Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 40 for “"bacterial vaginosis"”.
-
The effect of bacterial vaginosis on HIV infection
Human Immunodeficiency Virus-1 (HIV) and Bacterial Vaginosis (BV) are both among the most common diseases affecting young women in Sub-Saharan Africa. BV is characterised by dysbiosis in the female reproductive tract (FRT) when optimal Lactobacillus spp. such as L. crispatus, are displaced by …
-
The role of bacterial vaginosis-associated sialidase on HIV-1 infection
Studies suggest that women with Bacterial Vaginosis (BV) are at a higher risk of being infected by HIV-1. One possible reason is that bacterial vaginosis-associated bacteria (BVAB) release sialidases which alter either the virus and host cells directly or the viscosity of the female vaginal tract …
-
Investigate the effect of Bacterial Vaginosis-associated bacteria on the efficacy of Anti-HIV therapy
… spp. dominated population to one defined by bacterial vaginosis (BV) associated bacteria such as Gardnerella spp. not only increased the risk of HIV acquisition but also reduced the ability of ARVs to protect against infection. Additionally, Lactobacillus crispatus (L. crispatus) was used in …
-
Investigate the effect of Bacterial Vaginosis-associated bacteria on the efficacy of Anti-HIV therapy
… spp. dominated population to one defined by bacterial vaginosis (BV) associated bacteria such as Gardnerella spp. not only increased the risk of HIV acquisition but also reduced the ability of ARVs to protect against infection. Additionally, Lactobacillus crispatus (L. crispatus) was used in …
-
Cost-effectiveness of different screening and diagnostic strategies for sexually transmitted infections and bacterial vaginosis in women
… with sexually transmitted infections (STIs) and Bacterial Vaginosis (BV) is considered a key driver in the HIV/AIDS epidemic. A new rapid point-of-care (POC) test that detects genital inflammation in women was recently developed by researchers at the University of Cape Town. The objective of this …
-
Rapid point of care testing for sexually transmitted diseases and bacterial vaginosis: cost estimation and budget impact analysis
… a global public health concern. Together with bacterial vaginosis (BV), the association with HIV acquisition through genital inflammation in women poses a challenge towards the control of HIV/AIDS, more so in asymptomatic cases. Diagnosis of asymptomatic women using a genital inflammation …
-
Determinants of bacterial vaginosis (BV) in HIV negative women living in Cape Town, South Africa : a cross-sectional study
Bacterial vaginosis (BV) is a common cause of vaginal symptoms among women of childbearing age, although some women may be asymptomatic. The etiology of BV has been uncertain for many years, but several studies have related an increased frequency of BV to multiple diverse factors such as smoking, …
-
Diversity of vaginal microbiota associated with bacterial vaginosis and the impact on pregnancy outcomes in HIV-infected and uninfected women.
… spp. by anaerobic bacteria is known as bacterial vaginosis (BV). BV is prevalent in women of African descent and may be a cause of higher rates of adverse birth outcomes in these women. Adverse birth outcomes have been reported to be higher in HIV-infected women both on treatment or …
-
Evaluation of probiotic and vaginal Lactobacillus species for the treatment of bacterial vaginosis and promotion of vaginal health in South African women
Background: Bacterial vaginosis (BV) increases women's risk for adverse reproductive outcomes and acquisition of sexually transmitted infections (STIs), including HIV. The etiology of BV is still unclear, and it has been hypothesized that lytic or temperate Lactobacillus bacteriophages may …
-
Sexually transmitted infections, bacterial vaginosis and genital inflammation as risk factors of HIV acquisition in adolescent girls and young women in South Africa
… define the prevalence of sexual risk behaviour, bacterial vaginosis (BV), sexually transmitted infections (STIs), and genital fungal infections in South African AGYW; (2) to assess the relationship between symptoms and an etiological STI diagnosis; (3) to evaluate the influence of electronic and …
-
Characterization of the vaginal microflora
… microflora have discovered several uncultivated bacterial species. An important new insight which stems from our research efforts is the discovery that there is a strong association between bacterial vaginosis and the presence of a thus far unrecognized species, i.e. the strictly anaerobe and …
-
Characterisation of vaginal Prevotella strains from a cohort of South African adolescent girls and young women with and without bacterial women with and without bacterial vaginosis
A common condition in reproductive age women, bacterial vaginosis (BV), is characterised by a dysbiosis in the vaginal microbiome, and frequently associated with abundance of the genus Prevotella. Prevalence of BV is particularly high in sub-Saharan Africa and comprehensive characterisation of …
-
Assessment of Biomarkers of Intrauterine Inflammation Induced Preterm Labor
… effect in preventing the progression of bacterial vaginosis, in pregnant women. Bacterial vaginosis is the existence of infectious bacteria in the vagina. Normally, this mild infection in the vagina will disappear; however, in if it does not, bacterial vaginosis will progress to the …
-
Determination of factors affecting the community structure of Gardnerella spp. in the vaginal microbiome
Gardnerella spp. are a hallmark of bacterial vaginosis – a vaginal dysbiosis characterized by the shift from a lactobacilli dominated vaginal microbiome to a diverse microbiome composed of many aerobic and anerobic bacteria. Gardnerella spp. are diverse both phenotypically and genotypically and …
-
Optimal clustering techniques for metagenomic sequencing data
… made it possible to determine the composition of bacterial microbiota of the human body. Clustering algorithms have been used to search for core microbiota types in the vagina, but results have been inconsistent, possibly due to methodological differences. We performed an extensive comparison of …
-
Development of a multi-particulate formulation of viable bacteria for oral and vaginal delivery
… in the treatment of Crohn’s disease and bacterial vaginosis, respectively. The strategies used to stabilise lactic acid bacteria in solid dosage forms and the processing techniques used to manufacture the oral and vaginal dosage forms are also discussed in this introductory chapter.
-
Induction of metronidazole and clindamycin resistance in gardnerella vaginalis
Bacterial vaginosis (BV) is known to be the most common polymicrobial vaginal disorder in females of childbearing age. It is characterised by a change in the healthy vaginal microbiome, from an environment dominated by hydrogen-producing lactobacilli, to the overgrowth of opportunistic pathogenic …
-
A modular device for vaginal administration of multiple therapeutic agents
… (MET) is an antibiotic commonly used to treat bacterial vaginosis; and lactic acid (LA) and its cyclic dimer form lactide (LT) can maintain protective vaginal pH and provide an anti-inflammatory effect. Cores containing these drugs will be prepared using a thermosetting silicone elastomer …
-
The association between the oral and vaginal microbiome of young South African women
Bacterial vaginosis (BV) and periodontal disease (PD) are conditions characterised by reduction of healthy bacterial communities in the vaginal and oral microbiomes respectively. Both BV and PD are associated with an increased risk of preterm labour and negative birth outcomes, yet it is unknown …
-
Causal Inference Methods for Microbiome Data
… as key mediators linking sexual behavior to bacterial vaginosis (BV). Longitudinally, the joint mediation models captured hormonal and microbial pathways shaping community state type (CST) transitions, providing biologically interpretable insights into BV risk. In summary, this dissertation …
Page 1 of 2