Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 132 for “"barrier function"”.
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Improving the skin barrier function in atopic dermatitis
… with genetic mutations affecting the epidermal barrier protein filaggrin. Filaggrin aggregates keratin filaments during terminal keratinocyte differentiation, allowing normal epidermal stratification. The role of filaggrin in maintaining a functional skin barrier is further supported by a …
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Regulation of COX-2 and PGE2-Dependent Recovery of Intestinal Barrier Function
The regulation of intestinal barrier function is of importance in various clinical situations. For example, in cases of ischemia/reperfusion injury, there is a disruption in the gastrointestinal barrier. This may lead to release of pro-inflammatory cytokines and neutrophil (PMN) infiltration. It …
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Characterizing various aspects of the male genital tract barrier function and immunity
… strategies. This PhD thesis examines barrier function, the density of HIV target cells and various expressed epithelial barrier proteins and genes in different anatomical sites of the intact penis before VMMC and in foreskin tissue after surgical removal. How these measurements are …
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The gut microbiome: A key regulator of mucosal tolerance, barrier function, and vaccine response
… in modulating the integrity of the intestinal barrier, highlighting the critical role of microbiota in both maintaining epithelial homeostasis and shaping immune responses in the context of immunization. Additionally, this work delves into the complex relationship between microbiota composition …
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Intrinsic alterations of the skin barrier function promote the pathogenesis of atopic dermatitis in dogs
… in atopic people is due to defects in the skin barrier function such as deficiency of keratinocyte-secreted natural antimicrobial peptides (AMPs) and filaggrin. Antimicrobial peptides are small proteins secreted by many mammalian epithelial cells. Their main functions include: defense against …
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The Effect of Novel Anti-inflammatory Drugs on the Cyclooxygenase Enzymes and Recovery of Mucosal Barrier Function
… of prostaglandin E2 (PGE2) and the recovery of barrier function, robenacoxib allowed barrier function to recovery and production of PGE2. The mechanism of action of the novel anti-inflammatory compound AHI-805 is currently unknown. Using an in vitro equine whole blood model, the effect of …
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INTERACTIVE EFFECT OF DIETARY FIBRE AND IMMUNE CHALLENGE ON THREONINE REQUIREMENT AND INTESTINAL BARRIER FUNCTION IN GROWING PIGS
… may also play an important role in intestinal barrier function. Therefore, this thesis evaluated the independent and combined effects of high DF and immune challenge [Salmonella typhimurium and systemic E. coli lipopolysaccharide (LPS)] on the Thr requirement for PD and growth in pigs, and on …
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The Cx43 Carboxyl-Terminal Mimetic Peptide αCT1 Protects Endothelial Barrier Function in a ZO1 Binding-Competent Manner
… in regulation of epithelial/endothelial barrier function. Using both in vitro and ex vivo methods of barrier function measurement, including Electric Cell-Substrate Impedance Sensing(ECIS), a TRITC-dextran transwell permeability assay, and a FITC-dextran cardiovascular leakage protocol …
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Engineering the tumor microenvironment using microfluidics : effects of cell-cell interactions and endothelial barrier function on tumor cell intravasation
… combined with quantitation of the endothelial barrier function. Compared with traditional in vitro assays, microfluidic assays enable "user-defined" design of the cellular and acellular microenvironment with spatio-temporal control and live high-resolution imaging. Formation of confluent …
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Mechanisms of Prostaglandin-Stimulated Recovery of Mucosal Barrier Function in the Ischemia-Injured Porcine Intestine: Role of Intestinal Ion Transport
… of individual Cl- channels in the recovery of barrier function in ischemia-injured porcine ileum. Ischemia-injured porcine ileal mucosa was mounted in Ussing chambers. Short circuit current (Isc) and transepithelial resistance (TER) were measured in response to PGE2 and pharmacologic inhibitors …
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Effects of fructan source and degree of polymerization on intestinal barrier function and histomorphology characteristics in obese C57BL/6 mice
… and non-fermentable fibers affect intestinal barrier function.
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¿CHIOS MASTIC GUM FROM PISTACIA LENTISCUS AS A MODULATOR OF INFLAMMATION AND INTESTINAL BARRIER FUNCTION: AN IN VITRO AND CLINICAL INVESTIGATION.¿
… inflammation and impaired intestinal barrier function. Although effective, current therapies present limitations, highlighting the need for complementary approaches. Chios Mastic Gum (CMG), a resin from Pistacia lentiscus, has shown anti-inflammatory and barrier-protective properties …
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Tie-ing the endothelium: development of an mRNA-based nanotherapeutic to restore microvascular barrier function for the treatment of sepsis-induced multiple organ failure
… approaches to treat sepsis. Endothelial dysfunction is a hallmark of sepsis to which the loss of Ang/Tie2 signalling, a key regulator of vascular integrity, contributes significantly, making it an attractive therapeutic target. The impairment in Tie2 pathway activity manifests most …
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Purinergic Signaling Regulates Filopodia-Induced Zippering
… A2B (A2BR) induces cell-cell adhesion to promote barrier function. This barrier function is known to be important in maintaining homeostasis during hypoxia, trauma, and sepsis. Loss of this epithelial barrier function provides a considerable advantage for carcinoma progression, as loss of …
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Follow your gut: Does AKR1D1 impact gastrointestinal health?
Dysfunction of the gut-liver axis contributes to non-alcoholic fatty liver disease (NAFLD) pathogenesis and progression. Bile acid homeostasis is disrupted in NAFLD, and this has been suggested to increase cytotoxic bile acids species in the intestine, disrupt cytoprotective intestinal bile acid …
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FUNCTIONAL ADAPTATION OF THE RUMINAL EPITHELIUM
… SCFA absorption, and thus is a key indicator of functional changes in the rumen epithelium. The objectives of this study were to determine the time required for a change in SCFA and Na+ absorption across the bovine rumen epithelium and to evaluate the rate and degree to which absorption pathways …
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Monitoring Tissue Function Dynamics in vitro with Bioelectronics: Towards Understanding Barrett’s Oesophagus Pathogenesis
… gastro-oesophageal reflux, which impairs mucosal barrier function, leading to epithelial ulceration, and initiates a sustained inflammatory response. This complex microenvironment reprogrammes both local cell types as well as the BE progenitor *cell of origin* (the identity of which remains under …
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