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Showing 1 to 20 of 21 for “"bacterial metabolism"”.
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Integrated modeling of bacterial metabolism
Cell metabolism is an extraordinary complex process that involves coordinated operation of multiple cellular processes. The overwhelmingly complexity due to the interconnected nature poses a grand challenge for systems biologists to achieve a system-level understanding of bacterial metabolism. …
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Antibiotic Drug Discovery Targeting Bacterial Metabolism
… it possible. In recent years, however, emerging bacterial resistance to virtually all major antibiotic classes has resulted in a worldwide increase in morbidity, mortality, and financial burden associated with drug resistant infections. The antimicrobial resistance crisis presents an urgent need …
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Effects of Low Concentrations of Chloramphenicol on Bacterial Metabolism
Made available in DSpace on 2014-12-10T23:24:33Z (GMT). No. of bitstreams: 1 7414534.pdf: 7814477 bytes, checksum: 7a9297e97512cdcfc242e904002670ad (MD5) Previous issue date: 1974
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The role of metabolism in the pathogenesis of adherent invasive Escherichia coli (AIEC)
… by HM605 is independent of intracellular bacterial replication, it is dependent on an active bacterial metabolism. Through the establishment of a genetic screen aimed at identifying mutants which activate the inflammasome to lower levels than the wild-type, we confirm our observation that …
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Pharmacological studies of C. elegans cultured in axenic media: nicotine and its effects on growth, body morphology, and reproduction
… culture method for raising C. elegans is to use bacterial Escherichia coli media plates. Using bacterial media can be resource intensive, result in turbidity for microscopy based assays, and bacterial metabolism can affect any pharmaceuticals introduced to the system. Liquid axenic media is …
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Integration of metabolic modelling with machine learning to identify mechanisms underlying antibiotic killing
… of how these antibiotics interact with cellular metabolism. Evidence is increasingly building that the efficacy of antibiotics relies critically on downstream metabolic effects, in addition to inhibition of primary targets. Here we present a novel computational pipeline to expedite investigation …
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Construction of a Pseudomonas aeruginosa Dihydroorotase Mutant and the Discovery of a Novel Link between Pyrimidine Biosynthetic Intermediates and the Ability to Produce Virulence Factors
… as well as cell wall synthesis and the metabolism of certain carbohydrates. Recent findings, however, indicate that the pyrimidine biosynthetic pathway and its intermediates maybe more important for bacterial metabolism than originally thought. Maksimova et al., 1994, reported that a P. …
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Monitoring, characterizing, and preventing microbial degradation of ignitable liquids on soil
… can also serve as a source of carbon to support bacterial growth. This is problematic for fire debris analysis as samples may be stored at room temperature for extended periods before they are analyzed due to case backlog. As a result, selective loss of key components due to bacterial metabolism …
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Effects of Brassica on the human gut microbiota
… the composition of the gut microbiota, and the bacterial mechanisms employed for glucosinolate metabolism, are unclear, and forms the basis of the research presented in this thesis. Culturing human faecal microbiotas in an in vitro batch fermentation model identified the bacterial-mediated …
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Improving antibiotic activity by manipulating bacterial reactive oxygen species metabolism
… and nucleic acids, and can ultimately result in bacterial cell death. The body of work described here shows that this common mechanism can be exploited to improve antibiotic activity, regardless of the antibiotic's primary mode of action. First, I will describe how bacterial metabolism can be …
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Accelerated Ripening of Reduced-Fat Cheddar Cheese from Condensed Milk
… and lactic acid continues to develop from bacterial metabolism. The mats are then milled ( cut into small pieces, approximately 5 cm x 1.5 cm x 1.5 cm), salted, and pressed together in forms (hoops). The pressed cheese is aged for 2 to 12 months at 4 to 8°C to develop a smooth texture, with …
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Biotin synthesis in Bacillus subtilis
… the source of pimelic acid is unknown in bacterial metabolism. My results show bioW is essential for biotin synthesis whereas bioI is dispensable. I uncovered a unique function of BioW as a proofreading enzyme of noncognate acyl-adenylate substrates other than pimeloyl-adenylate to ensure …
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Effects Of Environmental Factors On Anaerobic Granular Sludge In Upflow Anaerobic Sludge Blanket Reactors
… sufficient amount of these elements for the bacterial metabolism, and excellent COD digestion rates could be maintained in the reactors. Yeast extract showed a strong positive effect on the bacterial growth rate, but had no significant contribution to the specific activity of bacteria.;The …
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The bacterial synthesis and characterisation of polyhydroxyalkanoates using waste plastics as carbon sources for novel applications
… high costs of the carbon sources required for bacterial metabolism and the chemical processing required to extract stable, contaminant-free PHA structures from biomass, that are comparable to the wide range of petrochemical plastics currently in use. This study has considered the novel use of …
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The Role of Lysogenic Bacteriophage in Virulence and Survival of Streptococcus Pyogenes
… either within the host cell or within the bacterial population. In turn, we also hoped to determine how the bacteria (and possibly other integrated phage) might influence prophage activity or gene expression. Our studies focused on two polylysogenized GrAS strains, a M6 serotype (MGAS10394) …
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Activation of proestrogens from hops by human intestinal bacteria: conversion of isoxanthohumol into the potent phytoestrogen 8-prenylnaringenin
… and related with variable intestinal bacterial metabolism, the goal of this work was to investigate whether intestinal bacteria also determine the final activity of hop phytoestrogens by combining batch incubations with SHIME, rat and human studies. Batch incubations learned that 8-PN …
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Development of Steady-State and Dynamic Flux Models for Broad-Scope Microbial Metabolism Analysis
… examining cell flux distributions in the central metabolism. FBA, on the other hand, gives a holistic review of optimal fluxomes on the genome scale. In this dissertation, flux analysis techniques were constructed to investigate the microbial metabolisms.</p> <p>First, an open-source and …
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Learning the ABC's of Ribose Transport Using Biophysical Methods
… in a variety of biological phenomenon, from bacterial metabolism to cellular homeostasis, antigen-presentation, and drug resistance. These proteins are implicated in a variety of clinically relevant phenomenon, including the human diseases cystic fibrosis, macular degeneration, and cancer. …
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Non-Canonical Axonal Insulin Receptor Signaling Drives Aversive Olfactory Learning
… chemical butanone is a common product of bacterial metabolism, and therefore a bacterial odor that is attractive to worms. However, exposing C. elegans to butanone vapor while depriving them of food can suppress this attraction. C. elegans senses butanone with its AWCON neuron, and the …
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Interplay Between Tryptophan Metabolites and the Virulence Factors of Enteric Pathogens
… Small molecules derived from diet, gut microbial metabolism, and host metabolic activity have an impact on dictating the underlying gut microbiome composition. Gut bacterial populations effectively sense these molecular signatures and modulate gene expression to colonize this niche. An invading …
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