Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"bactericidal antibiotics"”.
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Generation of SOS inhibitors as co-drugs to potentiate the activity of bactericidal antibiotics and to block the emergence of antibiotic resistance
… accompanied with the small number of new antibiotics introduced in recent years, has limited the number of effective antimicrobials. The classical paradigm suggests that antibiotic resistance emerges by selection for pre-existing mutants in the bacterial population exposed to antibiotics. …
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Role of Bacterial Lipocalin Proteins in Antimicrobial Resistance
… upon exposure to<br/>sublethal concentrations of bactericidal antibiotics. BcnA captures a range of antibiotics outside bacterial cells, providing a global extracellular mechanism of antimicrobial resistance. In this thesis, I report that watersoluble<br/>and liposoluble forms of vitamin E inhibit …
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Testing oxidative-stress hypotheses generated by systems-biology assays
… of how YaaA does it remains unknown. Do antibiotics cause oxidative stress? Since 2007, several studies have reported that classic bactericidal antibiotics triggered the oxidation of an intracellular fluorescein probe, and this effect was attributed to hydroxyl radicals. Therefore, …
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Improving antibiotic activity by manipulating bacterial reactive oxygen species metabolism
The discovery of antibiotics was one of the most important medical breakthroughs of the twentieth century, having a broad impact on overall life expectancy and public health. Unfortunately, antibiotic discovery has slowed significantly in recent times and has failed to match the rising incidence of …
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Development of novel metal nanoparticle based methods for detection of bacteria using surface-enhanced Raman spectroscopy
The principal aim of this Ph.D. thesis was to develop new enhancing substrates for use in Surface-enhanced Raman Spectroscopy (SERS) for the rapid detection of live bacteria by analysis of the headspace above bacterial cultures. It is knownt hat in-situ SERS can be used to detect vapour phase …