Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"bacterial genes"”.
-
Bacterial genes and genome dynamics in the environment
… or gene expression evolution. Associating genes' usage and evolution to adaptation in various environments is a cornerstone of microbiology. New technologies and approaches have revolutionized this pursuit, and I begin by describing the computational challenges I resolved in order to bring …
-
The Sequence Landscape of Bacterial Genes is Shaped by Long-Range mRNA Folding
… evolutionary selection for optimal expression of genes in regulatory networks has led to discernable sequence patterns in bacterial genomes observed in nature. Such patterns result from gene regulatory strategies that leverage sequence-dependent interactions with key cellular machineries and …
-
Identification and characterisation of bacterial genes associated with resistance to and/or degradation of environmental pollutants
… Polycyclic Aromatic Hydrocarbons (PAHs). Alcaligenes sp. AO22 and Arthrobacter sp. E9 were identified from the lead contaminated site, while Stenotrophomonas maltophilia was identified from the PAH contaminated site. Minimum Inhibitory Concentration assays (MICs) were previously performed on …
-
Applicability of vaccinia virus as cloning and expression vector for bacterial genes: mice immune responses to vaccinia virus expressing Brucella abortus and Listeria monocytogenes antigens
… reasons for this phenomenon, by using other genes/proteins from BA and Listeria monocytogenes (LM), various shuttle plasmids (pSC65, pSC11) and immune response modulators (CpG, IL-12, B7-1). As the first objective, a vaccinia virus recombinant (WRL7/L12), expressing the BA L7/L12 gene was …
-
Unearthing the mechanisms of the mycorrhizal-bacterial symbiosis in plant roots using a metatranscriptomic approach
… and functional characterization of these bacterial endosymbionts has been limited by an inability to isolate and culture such obligate symbionts, which have significant metabolic dependencies on the host fungi. In this work, a metatranscriptomic approach is applied in order to determine …
-
Genome-Scale Quantification of Target Vulnerability in Mycobacterium Tuberculosis
<p>Essential bacterial genes orchestrate core biological processes and represent the targets of nearly all antibacterial drugs. Traditional genetic approaches such as knockout studies and transposon mutagenesis have cataloged hundreds of essential bacterial genes but provide no basis on which to …
-
Identification of bacterial pathogenic gene classes subject to diversifying selection
Availability of genome sequences for numerous bacterial species comprising of different bacterial strains allows elucidation of species and strain specific adaptations that facilitate their survival in widely fluctuating micro-environments and enhance their pathogenic potential. Different bacterial …
-
Differential Screening in Immunodeficient Mice Reveals Bacterial Enzymes With Unexpected Roles in Host-Pathogen Interactions
… and Salmonella typhimurium. In order to identify bacterial genes that provide protection against specific host immune pathways, we have developed the strategy of "differential" signature-tagged transposon mutagenesis (STM). By evaluating bacterial mutants for differential virulence in strains of …
-
Control of Shigella sonnei and adhesive invasive Escherichia coli infections with a natural product which inhibits the bacterial oxidoreductase DsbA
Many Gram-negative bacterial pathogens such as Shigella and adhesive invasive Escherichia coli (AIEC) cause infections characteristic of hyperinflammation. These infections require antimicrobial therapy. However, due to the widespread emergence of multiple drug-resistant strains, alternative …
-
The role of CLE peptides during nodulation
… the spatio-temporal expression of plant and bacterial genes. Nodulation can be divided in two developmental pathways, bacterial infection and organ initiation, and the two merge when the bacteria are taken up by the plant cells. Two types of nodules have been characterized, determinate …
-
Understanding polycyclic aromatic hydrocarbon degradation by soil microbial communites: the concentration and distribution of aromatic dioxygenase genes
… ability to individually identify and enumerate bacterial genes in the environment is an important development in the field of microbial ecology. Researchers are now able to quantify and map populations and communities, the presence of which could only be inferred until recently. Knowledge of …
-
Investigation of Pantoea stewartii Quorum-Sensing Controlled Regulators and Genes Important for Infection of Corn
… into the interactions occurring between this bacterial pathogen and its plant host may lead to informed intervention strategies. This phytopathogen uses quorum sensing (QS) to coordinate cell density-dependent gene expression and successfully colonize corn leading to wilt disease. Prior to the …
-
Discovering the Biological Activities of Maltose Derivatives for Controlling Bacterial Multicellular Behaviors
… can relay the modified antibiotic resistant genes to other bacteria and other species through a process called conjugation. Thirdly, bacteria quickly give up their individuality to become a part of a team to form surface attached multicellular communities known as biofilms. Bacteria residing …
-
Exploring the Role of Wolbachia Endobacteria in the Biology of Filarial Nematode Parasites
… reductive evolution could have removed redundant genes or pathways present in both partners. Thus, deletions in the worm's genome would render it dependent on <italic>Wolbachia</italic> for vital gene products. Conversely, <italic>Wolbachia</italic>-dependent species could re-acquire vital genes …
-
Investigating the Influence of Fresh and Aged Garlic Extracts on the Biosynthesis of Trimethylamine N-Oxide
… shifts in the abundances of gastrointestinal bacterial genes that may contribute to reduction in circulating TMA levels, which may, in turn, influence the levels of circulating TMAO. Methods: Five-week old female C57BL/6 mice (n = 12) were challenged with L-carnitine to assess the animal's …
-
The functional role of root-associated microbiome and metabolome of myrothamnus flabellifolia
… Metagenomic analysis unveiled prevalent bacterial phyla (Acidobacteriota, Actinobacteriota, Chloroflexota, Planctomycetota, and Pseudomonadota) and dominant fungal phyla (Ascomycota and Basidiomycota) across all zones. While the bulk soil hosted numerous beneficial root-associated …
-
Investigation of plant protein functionality for food applications and health benefits
… using pooled faecal samples over 24 hours. Bacterial enumeration and 16s rRNA gene sequencing revealed a significant increase in lactic acid bacteria, Bacteroides, and Bifidobacterium levels during fermentation. Short-chain fatty acid (SCFA) analysis showed a significant increase in acetic …
-
Analysis of TpeL secretion in Clostridium perfringens
… an experimental plan to characterize the genes involved in muscle cell adherence as a very basic model to mimic skeletal muscle attachment in gas gangrene. Like many other bacteria, C. perfringens can produce T4P, extracellular filaments that are synthesized, extended and retracted from …
-
Estudio de genómica comparada de genes bacterianos relacionados con la proliferación en la rizosfera
… colonization of the rhizosphere, as well as the genes involved in the different stages of colonization. The RpoN and FliA genes have been described as genes involved in biosynthesis, the RelA gene is related to stress adaptation and the GalU gene is described as involved in the later stages of …
-
A Study of the Genetics of Root Nodulation in Pigeonpea (Cajanus cajan) Using Indigenous Rhizobia
… strains derived from pigeonpea, two housekeeping bacterial genes (namely 16S rRNA and recA) were used to identify each rhizobial strain to the species level. In addition, the phylogenetic relationships among these rhizobial strains were determined. The results showed that 56 strains were confirmed …