Global ETD Search
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Showing 1 to 14 of 14 for “"barrett's oesophagus"”.
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Clonal Dynamics in Barrett's Oesophagus and Oesophageal Adenocarcinoma
… stage. OAC has a metaplastic pre-cursor lesion, Barrett’s oesophagus (BO), which can be monitored and effectively treated if dysplasia develops. Screening for BO could improve outcomes but needs to be balanced with the consequences of over-diagnosis and over-treatment since most BO will not …
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Biomarkers of Progression from Barrett's Oesophagus to Oesophageal Adenocarcinoma
Barrett’s oesophagus (BO) is a pre-malignant condition for oesophageal adenocarcinoma (OAC) [1], the incidence rate of which has been rising dramatically over the last four decades in the western world [2, 3]. Survival of an OAC affliction is poor, and one of the ways to improve this would be by …
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A Study to Investigate Factors Involved in the Development of Oesophageal Carcinoma
… true for patients with the precursor lesion, Barrett's oesophagus. The current study considered the hypothesis that patients with Barrett's oesophagus were deficient in antioxidants compared to reflux patients without evidence of Barrett's oesophagus.<br/><br/>Bcl-2 is an inhibitor of …
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Identification of Two Novel Genome-Wide Significant Single Nucleotide Polymorphisms, associated with Barrett’s Oesophagus, determined by further Replication of a Genome-Wide Association Study
Barrett's oesophagus (BE) is a common premalignant condition to oesophageal adenocarcinoma (EAC). A previous genome-wide association study (GWAS) identified BE susceptibility Single Nucleotide Polymorphisms (SNPs) on chromosome 6p21, within the HLA region, and16q23, where the closest protein-coding …
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The involvement of bacteria in the progression of Barrett’s oesophagus to adenocarcinoma of the oesophagus
Barrett's oesophagus (BO) arises from chronic gastro-oesophageal reflux disease(GORD). Patients have an increased risk of adenocarcinoma (ADC), which is the sixth most common cause of cancer mortality in the UK. All ADC develop from BO, and over the last twenty years there has been a marked …
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Characterisation of Copy Number Changes in the Progression of Barrett’s Oesophagus
… the development of oesophageal adenocarcinoma is Barrett’s oesophagus (BE). To diagnose those patients who will progress to cancer early to improve the dismal survival rate of oesophageal adenocarcinoma, patients with BE undergo regular endoscopic surveillance. The vast majority of patients, …
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The Use of 2D and 3D Models to Study Competition in the Context of Barrett’s Oesophagus and Oesophageal Adenocarcinoma
… through an identifiable pre-cursor stage, Barrett’s Oesophagus (BO). BO can progress via the accumulation of further genetic and morphological changes into low-grade and then high-grade dysplasia. This development process is believed to take place over many years or decades and offers …
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Integrating Epidemiological and Genomic Factors to Inform Outcomes in Barrett’s Oesophagus and Oesophageal Adenocarcinoma
… increased, and its prognosis remains poor. Barrett’s oesophagus (BO) is considered the precursor to OAC, however, BO is not apparent adjacent to tumour in nearly half of OAC patients. We have previously demonstrated that patients with BO-adjacent tumours (BO+ve OAC phenotype) have a …
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Multi-omic characterisation of Barrett’s oesophagus reveals a molecular continuum in the progression to oesophageal adenocarcinoma
Barrett’s oesophagus (BE) is the main risk factor for the development of oesophageal adenocarcinoma (OAC) yet only 0.4%/year of non-dysplastic (ND) BE cases progress to cancer (Bhat et al., 2011). In this thesis I present the first comprehensive, multi-omics study comparing indolent, …
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Novel Optical Endoscopes for Early Cancer Diagnosis and Therapy
… endoscopes for detection of dysplasia in Barrett’s oesophagus. To enable molecular imaging with a newly discovered targeted fluorescent contrast agent, a bimodal endoscope capable of capturing NIR fluorescence and white light reflectance was developed around a clinically translatable …
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Monitoring Tissue Function Dynamics in vitro with Bioelectronics: Towards Understanding Barrett’s Oesophagus Pathogenesis
Barrett’s oesophagus (BE) is a non-malignant, specialised intestinal metaplasia of the oesophageal mucosa and a precursor of oesophageal adenocarcinoma (EAC). EAC is a particularly aggressive cancer with a high mortality rate, and as such, early intervention and prevention is considered to be …
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Deep learning on whole-slide images for early detection and risk prediction of oesophageal cancer
… at particularly high risk for progressing from Barrett’s oesophagus (BE) to oesophageal adenocarcinoma (EAC) earlier and more accurately using data from a minimally-invasive cell collection device. It also introduces a new software library for efficiently handling computational pathology tasks. …
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Probabilistic modelling of somatic alterations in bulk tissue and single cells using repeat DNA
Chromosomal instability characterises several cancer types, in which large-scale structural alterations of the genome accumulate at an increased rate. An important class of structural alterations are somatic copy number alterations (SCNAs). SCNAs have been shown to be major drivers of oncogenesis …