Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"bactericidal effect"”.
-
Untersuchung der bakteriziden Wirkung von Nd:YAG-Laserstrahlung am Leitkeim Enterococcus faecalis in bovinem Dentin bei Pulsdauern von 15 und 25 ms : eine In-vitro-Studie
… of this in vitro study is to determine the bactericidal depth effect of laser irradiation with a wavelength of 1064 nm at pulse durations of 15 and 25 ms. Given that the success of endodontic treatment depends on the effective elimination of microorganisms from the root canal and this cannot …
-
Characterization of a transposon-induced pleiotropic metronidazole resistant mutant of Clostridium acetobutylicum P262
… is a pro-drug which must be reduced to elicit a bactericidal effect. In the clostridia, some of the electron transport proteins that provide the source of electrons for the reductive activation of metronidazole play a key role in electron distribution, which in turn regulates the direction of …
-
Discovery and functional evaluation of a host defense peptide from Rana amurensis
… Interesting, this peptide exhibited better bactericidal effect against E.coli (MBC=32 μM) than grampositive bacterium (S.aureus) (MBC=128 μM). Moreover, this peptide had less potency against C.albicans (MIC=512μM), along with low haemolytic activity (HC50< 512 μM). Also, peptide QUB-2566 had …
-
Novel Inhibitors for Isocitrate Lyase as a Potent Antitubercular Agent for Mycobacterium Tuberculosis
… a novel family of ICL inhibitors that is effective in vitro against both the enzyme and Mtb. Methods: The His-tagged ICL1 enzyme was expressed using E. coli as a host and purified by Ni-NTA chromatography. The recombinant enzyme was used to set up crystallisation trials and in vitro …
-
Inactivation of foodborne pathogens by fruit wines
… produced from grapes have been found to possess bactericidal properties on a number of pathogens in vitro, suggesting possible health benefits that may be derived from microbiological safety. This study investigated the bactericidal effects in wines made from fruits other than grape. The …
-
A bioactive peptide from the skin secretion of the Red-eyed Leaf Frog, Agalychnis callidryas
… μM. The results of MBC show that QUB-1541 has no bactericidal effect on E. coli and C. albicans at the highest concentration. However, QUB-1541 kills S. aureus at a lower level of 16 μM, while the haemolysis is weak. QUB-1541 was only effective against cancer cells, PC-3, U251MG and H157 at the …
-
Antibacterial activities of silver-nanoparticles-titania composite thin films fabricated by the molecular precursor method (MPM)
… Resonance (SPR) of Ag-NPs is ascribed to the effect. The antibacterial behaviors of resultant films were investigated against a gram negative bacterium, Escherichia coli as a model, both in the dark and under visible light by using the Antibacterial Susceptibility Testing method. Composite …
-
Early pathogenesis of Yersinia ruckeri infections in rainbow trout (Oncorhynchus mykiss, Walbaum)
… period. Analysis of the susceptibility to the bactericidal effect of rainbow trout serum demonstrated that virulent strains were serum resistant, whereas avirulent strains were generally serum sensitive. Taken together, adherence to mucus and resistance to the bactericidal effect of serum seems …
-
Autophagy and Inflammation During Rickettsial Infection
… of infection in mouse macrophages to escape the bactericidal effect possibly mediated by inflammatory cytokines including IL-1β. These data also suggest that rickettsiae interact with the autophagy system in cell-type specific mechanisms.
-
Combating Plague: Fighting a War on Two Fronts Through Vaccine Design and New Therapeutic Intervention
… not exhibiting any direct bacteriostatic or bactericidal effect on Y. pestis in vitro and having no modulating effect on crucial Y. pestis virulence factors, suggesting that DXP, AXPN, and TFP may modulate host cell pathways necessary for disease pathogenesis. Taken together, these results …
-
Post-harvest spray treatments to reduce Salmonella contamination on cantaloupe surfaces
… has a broad antimicrobial spectrum with a rapid bactericidal effect on Gram-positive pathogens. Delmopinol hydrochloride (delmopinol) is a cationic surfactant that is effective for treating and preventing gingivitis and periodontitis. The application of delmopinol or CPC to cantaloupe surfaces …
-
Development of Novel Synergistic Therapeutic Strategies to Combat Antimicrobial Resistance: Critical Roles for Natural Products
… envelope damage contributes to the synergistic bactericidal effect against VRE, for example, a 2.0-fold up-regulation of a lysM-domain containing protein (42912_B02_00848) indicates peptidoglycan structure alteration. Finally, the in vivo antimicrobial activity of the EO-vancomycin combination …
-
Bacterial inactivation using radial mode ultrasonic devices
… thermal and chemical methods has a detrimental effect on the nutritional value, taste and texture of the product. Also, bacteria are living organisms and as such are subject to evolution. In fact, the rate at which bacteria multiply probably makes them the fastest evolving organisms on the …
-
PKPD-Model Based Preclinical Characterization of the Activity of Spectinamide 1599 Against Mycobacterial Subpopulations. and the Identification of Potential Partners for Combination Therapy
… lack of cross resistance, long post antibiotic effect, and low toxicity potential. It also has a favorable pharmacokinetic profile and is primarily eliminated in the urine and thus has a low propensity for drug-drug interaction with other partner drugs. In addition, spectinamide 1599 has shown …
-
ANTIMICROBIAL CHARACTERIZATION AND THERAPEUTIC APPLICATIONS OF NOVEL SYNTHETIC THIAZOLE COMPOUNDS AGAINST MULTIDRUG-RESISTANT STAPHYLOCOCCI AND ENTEROCOCCI
… analysis. The compounds exerted a rapid bactericidal effect, targeting cell wall synthesis as deduced from Bacterial Cytological Profiling. Transposon mutagenesis suggested three possible targets: YubA, YubB and YubD. YubB is undecaprenyl diphosphate phosphatase (UPPP) and UPPP as well as …
-
A CONTRIBUTION TO THE STUDY OF BIOCONTROL AGENTS APITHERAPY AND OTHER POTENTIAL ALTERNATIVES TO ANTIBIOTICS
… of novel antimicrobial agents, which are effective against these pathogens has declined significantly. As a result, we urgently need effective alternatives to the use of antibiotics. The overall aim of the study was to add further our knowledge of some of these alternatives to antibiotics, …
-
Optimization of Lead Spectinamide Compounds as Novel Anti-tuberculosis Agents with a Pharmacometric Approach
… the selection and refinement of more potent and effective anti-TB spectinamides. Biopharmaceutical in vitro screening demonstrated that spectinamides in general have low plasma protein binding and are stable against hepatic microsomal metabolism. In vivo pharmacokinetic studies in rats revealed …
-
Strategies to potentiate bactericidal antimicrobial activity based on the suppression of bacterial stress response systems
… the SOS response has been shown to enhance the bactericidal activity of antimicrobials such as quinolones. Furthermore, bactericidal antimicrobials such as quinolones are also associated with the accumulation of reactive oxygen species (ROS) under aerobic conditions, inducing reactions that can …
-
Synthesis of monodisperse silver nanoparticles for antibacterial purposes
… than 10 nm had a negligible antibacterial effect in comparison to the ions they released. Thus, to isolate just the effect of the released silver ions, it was desired to prepare uniformly sized particles of smaller than 10 nm. Controlling the size of the formed particles requires …
-
Investigating permeation of anti-mycobacterial agents in Mycobacterium tuberculosis and M. tuberculosis-infected macrophages in vitro as a model for early stage tuberculosis drug discovery
… treatment duration, highlights the need for new effective treatments or strategies to shorten the treatment duration, improve patient adherence and curb the alarming rates of resistance. A key challenge to current strategies employed in the development of anti-TB drugs is the complexity in TB …