Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"bacterial secretion"”.
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A Simulation Approach to the Study of Bacterial Secretion Proteins
… complex machinery associated with the type II secretion system (T2SS) polymerises inner membrane pseudopilin proteins into thin filaments, to export substrates such as toxins, hydrolases and cytochromes. Here, computational simulations were used to study proteins from the Klebsiella oxytoca …
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A study of SecA : the motor of the bacterial secretion system by site-directed spin labeling and EPR
… to SecA and ultimately driving it through the secretion pore.
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The Role of Galectin-3 in Pathogen Sensing and Cell Autonomous Defense
… for pathogens that reside within PVs are bacterial secretion systems. The bacterial secretion system is critical for the pathogen to be able to interact with the host environment, modulate cellular functions, and remodel the PV to facilitate growth. There is evidence that the host can …
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Specialised Effectors and Accessory Proteins Important in the Antibacterial Type VI Secretion System of <i>Serratia marcescens</i>
… utilised by Gram-negative bacteria is protein secretion, with bacterial secretion systems efficiently translocating particular proteins to the external medium or directly into competitor target cells. Recently, much progress has been made towards understanding the role and mechanism of the Type …
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Analysis of the diverse antibacterial strategies used by <i>Serratia marcescens</i> Db10
… this work, contact dependent and independent antibacterial strategies employed by <i>S. marcescens</i> Db10 are investigated at the molecular level.<br/><br/>Non-ribosomal peptide synthetases (NRPS) and polyketide synthases (PKS) are widespread in bacteria and fungi and are responsible for the …
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The Assembly of Pathogenic Signaling Circuits by a Family of Bacterial Secreted Effector Proteins
Bacterial type III secreted effector proteins facilitate Gram-negative bacterial replication, dissemination, and immune evasion in the infected host organism. While much attention has been focused on the cell inhibitory mechanisms of these virulence factors, there is emerging evidence that …
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A Systems Biology Approach to Study Type III and Type IV Bacterial Effector Properties
The interaction between Type III and Type IV bacterial effector proteins and host signal transduction enzymes is a critical interface that, in many cases, determines the outcome of infectious disease. While many pathogenic strategies, such as evasion of phagolysosomal fusion, have been identified …
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Characterization of Novel Type VI Effectors of Acidovorax citrulli and Their Applicability to Biological Control of Plant Diseases
Bacterial secretion systems have been playing essential roles in modulating the microbiota of most ecological niches. Among a variety of secretion systems, the Type VI Secretion System (T6SS), a nanomachine widely distributed in Gram-negative bacteria, is gaining increasing attention due to its …
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Analysis of Vibrio parahaemolyticus Virulence Systems
… including two hemolysins and two type III secretion systems (T3SS1 and T3SS2). Herein, we compare the virulence of V. parahaemolyticus POR strains, which harbor a mutation in the T3SS needle apparatus, to the V. parahaemolyticus CAB strains, which contain mutations in transcriptional …
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Structure & Function of Bacterial Transport Machines in their Cellular Context
… the host. Two such transporters in Gram-negative bacterial species are the MacA-MacB-TolC (MacAB-TolC) antibiotic efflux pump and the Type I Secretion System (T1SS), responsible respectively for antibiotic resistance and export of protein virulence factors. To pass the Gram-negative envelope in a …