Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"bacterial invasion"”.
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Higher-order interaction inhibits bacterial invasion of a phototroph-predator microbial community
… be important for determining its resistance to invasion. Studies of natural ecosystems, from plant to microbial communities, have found that more diverse communities are more resistant to invasion. It is thought that more diverse communities resist invasion by more completely consuming the …
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Toll like Receptor 4-Mediated Immune Responses in the Bladder Epithelium
… immune responses. TLR4 recognizes Gram-negative bacterial component LPS and initiates a series of intracellular NF-kappaB associated signaling events resulting in a cytokine response. We examined intracellular signaling events in human BECs leading to the production of IL-6, a major urinary …
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Epithelial Cell Autophagy in Antibacterial Defense of the Small Intestine
… responses play an essential role in preventing bacterial invasion of host tissues and maintaining a symbiotic host-bacterial relationship. Autophagy is emerging as an important component of innate immunity. Mounting evidence suggests that dysregulation of the autophagy-independent function of …
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Molecular Mechanisms Involved in Escherichia coli K1 and Haemophilus influenzae Type a Blood-Brain Barrier Impairment
… which they share a common basement membrane. Bacterial meningitis is a common and severe Central Nervous System (CNS) infection, caused by different pathogens, including Escherichia coli K1 (E. coli K1) and Haemophilus influenzae type a (Hia). During E. coli K1 meningitis, CNS cells release …
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An Attempt to Develop Resistance in the Udder Against Streptococcus Dysgalactiae and Escherichia Coli
… with an antigen and produce an immunity to bacterial invasion. Thus this investigation deals with an attempt to immunize cow’s udders with Streptococcus dysgalactiae and Escherichia coli.</p>
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The Selective Action of Certain Volatile Oils in the Destruction of Bacteria
… power of these oils to protect the plant against bacterial invasion, the germicidal powers of quite a number were accurately determined. Regularly used chemical germicidal agents are known to differ in their power to kill bacteria; for instance, phenol kills more readily than alcohol. Some …
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Antibacterial peptides - key players in host defense at epithelial surfaces
… at epithelial surfaces are important to prevent bacterial invasion. Streptococcus pyogenes, group A streptococcus (GAS), has an affinity for epithelial cells and cause pharyngitis. During streptococcal pharyngitis, high concentrations of the chemokines CXCL9/MIG, CXCL10/IP-10, CXCL11/I-TAC were …
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Novel Functions of ATG16L1 in the Innate Response to Invasive Bacterial Pathogens
… and NOD2, which are intracellular sensors of bacterial invasion. Secondly, we identified an interaction between complement C3, the central component of the complement cascade, and ATG16L1. This interaction allows for efficient targeting of complement C3-coated invasive pathogens to the …
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CARATTERIZZAZIONE IN VITRO DELLA RISPOSTA A STIMOLI INFETTIVI DELLE CELLULE EPITELIALI MAMMARIE BOVINE (BME-UV)
… plays a major role in defending the udder from bacterial invasion. Moreover, recent investigations suggest that mammary gland epithelial cells could have a large and important role as a source of soluble components of immune defenses. An experimental model was developed based on BME-UV cell …
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Growth outcomes of Pseudomonas aeruginosa inhibitor of vertebrate lysozyme knockouts in conditions mimicking the cystic fibrosis lung environment
… strategy towards defending against the bacterial invasion of PA<em> </em>is by the antibacterial activity of our own innate immune system with use of elements such as lysozyme. <em>Pseudomonas aeruginosa </em>inhibitor of vertebrate lysozyme class 1 (Ivyp1) is a periplasmic protein …
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Sphingomyelin as a danger signal in cell-autonomous immunity
… immunity to defend their cytosol against bacterial invasion. One such mechanism involves indirect detection of the pathogen through recognition of pathogen-induced disturbances causing the appearance of specific host molecules in an abnormal location. For example, glycans, which are …
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Effector-driven actin reorganisation restricts Salmonella invasion.
… Whereas the role of SopE in promoting bacterial uptake is well-established, the precise function of SopE2 is not known. SopE2 was previously shown to activate Cdc42, which leads to the mobilisation of N-WASP and the resulting Arp2/3 complex-mediated actin assembly. This work establishes …
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Interactions of Chitin and Lignin Thin Films with Other Molecules
… family 18 chitinases are vital for understanding bacterial invasion of fungi and human defense against fungal infection. Regenerated chitin (RChitin) thin films were prepared via chemical conversion and spin-coating. Changes in their mass and viscoelasticity were monitored by a QCM-D in real time …
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Structural and functional studies of type three secretion virulence factors from gram-negative pathogenic bacteria
… of both of these species involves the invasion of epithelial cells of the gastrointestinal tract, which requires the use of a type III secretion system (TTSS). The Shigella type III secretion apparatus (TTSA) is composed of a basal body spanning both bacterial membranes and an exposed …
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Haemophilus influenzae adhesins and the innate immune response
… surface fibrils (Hsf) may increase the bacterial survival by interacting with vitronectin in serum. We also describe the isolation and characterization of a novel H. influenzae adhesin designated protein E (PE). PE was isolated by using an IgD myeloma serum which specifically recognized …
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Analysis of Small Molecule Inhibitors Aimed at Bacterial Virulence
<p>The emergence of antibiotic-resistant bacterial pathogens and the discovery of new bacterial pathogens have motivated the development of novel antibacterials. One recently proposed strategy is to target pathogenic bacteria specifically by inhibiting virulence mechanisms as opposed to killing …
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The intrinsic role of SOCS1 in intestinal epithelial cells
… stress response. Ensuing dysbiosis and bacteria invasion would then trigger immune responses for bacteria killing, whereas erosion of the colon epithelium in colitis Socs1ΔIEC mice seems driven by STAT1-dependent sensitization of Socs1- null IECs to apoptosis induced by immune cells-derived IFNγ …
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Protein mis-folding and human disease
… addition, research was carried out on the bacterial protein Burkholderia invasion<br/>protein D (BipD). BipD (33kDa) belongs to type III secretion system of Burkholderia<br/>pseudomallei. It creates a pore in the host cell membrane to help the B.<br/>pseudomallei invasion. This bacterial …
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Gene expression during the host-bacteria interaction
… outcome. While the transcriptional response to bacterial infection is well studied, the analysis of gene expression is incomplete without also looking at translation. Translation regulation allows for a more rapid and dynamic response than transcriptional regulation and it is well characterized …
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The role of IFN-γ in cell-autonomous immune responses against Salmonella Typhimurium and Toxoplasma gondii
… presentation and enhances antiviral and antibacterial immunity. In the case of bacterial pathogens, such as S.Typhimurium, priming with IFN-γ leads to an inflammatory but controlled cell death mechanism known as pyroptosis, following bacterial invasion of the cytosol or experimental …
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