Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"basal forebrain"”.
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Space and Value in the Primate Amygdala and Basal Forebrain
… with anatomically linked brain areas. The basal forebrain is a candidate brain area for interacting with the amygdala in influencing emotionally-guided attention given its anatomical connectivity and influence over attentional processes. Here, we analyzed data from amygdala and basal …
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The Role of the Infralimbic-Basal Forebrain Pathway in Fear Extinction
… understand how IL modulates extinction is the basal forebrain (BF).</p> <p>The BF both provides and receives input from IL and BLA and has been implicated in attention and learning, including in protocols encompassing inhibition of fear responses such as fear discrimination. The role of BF-BLA …
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Regulation of Circadian Rhythms by Sleep -Wake Centers in the Brainstem and Basal Forebrain
… these processes interact is unknown. The nucleus basalis magnocellularis (NBM) in the basal forebrain, as well as the laterodorsal tegmental and pedunculopontine tegmental nuclei in the brainstem are known to play a role in regulating the sleep-wake cycle, and contain projections to the SCN. In …
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Effects of Environmental Temperature on Sleep and Waking in Normal Rats and Rats With Basal Forebrain Damage
Damage to the basal forebrain (preoptic area and surrounding structures) causes hyposomnia and impairs body temperature regulation. Normal sleep is sensitive to thermal stress--animals spend the most time asleep at thermoneutral temperatures, and amounts of sleep decline in the heat and in the …
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Fas-associated factor 1 is involved in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice
PART I 1 Ⅰ. INTRODUCTION 2 A. Basal forebrain of mammals 2 B. Neuron types in the basal forebrain 2 C. Alzheimer’s disease 3 D. Normal functions of tau protein 4 E. Structure and Posttranslational Modifications of the Tau Protein 5 F. Distribution of tau phosphorylation sites and NFT …
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Interactions of Thyroid Hormones and Nerve Growth Factor in Normal Development of the Rat Hippocampus and Basal Forebrain and in Recovery From Early Hypothyroid Retardation
… NGF results in decreased trophic support for basal forebrain cholinergic neurons, leading to a compensatory up-regulation of NGF receptors. Thyroid hormone normalization restores total hippocampal NGF, causing hypertrophic growth responses in both the basal forebrain and hippocampal formation. …
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Age-Related Alterations in Orexin Modulation of Septo-Hippocampal Neurotransmission
… hippocampus and the medial septum (MS) of the basal forebrain. Within the MS, orexin innervates cholinergic and GABAergic parvalbumin (PV) containing neurons that project to the hippocampus via the septo-hippocampal pathway. This anatomy suggests that orexin exerts transsynaptic control of …
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Mapping the substrate for brain stimulation reward : new approaches to an old problem
… produced by electrical stimulation of the medial forebrain bundle (MFB). This objective was addressed by combining immunohistochemical, lesion, and behavioral methods. Immunohistochemical staining of the immediate early gene product, Fos, was used to visualize neurons activated by rewarding …
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Role of prefrontal cortex and cholinergic modulation in attentional performance in rats
… validated the role of the ascending cholinergic basal forebrain system in 5-CSRTT performance. These findings support 1. the idea of the relationship between cholinergic system activation and attentional performance to resemble an ‘inverted-U’ shaped function; 2. a double dissociation of mPFC …
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Effects of tumor necrosis factor alpha on nitric oxide synthase in nerve growth factor-responding cells
… injection of TNFa, which was restricted to the basal forebrain and hippocampus. No iNOS expression was detected in the striatum, or cerebellum. Determining whether the role of TNFa is one key to the selective neurodegeneration of NGF-responsive neurons in may allow for novel therapeutic …
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Cell-type specific cholinergic modulation of the cortex
… by afferent fibers originating in the nucleus basalis (NB) of the basal forebrain is implicated in modulating diverse neocortical functions including information processing, cortical plasticity, arousal and attention. To understand the physiological basis of these brain functions during …
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Cholinergic Control of Cortical Circuit Activity
<p>Cholinergic neurons of the basal forebrain send extensive projections to all regions of the neocortex and are critically involved in a diverse array of cognitive functions, including sensation, attention and learning. Cholinergic signaling also plays a crucial role in the moment-to-moment …
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Non-Photic Phase Shifting: Acetylcholine and Arousal
… specifically in cholinergic cells of the forebrain is increased in animals undergoing novel wheel confinement, but not sleep deprivation. It was then found that in vivo electrical stimulation of the basal forebrain region containing cholinergic neurons phase advanced circadian rhythms of …
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The role of the GABAergic system in the production of ultrasonic vocalization in rats /
… it is known that chohnergic input to the basal forebrain induces such alarm calls. A number of experiments have found that intracerebral injection of carbachol, a predominantly muscarinic agonist, into die anterior hypothalamic/preoptic area (AH/POA) rehably induces vocalization similar to …
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Neurofunctional Characterization of the At-Risk Mental State for Psychosis
… in the bed nucleus of the stria terminalis/basal forebrain (BNST), anterior cingulate cortex (ACC), and medial prefrontal cortex (mPFC) in response to neutral faces. Collectively, these experiments show that neurofunctional deficits in reward-anticipation, hippocampus-dependent learning, and …
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Investigating the neurobiology regulating cognitive effort allocation using a rodent model of cost/benefit decision making
… to downregulate cholinergic neurons of the basal forebrain as rats perform the rCET, to determine whether this neuronal population is responsible for the previously ascribed role of acetylcholine in regulating decision making with cognitive effort costs. Experiments 2 and 3 use standard …
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Grey matter morphological changes in late life using magnetic resonance imaging technique
… the characteristics of the ageing brain. The basal forebrain area (BFA) is closely connected to the hippocampus by virtue of cholinergic neuronal projections. Structural neuroimaging studies have shown reduced volumes of both structures in mild cognitive impairment (MCI); however, of interest …
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Cognition in healthy aging and Parkinson's disease : structural and functional integrity of neural circuits
… tools that visualize the SNc and the cholinergic basal forebrain (BF). We applied these methods to test the hypothesis that degenerative processes in PD affect the SNc before the BF. This experiment lays important groundwork for future studies that will examine the relative contribution of the SNc …
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Hypothalamic Circuits Mediating Consumption and Anxiety
… (LH) inhibit GABAergic anxiety neurons in the basal forebrain (BF). Activating this circuit causes feeding and reduces anxiety; fiber photometry shows LH neurons are active both during food approach and food consumption, but BF neurons only drop in activity during eating. Conversely, BF neurons …
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Identification and Delineation of Neuronal Pathways Underlying Hypophagia
… targeting an excitatory brain circuit from the basal forebrain (BF) to the ventral tegmental area (VTA). The BF is recognized as a sensory hub that incorporates environmental information and the VTA is a well-known reward-processing center. This project is associated with driving anorexia-like …
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