Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 18 of 18 for “"barrel cortex"”.
-
Modulation of Barrel Cortex Microcircuitry by Serotonin
Contains fulltext : 165625.pdf (Publisher’s version ) (Open Access)
-
The Role of Perineuronal Nets in Regulating Barrel Cortex Physiology
… PNNs are relatively ubiquitous in the neocortex, little is known about the degree to which they impact the physiology of the diverse neuronal phenotypes that exist there. This research focused on determining the experience dependent maturation of PNNs in different cortical layers and …
-
Age-Dependent Effects Of Chronic GABAA Receptor Blockade In Barrel Cortex
… binding is transiently increased in rat whisker barrels during the second postnatal week, at a time when neurons in the developing rat cortex are vulnerable to excitotoxic effects. To test whether these GABAA receptors might serve to protect neurons from excessive excitatory input, polymer …
-
Spatio-temporal structure of thalamically evoked activity in the barrel cortex
The barrel cortex integrates incoming information conveyed via thalamocortical pathways and ongoing activity thereby extracting the relevant details from spatio-temporal dynamic stimuli that carry information about the environment. In the course of this, the cortical response to the incoming …
-
A study of glutamate receptor function in the rat barrel cortex
Bibliography: leaves 137-156.
-
Calcium dynamics in dendrites and spines of spiny neurons in the somatosensory ‘barrel’ cortex of the rat
… of spiny neurons of layer 4 of the somatosensory cortex in acute thalamocortical brain slices of young (P13-P15) rats. Back-propagating action potentials (bAPs) resulted in a transient rise in Ca2+ in all dendrites and spines tested, representing a global intracellular chemical signal about the …
-
BDNF and Astrocyte TrkB.T1 Signaling as a Mechanism Underlying Astrocyte Synapse Interactions in Motor and Barrel Cortex
… astrocyte-synapse interactions in the motor and barrel cortex. Mechanistic studies using neuron-astrocyte co-cultures also reveal that loss of TrkB.T1 in astrocytes inhibits the formation of PAPs around glutamatergic synapses. Altogether, the insights presented herein present a novel …
-
Molecular-Genetic and Behavioral Analysis of the Functionality of Patterning in the Trigeminal Neuraxis
… in rodents is the presence; at brainstem (barrellettes), thalamic (barrelloids) and cortical levels (barrels) of a somatotopically organized pattern of neurons which is isomorphic, both morphologically and physiologically, to the pattern of vibrissae on the snout. The vibrissal system is …
-
A More General Role for the Fragile X Mental Retardation Protein in Pruning of Both Synaptic and Dendritic Processes
… retraction in both somatosensory whisker barrel cortex and olfactory bulb of FraX mice. Further analysis of both normal development and anatomical and metabolic activity in somatosensory whisker barrel cortex using nissl and cytochrome oxidase staining demonstrated; (2) elevated fmr1 …
-
Characterization of CPG15 during cortical development and activity dependent plasticity
… maturation, is regulated in the somatosensory cortex by sensory experience capable of inducing cortical plasticity. Using in situ hybridization, we monitored cgp15 expression in 4-week-old mouse barrel cortex after trimming all whiskers except D1. We found that cpgl5 expression is depressed in …
-
Neocortical Layer 4 to Layer 2/3 Sensory Information Processing Investigated with Digital-Light-Projection Neuronal Photostimulation
… integration of synaptic input in the whisker barrel cortex of mice. The neocortex is organized into layers, with neuronal networks and circuits formed by layer-specific connections. While the anatomical organization of these circuits has been well characterized, the information processing and …
-
Phenotypic And Electrophysiologic Characterization of a Mouse Model of Fragile X Syndrome
… to evaluate the functional properties of the neocortex. Pyramidal neurons in the neocortex of human FXS patients and Fmr1 KO mice are characterized by abnormally long, thin and numerous dendritic spines. Multiple electrode recordings were used to study how loss of Fmr1 expression affects several …
-
Dissecting the Physiological Roles of ULK1/2 in the Mouse Brain
… and disorganization of the somatosensory cortex. The axon guidance defects observed in Ulk1/2 double knockout (dko) and in CNS-specific (Nestin-Cre) Ulk1/2 conditional double knockout (cdko) mice were not recapitulated in mice lacking other autophagy genes (i.e. Atg7 or Fip200), and was …
-
Subcortical Inputs Governing Cortical Network Activity
Sensory information is represented in cortex by cascades of excitation, the patterns of which are constrained and biased by anatomical connections between neurons. Additionally, in the living animal, functional connectivity is dynamically adjusted by internally generated background activity, which …
-
Systematic examination of the impact of pre-stimulus alpha- mu and gamma band oscillations on perception : correlative and causal manipulation in mouse and human
… system throughout is primary somatosensory neocortex and tactile perception: I combine studies from human and mouse to benefit from the relative merits of each preparation. Several prior studies support this more generally stated view of oscillatory dynamics -- alpha predicting diminished and …
-
Examination of neocortical plasticity during forebrain-dependent trace-associative learning tasks
… because it requires an intact neocortex and hippocampus (Solomon et al., 1986; Moyer et al., 1990; Kim et al., 1995; Weiss et al., 1999a; Takehara et al., 2002; Galvez et al., 2007). Using the trace-eyeblink conditioning paradigm with whisker stimulation as the CS …
-
Localization and Function Of RNA Interference in the Cerebral Cortex
… to influence plasticity of the mouse vibrissal barrel cortex. In this model system, chronic whisker plucking reliably leads to the expansion of the cortical representation of the adjacent non-deprived whiskers. The mechanism underlying this process involves changes in synaptic efficacy and …
-
The Long-Term Teratogenic Effect of Prenatal Alcohol Exposure on the Somatosensory and Motor Cortex of Rats
… the primary somatosensory (SI) and primary motor cortex (MI). For over 30 years, PAE has been shown to produce a triad of symptoms (growth deficits, craniofacial dysmorphologies and central nervous system disruptions) diagnosed as fetal alcohol syndrome (FAS) in children and adults. Since low to …