Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"basal layer"”.
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Identify and characterise stem cell population of the human endometrium
… In a menstruating endometrium, the functional layer is sloughed off during each cycle whilst the basal layer, which contains the potential for endometrial regeneration remains intact. Cyclical and functional changes of the endometrium are regulated by the production of oestrogen and …
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The role of translation in keratinocyte cell fate determination.
… proliferating progenitor cells localised in the basal layer of the tissue. While progenitor cells normally remain in the basal layer throughout their lifetime, differentiating cells move up the tissue and are eventually shed off, helping to maintain tissue homeostasis. Cultured human …
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Comparação dos aspectos histomorfométricos entre lesões de líquen plano oral e lesões liquenoides orais
… and eosinophilic band, degeneration of the basal layer and involvement of the epithelium-chorion interface and degree of subepithelial inflammatory infiltrate, and morphometric parameters, such as keratin thickness, distance from the basal layer to the epithelial surface, thickness of the …
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The Study of Serial Histochemical Changes in Laser-related Post-inflammatory Hyperpigmentation
… and eosin staining showed vacuolar change on the basal layer and dermal edema immediately after irradiation, which were fully recovered over 28 days. Fontana-Masson staining showed that melanin pigment was removed and detected on the corneal layer as extracellular melanin. At day 28, either …
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Fibre-optic borehole observations and numerical modelling of complex ice-sheet thermodynamics
… of these ice-motion patterns through a basal layer of temperate ice (much softer ice at the pressure-melting point). I first present a fibre-optic data set from a 1,043 m deep borehole drilled to the base of the fast-moving (>500 m a‾¹) marine-terminating Sermeq Kujalleq (Store Glacier) …
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The Skin Remembers: Epigenetic Memories of Inflammation Past
… stem cells (EpSCs). EpSCs reside in the basal layer of the skin, survive long-term, and are capable of both self-renewing and differentiating into multiple skin lineages. To efficaciously maintain the barrier, EpSCs must be able to sense and respond to environmental cues. Here, I unearth …
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HPV E6 inhibits E6AP to regulate epithelial homeostasis by modulating keratinocyte differentiation commitment and YAP1 activation
… infections by modulating homeostasis of infected basal cell to ensure persistence. Using FUCCI and cell-cell competition assays, we established the role of two common viral targets of low-risk and high-risk E6 proteins, E6AP and NHERF1, on the key components of epithelial homeostasis: cell …
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Transcriptional functions of the corepressor Sin3A in skin
… model in which Sin3A is inducibly deleted in the basal layer of the epidermis. Deletion of Sin3A resulted in a severe disruption of epidermal homeostasis-namely due to increases in proliferation and differentiation. Further investigation demonstrated that this phenotype is driven by enhanced …
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Investigating Early Lesion Formation Following Papillomavirus Infection Using a Mouse Model and Cell Culture
… tissue analysis suggested a modulation of basal cell density in infected epithelium, and a delay in normal differentiation commitment in E6/E7 expressing cells. Whole genome cell culture experiments were attempted in parallel with human high-risk types, which showed a post-confluent effect …
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Identification and characterization of the gene responsible for the <em>matted</em> mouse phenotype
… into toughened corneocytes begins in the basal layer of the epidermis and culminates in the formation of the stratum corneum (SC). Corneocytes are terminally differentiated cells which form a protective shield consisting of insoluble structural proteins cross-linked to the lipid envelope …
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The expression of Heat Shock Protein 70 in the placental tissue with preeclampsia
… endothelial cells, extravillous trophoblast in basal layer and decidual cell. And according to the intensity of immunostaining, we compared these three groups. Western blot analysis was performed and the quantification and comparison of Hsp70 were done in placental tissue among the three group …
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Novel Biophotonic Imaging Techniques for Assessing Women's Reproductive Health
… average nuclear diameter found by a/LCI in the basal layer of ectocervical epithelium showed a statistically significant increase in size in dysplastic tissue. These results indicate that a/LCI is capable of identifying cervical dysplasia in ectocervical epithelium. The results of the work …
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Transcriptomic and Proteomic Studies of Intercellular Communication Between Melanocytes and Keratinocytes in Human Skin
… Interspersed amongst the keratinocytes in the basal layer of the epidermis are melanocytes, the pigment producing cells of the epidermis. Melanocytes produce melanin pigment which resides in melanosomes, organelles that are transferred to keratinocytes. In my thesis work, I focused on …
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Immunohistochemical Evaluation and Gene Expression Profiling of Senile Lentigo
… are characterized by hyperpigmentation in the basal layer of the epidermis, combined with elongation of rete ridges. The molecular pathogenesis underlying the initiation and formation of senile lentigines are not completely understood. The histological and immunohistochemical features that …
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Understanding and Targeting Clearance of Persistent HPV Infections
… vitro model systems were developed to mimick the basal/suprabasal layers of the epithelium and evaluate HPV E6 functions in modulating cellular environment based on either the expression of a real-time cell cycle indicator (FUCCI) and early differentiation marker (KRT10); or the competition …
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Dissecting the Functions of Classical Cadherins in Skin
… of P-cadherin in the E-cadherin null epidermal basal layer but not the hair follicle. To formally test this premise, I have examined the in vitro and in vivo consequences of E- and P-cadherin inhibition. Suppression of classical cadherins blocked epidermal sheet formation in vitro, while …
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Interaction of Bacillus Anthracis Exosporium Protein Bcla With Complement Factor H and Spore Persistence In The Lung
… enclosed by an exosporium, which consists of a basal layer surrounded by a nap of hair-like filaments. The major structural component of the filaments is called <em>Bacillus</em> collagen-like protein of <em>anthracis </em>(BclA), which comprises a central collagen-like region and a globular …
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Induction of hair follicles using neonatal mouse dermis and human keratinocytes: relevance for improved burn wound treatments
… foreskin keratinocytes expressed high levels of basal layer marker, keratin 5 (K5), and low levels of the early differentiation marker, K10, suggesting that the isolated keratinocytes have stem cell properties. When co-cultured with neonatal mouse mesenchymal cells using Transwells, the …
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Rapid Functional Dissection of Genetic Networks Via RNAi In Mouse Embryos
… cells were primarily localized in the suprabasal cells. I found that cells lacking α-catenin showed elevated focal adhesion signaling, and using the lentiviral knockdown approach, I found that co-depletion of focal adhesion signaling components reduced the protection from apoptosis afforded …
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Tear film structure of the contact lens wearer
… light, allows the measurement of tear film layer thicknesses and on the surface of rigid contact lenses and invivo receding contact angle'. 2. A low magnification technique of photography allows the record i rig and the analysis of the superficial layers of the tear film over aw ice area of …
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