Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 130 for “"basal ganglia."”.
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Beyond the basal ganglia
… research has mainly focused on the role of the basal ganglia. Dysfunction of these brain nuclei likely underlies motor disturbances in HD, including the conspicuous, uncontrollable, dance-like movements (chorea). However, HD is frequently complicated by other important signs and symptoms that …
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Speech disorders and lesions of the Basal Ganglia
… speech disorders consequent upon lesions of the basal ganglia. For many years it was assumed that the speech disorders associated with basal ganglia damage were no more than a manifestation of underlying rigidity. However, experience has shown that surgery which successfully ameliorates the …
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Social Cognition in Disorders of the Basal Ganglia
Patients with disorders of the basal ganglia, such as Parkinson’s disease, Huntington’s disease and Tourette’s Syndrome, exhibit characteristic motor symptoms and less obvious cognitive deficits. These deficits can be understood with reference to the model of cortico-striato-thalamo-cortical …
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Functionally relevant basal ganglia subdivisions in first-episode schizophrenia
… yet the pathophysiology remains unclear. The basal ganglia, a region of the brain involved in motor, cognitive, and sensory processes, may be involved in the pathophysiology of schizophrenia. Some, but not all, neuroimaging studies suggest abnormalities of the basal ganglia in schizophrenia. …
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Pathobiology of neuroinflammation and basal ganglia circuitry in Parkinson’s Disease
… progressive death of dopaminergic neurons in a basal ganglia nucleus termed the substantia nigra (SN). Another hallmark feature of PD pathology is the presence of Lewy bodies and Lewy neurites, which are cellular inclusions with aggregated protein depositions, representing pathology in neuronal …
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Cortical - Basal Ganglia Circuits: Control of Behaviour and Alcohol Misuse
… form and unite to link the cortex with the basal ganglia and thalamus to mediate movement, cognition and behaviour. Previous assertions that the basal ganglia primarily acted to filter cortical information to facilitate motor outputs only have since given way to an understanding of the basal …
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Multiple stages of sensorimotor processing in the primate basal ganglia
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 1992.
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Muscarinic cholinergic receptors in the developing and mature basal ganglia
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 1988.
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The Role of the Cortico-Basal Ganglia-System in Voluntary Movements
… recordings of motor circuits in the cortex and basal ganglia in the consciously behaving rodent during the execution of various motor behaviors. To be able to further explore the relevance of neuronal activation patterns for different behaviours within these motor structures, we developed two …
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Neural Dynamics in the Basal Ganglia Underlying Birdsong Practice and Performance
… to demonstrate that spiny neurons (SNs) in the basal ganglia (BG) encode vocal variability during solo practice, and that SN activity is strongly suppressed to enable stereotyped song performance towards a female. Second, I showed that optogenetically inhibiting SNs reduces pitch variability to …
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The Role of the Basal Ganglia in Memory and Motor Inhibition
This PhD thesis investigated the role of the basal ganglia in memory and motor inhibition. Recent neuroimaging evidence suggests a supramodal network of inhibition involving the lateral prefrontal cortex. Here we examined whether this supramodal network also includes subcortical structures, such as …
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Perceptual Organization in Parkinson’s Disease: A Behavioral Investigation of Basal Ganglia Dysfunction
The basal ganglia provide a major neural system through which the cortex affects behavior. Most notable among these effects are those related to the voluntary control of movement as seen in neurodegenerative disorders like Parkinson’s disease (PD). Well known tests of visual perception in PD …
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Modeling the role of the basal ganglia in motor control and motor programming
The basal ganglia (BG) are a group of highly interconnected nuclei buried deep in the brain. They are involved in an important range of brain functions, including both lower-level movement control and higher-level cognitive decision making. Dysfunction of the BG has been linked to human …
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The role of basal ganglia-forebrain circuitry in the vocal learning of songbirds
The basal ganglia form the largest sub-cortical structure in the human brain and are implicated in numerous human diseases. In songbirds, as in mammals, basal ganglia-forebrain circuits are necessary for the learning and production of complex motor behaviors; however, the precise role of this …
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The role of frontal cortical-basal ganglia circuits in simple and sequential visuomotor learning
… recording and lesioning studies implicate the basal ganglia and anatomically related regions of frontal cortex in visuomotor learning. Two experiments were conducted to elucidate the role of frontal cortex and striatum in visuomotor learning. Several tasks were used to characterize motor …
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Haloperidol-Environment Interaction Modulates Expression of c-Fos Proteins in the Basal Ganglia in Rats
Inverse incentive learning is the loss by stimuli of their ability to elicit approach and other responses. This has been shown in the horizontal bar test. Rats in the Paired group (n = 10) were injected with haloperidol (0.25 mg/kg) and initially descended almost immediately but over days descent …
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The involvement of the primate frontal cortex-basal ganglia system in arbitrary visuomotor association learning
… of this thesis to examine the frontal cortex-basal ganglia system during arbitrary visuomotor association learning, the forming of arbitrary links between visual stimuli and motor responses (e.g. red means stop), a fundamental learning process that underlies much of our complex behavior such …
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Functional organisation of behavioural inhibitory control mechanisms in cortico-basal ganglia circuitry: implications for stimulant use disorder.
… were investigated, focusing on the cortico-basal ganglia circuits in rats and humans. These included behavioural flexibility, ‘waiting’ and ‘stopping’ impulsivity and involved serial spatial reversal learning task in rodents, and in humans, premature responses in the Monetary Incentive Delay …
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