Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"bacterial pathogenesis"”.
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Chemical Reporters for Bacterial Pathogenesis and Beyond
… modifications to explore their functions in bacterial pathogenesis as well as basic biological pathways. Initially, I developed amino acid chemical reporters that allow the cell-selective labeling of bacterial proteomes to facilitate the analysis of bacterial protein expression during …
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Structural Investigation of Bacterial Pathogenesis and Host Immune Response
<p>Bacterial infection is a persistent threat to public health and agriculture. In nature, pathogenic bacteria utilize various mechanisms to invade the host and cause a variety of diseases in human, animals, and plants. Ongoing research is focused on revealing how several essential proteins …
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Targeting Virulence as an Approach to Bacterial Pathogenesis: Efforts Towards the Development of Chemical Biology Tools and Anti-Chlamydial Therapeutics
… the molecular underpinnings of C. trachomatis pathogenesis, as this microorganism has been historically refractory to genetic manipulation. Recent studies strongly suggest that the survival of C. trachomatis is dependent upon the secretion of a number of effector proteins and enzymes that …
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Characterization of Bacterial Metabolites Involved in Host Pathogen Resistance
… Although the abundance and diversity of bacterial metabolites in the intestine is appreciated, the majority of intestinal bacteria and bacterial products have not been characterized in the context of microbiota-mediated pathogen resistance. In this thesis, we describe two projects aimed …
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Molecular Basis of Corynebacterium Diphtheriae Virulence and Infection In The Caenorhabditis Elegans Model Host
… is certainly caused by diphtheria toxin, corynebacterial colonization may primarily require proteinaceous fibers called pili, which mediate adherence to specific tissues. The type strain of C. diphtheriae possesses three distinct pilus structures, namely the SpaA, SpaD, and SpaH-type pili, which …
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Identification and Characterization of Interferon-Stimulated Regulators of Bacterial Infection
… antiviral defense mechanism, yet its role in bacterial pathogenesis remains less well characterized. Using an intracellular pathogen Listeria monocytogenes as a model bacterial pathogen, I sought to identify the roles of individual interferon-stimulated genes in context of bacterial infection. …
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Trimming Fat Upon Infection: Proteolytic Demyristoylation as a Novel Bacterial Pathogenic Strategy
… infectious diseases. Shigella spp are food-borne bacterial pathogens and are one of the leading causes of bacterial dysentery worldwide. Similarly to other gram-negative pathogens, Shigella injects effector proteins into an infected cell to control its responses. Dedicated type III secretion …
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Assembly and Display of Surface Proteins In Actinomyces Oris
… plaques form as a result of up to 700 individual bacterial species colonizing oral surfaces and forming a multispecies biofilm. These biofilms are the cause of prevalent human diseases such as dental caries, gingivitis, and periodontitis. The microbes present in the oral biofilm are highly …
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Structural and Functional Characterization of B. Anthracis Udp-Glcnac 2-Epimerase and Salmonella Secreted Effector I
… an exceptionally powerful tool in the study of bacterial pathogenesis, not only in elucidating the molecular basis of disease as the first step towards the design of therapeutics but also in many cases leading to insights into hostpathogen biology that would not have been possible otherwise …
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Single-molecule visualization of conformational changes in the SecA ATPase
The need for new antibiotics is great as bacterial strains with single and multiple drug resistance have continued to grow more prevalent since the 1980's. At the same time, the rate of approval of new antibiotics has dropped precipitously. Existing antibiotics commonly target the bacterial …
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Computationally and Experimentally Exploring the Type IV Pilus Assembly ATPase for Antivirulence Drug Discovery
… factors that promote disease development. The bacterial type IV pilus (T4P) is a prevalent virulence factor in many ABR pathogens, contributing to bacterial pathogenesis by facilitating cell motility, surface adhesion, and biofilm formation. Critically, the T4P facilitates early stages of …
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A Structural Basis for Host Cytoskeletal Disruption and Virulence by Yersinia Protein Kinase A
… in probing the function and mechanism of YpkA in bacterial pathogenesis, but also are potential candidates for further development of novel anti-plague drugs.</p>
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Investigating the Role of Trimeric Autotransporter Adhesins in Fusobacterium nucleatum Pathogenesis
… historically known for their contributions to bacterial pathogenesis. This dissertation encompasses the use of recombinant protein expression systems and newly developed gene deletion technology to provide a foundational understanding of the contribution of Type 5c secreted proteins in F. …
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Role of Occludin in the Regulation of Epithelial Tight Junctions
… a disruption of which is involved in the pathogenesis of many gastrointestinal, pulmonary and renal diseases. Occludin is the major transmembrane protein of TJ, a deletion of which leads to a complex phenotype including chronic inflammation in several epithelial tissues of occludin …
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Biological Consequences of Atypical Phage Conversion in Gram-Positive Pathogens
… between host and phage with important impacts on bacterial pathogenesis. This Thesis explores some of these lesser-studied phage-bacteria interactions, describing atypical mechanisms ("conversion events") by which phage shape the populations of Bacillus anthracis and Staphylococcus aureus, driving …
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Characterization of novel virulence factors of Shigella flexneri and development of Caenorhabditis elegans as an animal model for Shigella infection
… vaccine is ongoing. A thorough understanding of bacterial pathogenesis is paramount for the development of an effective vaccine. To this end the aim of this thesis is to further our understanding of S. flexneri pathogenesis by characterizing novel virulence factors and to develop a new animal …
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Characterization of novel virulence factors of Shigella flexneri and development of Caenorhabditis elegans as an animal model for Shigella infection
… vaccine is ongoing. A thorough understanding of bacterial pathogenesis is paramount for the development of an effective vaccine. To this end the aim of this thesis is to further our understanding of S. flexneri pathogenesis by characterizing novel virulence factors and to develop a new animal …
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Evolution and phenotypic diversification in serratia marcescens biofilms
… of phenotypic diversification during bacterial pathogenesis and bacterial persistence. Characterization of the microcolony biofilm development of S. marcescens revealed that the S. marcescens biofilm develops through a process involving microcolony formation, hollowing of mature …
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Natural Genetic Variants in Humans and Salmonellae Underlie Variable Infection Outcomes
… secretions systems (T3SS), which inject bacterial proteins called effectors into host cells. These effectors create a hospitable niche inside host cells for the replicating bacteria. Outside of the core genome, each serovar carries hundreds to thousands of different genes, which means …
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Studies on the architecture and on transferability of pathogenicity islands of uropathogenic Escherichia coli strain 536
… including the sequence determination of complete bacterial genomes started a new era in microbiological research. Since then more than two hundred prokaryotic and eukaryotic genomes have been completely sequenced, and there are additional complete genome projects including different bacterial …
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