Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"bacterial resistance"”.
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Bacterial resistance to chemotherapy
The last decade has witnessed an unprecedented development in the therapy of infectious diseases and a significant change in the practice of medicine. The variety of antibiotic substances discovered and made freely available during this short space of time permitted the ready control of many …
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Understanding Bacterial Resistance and Dissemination: The Impact of Biocide Priming
… may favour the prevalence of less susceptible bacterial strains and encourage the expression and dissemination of antibiotic resistance genes. Aims: To investigate the priming effects of sub-inhibitory concentrations of biocides on antibiotic resistance in bacteria and to understand the …
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The role of highly phosphorylated nucleotides in the development of bacterial resistance to antibiotics
… (HPNs; MSI, ppGpp; MSII, pppGpp) produced by bacterial cells during the late exponential and early stationary phases of growth, in response to adverse nutritional conditions. These compounds are involved in the phenomena of endosporulation and stringent response which both elicit an increase …
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The Design and Synthesis of Novel Antimicrobial Agents for Use in the Battle Against Bacterial Resistance
… 3 discusses the treatment of gram-negative bacterial infections with novel hybrid antimicrobial agents. These agents afford current antimicrobial agents, which have difficulty penetrating the gram-negative cell wall, a way into the gram-negative cell in order to exert their intended …
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High Resolution Mass Spectrometry (HRMS) Based Investigation of Small Molecule, Bioactive Secondary Metabolites as Probes in the Examination of Bacterial Resistance and Virulence
… pathogenic agents are exhibiting ever increasing resistance to many frontline antibiotics. New chemotherapeutic agents are urgently needed to combat this threat; this work seeks to illustrate applications in which mass spectrometric techniques may be applied to the investigation of novel, small …
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Demonstrating biocompatibility with supercritical CO₂ : biphasic cultivation of Bacillus spp. and probing acclimation mechanisms through proteome and lipid analysis
… aqueous phase incubated under scCO₂ (Chapter 2). Bacterial resistance to scCO₂ challenges the efficacy of scCO₂ based sterilization and indicates that microbial activity may be harnessed in engineered environments containing scCO₂ (e.g. biochemical catalysis involving scCO₂ as a solvent or …
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New Strategies for the Qualitative and Quantitative Analysis of Nitrofural and Its New Derivatives // Нови стратегии за качествения и количествен анализ на Nitrofural и неговите нови производни
… closely related to the ongoing manifestation of bacterial resistance. In this regard, the influence of Nitrofural polymorphism on the specific spectral (Infrared) behaviour of the semicarbazone C=O functional group was established. The existence of a metastable Nitrofural form has also been …
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Motif discovery in sequential data
… used by the innate immune system to combat bacterial infection in multicellular eukaryotes. There is mounting evidence that these peptides are less susceptible to bacterial resistance than traditional antibiotics and may form the basis for a novel class of therapeutics.
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A survey of antibiotic prescribing patterns and in-vitro antibiotic susceptibility patterns at the University Teaching Hosptal, Lusaka,Zambia ,1998
The development of drug resistance to common pathogens, has generated much concern in the medical community. The absence of an antibiotic policy at the University Teaching Hospital (UTH), has resulted in a high frequency of antibiotic prescription and probable inappropriate use. This may have …
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A survey of antibiotic prescribing patterns and in-vitro antibiotic susceptibility patterns at the University Teaching Hosptal, Lusaka,Zambia ,1998
The development of drug resistance to common pathogens, has generated much concern in the medical community. The absence of an antibiotic policy at the University Teaching Hospital (UTH), has resulted in a high frequency of antibiotic prescription and probable inappropriate use. This may have …
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Structural analyses of the ribosome by hybrid approach
… functions were investigated. First we studied bacterial resistance to the antibiotic tetracycline, a study that involved a detail investigation of processes in the ribosome. Second we employed MDFF and molecular dynamics simulations to characterize the dynamics of a ribosome-bound chaperone, …
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Remote asymmetric induction in the organocatalytic azaDarzens synthesis of peptide aziridines: towards the assembly of new glycopeptide antibiotic analogues
The widespread development of bacterial resistance to antibiotics is an ongoing process which represents a growing problem for modern medicine. Vancomycin is used as a drug of last resort against methicillin-resistant Staphylococcus aureus (MRSA), but the increasing prevalence of …
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DISCOVERY OF NOVEL MACROLIDE ANTIBIOTICS AND METHODOLOGY DEVELOPMENT OF N-SULFINYL METALLODIENAMINES
… of N-sulfinyl metallodienamines. To tackle bacterial resistance, new antibiotics are desperately needed. My research objective is to address this need by designing, synthesizing, and evaluating novel macrolide antibiotics based on the best-in-class drug candidate, solithromycin. The drug …
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Avaliação do uso de nano carreadores de ramnolipídeos associados ao fotossensibilizador azul de Taylor na terapia fotodinâmica antimicrobiana contra Staphylococcus aureus: estudo in vitro
The increase in bacterial resistance to antibiotics has driven the search for alternative therapies, such as Antimicrobial Photodynamic Therapy (PDT). With the advancement of science, nanotechnology techniques are increasingly present, promoting the enhancement of existing techniques. This study …
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Investigating the resistance that arises in Escherichia coli towards the furazolidone – vancomycin antibiotic combination : Master of Science (Biological Sciences) at Massey University, Manawatū, New Zealand
Antibiotic resistance is a major threat to our current healthcare system. As bacterial resistance mechanisms continue to develop and spread, more and more antibiotics are becoming less and less effective, making an increasing number of bacterial infections difficult or even impossible to treat. …
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Development of Computational Antibiotic Screening Platform Across Bacterial Outer Membrane Proteins
<p>Antibiotics are medicines used to treat bacterial infections by either killing bacteria or stopping them from reproducing. Throughout the use of antibiotics, bacteria has developed a variety of defense mechanisms against antibiotics and thus diminishing their effectiveness. Antibiotic resistance …
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Molecular methods for the detection of TEM- and SHV-related beta lactamase genes in members of the Enterobacteriaceae
Bacterial resistance to antibiotics is a common and important clinical problem. Beta lactam resistance in Gram negative bacilli is mediated predominantly by beta lactamases, enzymes able to hydrolyse the beta lactam ring. The commonest plasmid mediated beta lactamases in the Enterobacteriaceae are …
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Investigation of occurrence, elimination and degradation of pharmaceutical and personal care products in drinking water using liquid chromatography-tandem mass spectrometry
… the aquatic environment and cause development of bacterial resistance. In this research project, a comprehensive liquid chromatography tandem mass spectrometry method has been developed and validated for the analysis of sixteen pharmaceutical compounds using solid phase extraction. Treated and …
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Identification and Inhibition of Fosfomycin Resistance Enzymes for Structure-Based Drug Design
Antimicrobial resistance (AMR) is a pressing issue facing modern medicine today. Bacteria are developing resistance to antibiotics faster than new antibiotics can be brought to market. Antimicrobial resistant infections are responsible for increased morbidity and mortality rates, as well as an …
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Identification and bioactivity assessment of an antimicrobial peptide from the defensive skin secretion of the northern leopard frog, Rana pipiens
In response to the growing threat of bacterial resistance, antimicrobial peptides (AMPs) have emerged due to their broad-spectrum activity and low probability of resistance generation. In many ways, antimicrobial peptides have advantages that are difficult to match with antibiotics, and so research …
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