Global ETD Search
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Showing 1 to 3 of 3 for “"bacterial multidrug efflux"”.
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Molecular recognition, in- and out- of equilibrium, in the actions of bacterial multidrug efflux nanomachines
… infections is outpacing the provision of new antibacterial treatments and leading to a growing health and economic burden. One of the main mechanisms that bacteria use to acquire drug resistance is through the expression of multidrug efflux transporters. Among the many efflux pumps present in …
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Investigations into the Lipid Transport Mechanisms and Energetics of Bacterial ATP-Binding Cassette (ABC) Transporters MsbA and LmrA
LmrA and MsbA are two paradigms in research on multidrug ATP-binding cassette (ABC) transporters. The bacterial transmembrane protein LmrA from *Lactococcus lactis* was the first known prokaryotic ABC transporter homologue of the mammalian multidrug resistance transporter ABCB1 (P-glycoprotein) …
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Characterization and Inhibition of the Dimer Interface in Bacterial Small Multidrug Resistance Proteins
… cytotoxic molecules from the cell. The small multidrug resistance protein family (SMR) is one such group of drug transporters that because of their relative small size [ca. 110 residues with four transmembrane (TM) helices] must form at the minimum dimers to efflux drugs. We have used the SMR …