Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"bacterial immunity"”.
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Conflict between bacteriophages and a mobile genetic element in bacterial immunity
Bacteriophages (phages) are the most abundant biological entities on the planet. They are ubiquitous and numerous across the many environments bacteria are found. To combat phage predation, bacteria have evolved numerous immune strategies, so-called anti-phage defense systems. Likewise, phages …
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Mechanisms of phage detection by bacterial innate immune proteins
… through killing infected cells to protect the bacterial population, they must stay inactive prior to infection, but rapidly detect phages and promptly trigger an immune response. Although many novel Abi systems have been discovered in recent years, how they detect phage infection remains poorly …
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Functional Organization of Molecular Memories in the CRISPR-Cas Immune System
… systems endow bacteria and archaea with adaptive immunity against foreign genetic threats, like phages and plasmids. These immune systems are comprised of CRISPR-associated (Cas) protein effectors and DNA-based storage of immunological memories in the CRISPR array. The CRISPR array is a series of …
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Recombination and Excision: DNA Repair Proteins in Prokaryotic Host-Virus Conflicts
… for Red-like recombination systems in countering bacterial immunity, through the protection of phages against sequence-specific nucleases. Based on these findings, I speculate that the counter-immune advantage imparted by Red-like systems may facilitate their spread across bacteriophage genomes. …
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Molecular Mechanisms of Sensing and Synergy by Anti-Bacteriophage Immune Systems in Staphylococcus
… encoded systems to defend themselves. Immunity can be conceptualized as occurring in three fundamental stages. First, the immune system must identify an invading pathogen— either directly via recognition of a pathogen-associated molecular pattern (PAMP), or indirectly by sensing the …
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Restriction-Modification and CRISPR-Cas Systems: Cooperation Between Innate and Adaptive Immunity in Prokaryotes
… may interact with each other in the context of immunity during bacteriophage infection is poorly understood. Here, in my thesis work, I investigate the interplay between RM and type II-A CRISPR-Cas systems. First, I demonstrate that RM systems provide a weak and temporary protection that …