at basal levels from G1 through metaphase but accumulates abruptly at anaphase onset. How Cnn1 is recruited and which activities regulate its dynamic localization is unclear. We show that Cnn1 harbors two kinetochore-localization activities: a …
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Mechanisms of Calcium Buffering and Aging in Neurons: Testing the Limits of Homeostasis
… reacts quickly to restore [Ca<sup>2+</sup>]i to basal levels in order to reset the cell for the next stimulus and avoid prolonged exposure to cytotoxic levels of high [Ca<sup>2+</sup>]i. The aging process appears to causes multiple changes in the ability of neurons to regulate [Ca<sup>2+</sup>]i …
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Effects of Estradiol on Leydig Cell Function and Testicular Development in the Prepubertal Bull
… chorionic gonadotropin (hCG). Serum hormone levels were determined weekly. At 39 weeks of age, E and P calves were castrated for histologic evaluation of the testes and assessment of in vitro Leydig cell function. Serum E$\sb2$ was greater than 100 pg/ml in all calves at birth but decreased …
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Stress response genes in the human proximal tubules
… hsp 27, hsp 60 and hsp 70 mRNA and protein. The basal levels of expression of hsp 27 and hsp 60 in the HK-2 cells were elevated compared to unstressed HPT cells. These results suggest that failure of HK-2 cells to increase hsp 27 and hsp 60 levels in response to stress is because of their …
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Insulin-mediated inhibition of tyrosinase activity and protein synthesis in melanoma cell cultures
Insulin lowers basal levels of tyrosinase activity and inhibits the MSH-stimulated rise in tyrosinase in Cloudman S-91 mouse melanoma cell cultures. These cultures are very sensitive to insulin. A concentration of insulin as low as 5 x 10 M insulin produces optimum inhibition. At maximum …
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Antioxidant Programs Are Essential for Enzalutamide-Resistant Prostate Cancer
… PCa (CRPC) tumors had dramatically higher levels of both basal and inducible levels of reactive oxygen species (ROS) than either enzalutamide-sensitive PCa cells or primary therapy-naïve tumors, respectively. Unbiased metabolomic evaluation identified that glutamine metabolism was …
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A Platform for Fast Detection of Let-7 Micro RNA Using Polyaniline Fluorescence and Image Analysis Techniques
… of probes causing PANI fluorescence to return to basal levels. By monitoring restoration of base PANI fluorescence as little as 10<sup>-11</sup> M (10 pM) of target oligonucleotides could be detected within 15 minutes of hybridization. Detection of complementary oligos was specific, with …
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Novel magnesium influx pathways in isolated renal thick ascending limb cells
… was tested in magnesium-rich buffer solution. Basal [Me]; was 0.52±0.02 mM (mean ± S.E.) in normal cells and 0.27±0.03mM in magnesium-depleted cells. Cells cultured (16 h) in high magnesium media (5 mM) maintained basal [Me];, 0.48± 0.02 mM, in the normal range. The decrease of [Mg"Ji …
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Influence of Oral Contraceptives on Selected Hormonal and Metabolic Responses to Prolonged Submaximal Exercise in Moderately Active Women
… higher initial GH responses and lower PRL levels during exercise than the C group. Circulating PRL levels during exercise decreased from basal levels for all groups. Blood glucose levels, R values, and absolute amounts of CHO utilized were lower in OC groups compared to controls. GH and PRL …
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Post-Translational Modifications of the Paired Box Transcription Factor 7 (Pax7) in Satellite Cells During the Repair of Injured Skeletal Muscle
… 14 days post CTX injection, but had returned to basal levels by 21 days post CTX injection. From 4 through 14 days post injection Pax7 abundance was ∼592%, 204%, and 219% greater compared to control muscles. GCN5 abundance was ∼215%, 330%, and 213% greater from 4 through 14 days post …
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A study of the beneficial role of thiol antioxidant supplementation in various forms of glutathione deficiency
… fibroblasts were investigated for their basal levels of glutathione, following which selected cell lines were treated with NACA to assess if thiol supplementation can elevate GSH levels in these cells. In addition, this study also explored a newly developed model for glutathione …
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Modulation of human adipose-derived stem cells and dermal fibroblasts in co-cultures by activation of the IL-6 trans-signalling pathway via the soluble IL-6Rα receptor
… (rhIL-6Rα). In addition, secreted cytokine levels (TGFβ1, TGFβ3 and VEGF) and biomarker expression (TGF β1RII, SMAD2/3, SMAD 1/5/9 and SMA) were quantitated. Although both cell types secreted IL-6, ADSC basal levels were 100-fold that of DF. Both cell types expressed CD130 (gp130) signalling …
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The effects of graduated exercise at the piano on the pianist's cardiac output, forearm blood flow, heart rate, and blood pressure
… to exercise intensity and returned to basal levels within a five-minute recovery period. Strenuous piano exercise stresses the body in general, not just the active forearm muscles. The stress load placed on the heart by piano playing can be at least as great as that produced by a brisk …
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