Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"bacteriocins"”.
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Bacteriocins of staphylococci and oral streptococci
Contains fulltext : mmubn000001_250491249.pdf (Publisher’s version ) (Open Access)
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Design and Discovery of Novel Bacteriocins
… subjects of this thesis, 4-Helix Bundle (4-HB) Bacteriocins, are a small group of potent antimicrobials produced within the bacterial communities which share a common topology and physicochemical properties, and the few reported examples have demonstrated promising therapeutic potential.<br>A …
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Characterisation of novel bacteriocins from canine sources
… resistance (AMR) and the potential for bacteriocins as an alternative or adjunct to traditional antibiotics. More specifically, this thesis explores the class Ia bacteriocins termed lantibiotics, and the identification and characterisation of novel bacteriocins from canine sources. …
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Biomedical applications for bacteriocins in infection and oncology
… produced antimicrobial peptides called bacteriocins. They are characterized by post-translation modifications resulting in the presence of unusual amino acid residues such as dehydroalanine (Dha), dehydrobutyrine (Dhb) and lanthionine/ methyllanthionine. Interest in using bacteriocins as …
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Discovery and evaluation of novel and characterised bacteriocins for future applications
Bacteriocins are a heterogeneous group of small, ribosomal-synthesised, antimicrobial peptides produced by bacteria, capable of inhibiting bacteria both closely related or indeed those from other genera than the producer. These peptides are often active in the nanomolar range making them highly …
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Computational Insights into the Antimicrobial Mechanism of Action of Class II Bacteriocins.
… including discovery of alternative drugs. Bacteriocins are bacteria-produced, antimicrobial peptides that are potentially powerful antibiotic drug candidates. Despite considerable scientific interest around bacteriocins, and despite their promise as potent, latent antibiotics, their …
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Bacteriocinogenic potential of lactic acid bacteria isolates from artisanal fermented meat products
… viridescens 23 and 31 and the detection of bacteriocins related genes were performed; L. curvatus 12 and 36 e W. viridescens 23 were selected for the other analysis to evaluate the bacteriocinogenic potential. The selected isolates showed distinct growth and bacteriocin production was more …
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Identification et caractérisation de bactériocines produites par deux bactéries lactiques (Enterococcus faecium CWBI-B1430 et Enterococcus mundtii CWBI-B1431) isolées à partir de fromages frais artisanaux péruviens
… signal at 12, 30, 37 and 42°C. The production of bacteriocins on a small scale, in both strains was studied. It was investigate the influence of initial pH (4.5, 5.0, 5.5, 6.0, 6.5 and 7.0), temperature (25, 30 and 37°C) and oxygen level (anaerobic, microaerobic and aerobic). The conditions for …
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Alternative treatments for bovine and human mastitis
… in the treatment of human and animal infections. Bacteriocins, are a heterogeneous group of small, peptide-based bacterium antimicrobials that have either broad or narrow range inhibition spectra and as such are a viable alternative to antibiotics in some cases. This thesis presents the current …
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Characterisation and applications of bacteriocinogenic Isolates from the deep-sea fish microbiome
… Already, a limited number of novel bacteriocins from marine fish gut isolates have been identified and characterised. These include Formicin, a class I (lanthipeptide) bacteriocin from mackerel, several class IIa bacteriocins, and CAMT6, a very recently identified class IId …
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Avaliação do potencial biotecnológico de bactérias láticas para produção de biomulsificantes, bacteriocinas e lipase
… of biosurfactants/bioemulsifiers, lipase and bacteriocins. Initially, four strains of LAB were screened for their ability to produce biosurfactants/bioemulsifiers (Lactobacillus acidophilus NRRL B-4495, Lactiplantibacillus plantarum NRRL B-4496, Lacticaseibacillus rhamnosus EM1107 and …
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Potential of bacteriocin producing bacteria to control VRE infection
… need to develop therapeutic alternatives. Bacteriocins, small ribosomally synthesised peptides, have been proposed as one such alternative. Bacteriocins are non-toxic to producer strains and have been shown to exhibit antimicrobial ability against multi-drug resistant species including VRE …
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Detección y caracterización de péptidos con actividad antimicrobiana en aislados de Staphylococcus. Aplicación al ámbito agroalimentario y en salud pública
Bacteriocins have been considered an effective tool to address the problem of antibiotic resistance. Staphylococcus is normally found as commensal microorganisms of the nasal and skin microbiota of animals and humans, although some species can be opportunistic pathogens, especially S. aureus. …
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A deadly hug : contact-dependent killing by Caulobacter crescentus, via cell surface-associated glycine-zipper proteins
… or delivered in a contact-dependent manner. Bacteriocins are one ubiquitous type of such antimicrobials, and collectively constitute a very diverse group of ribosomally-synthesized diffusible proteinaceous toxins. The majority of well-characterized bacteriocin systems belong to a limited …
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Use of solution-state nuclear magnetic resonance spectroscopy to determine the structures of medicinally relevant peptides and proteins
… two peptide lantibiotic cytolysin, unique among bacteriocins in that it has hemolytic activity in addition to bactericidal activity. Nisin, the prototypical lantibiotic, was studied in the context of the immunity protein, NisI, which is believed to confer immunity against lysis to the producing …
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Comparative microbial genome analysis of lactobacilli
… immune systems, host interaction factors and bacteriocins that affect their natural and industrial environments, and mechanisms to withstand stress during technological processes. We present a robust phylogenomic framework of existing species and for classifying new species. In Chapter 3, we …
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Characterising vaginal Lactobacillus strains from young South African women with persistently optimal vaginal microbiota – Developing the framework for an African vaginal probiotic product development platform for reproductive health
… using the DefenseFinder tool. Lastly, putative bacteriocins were identified using BAGEL4. Results: The most common community state type (CST) identified across all participants and visits was the highly diverse CST IV, which is dominated by a variety of anaerobes and shows a strong association …
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An investigation into novel bacteriocin producers isolated for shelf life extension of dairy products
… peptides, and antimicrobial peptides known as bacteriocins which affect the product and the consumer are described. Chapter 2 outlines the production and techno-functional characterization of yoghurt produced using milk derived from different diets, perennial ryegrass (GRS) and total mixed …
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An in silico analysis of bacteriocin production in the human microbiota and its relationship with health
… of antimicrobials with this potential is the bacteriocins – antimicrobial peptides produced by many lineages of bacteria that kill or inhibit the growth of specific competitors. This thesis focuses primarily on the first step toward harnessing the bacteriocin-producing capacity of the human …
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Bioengineering of nisin to enhance functionality against dairy pathogens
… with this potential use in a clinical setting, bacteriocins also play an important role as bio-preservatives in the food industry. This thesis focuses on a specific bacteriocin group, the lantibiotics (Lanthionine-containing antibiotics). Their numerous methods of appliance in a food setting and …
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