Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"bacterial fitness"”.
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Genome-Scale Quantification of Target Vulnerability in Mycobacterium Tuberculosis
<p>Essential bacterial genes orchestrate core biological processes and represent the targets of nearly all antibacterial drugs. Traditional genetic approaches such as knockout studies and transposon mutagenesis have cataloged hundreds of essential bacterial genes but provide no basis on which to …
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The role of cooperation and dispersal in the evolution of antibiotic resistance
… to the natural selection, phenotypes with higher fitness than the rest of the population increase in frequency and eventually dominate the populations. In real biological systems due to interactions between individuals within a population, it is not always obvious how natural selection manifests …
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The contribution of competence system to the virulence of Streptococcus pneumoniae
… for the degradation of (NETs, virulence and bacterial dissemination. In addition, my data demonstrate that EndA molecules are secreted into the environment, and secreted EndA contributes substantially to “constitutive state” nucleolytic activity. Finally, the nuclease inhibitor …
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Engineering Tumor-Targeting Bacteria and Characterizing Their Interactions with Tumor Cells in Therapy-Resistant Breast Cancers
… collagen disruption, but at the cost of reduced bacterial fitness and motility. In this dissertation, we hypothesized that a fitness-restored, ECM-targeting ST enhances bacterial intratumoral transport and colonization, as well as chemotherapy penetration. We evaluated the engineered strains in …
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Studies into Transcriptional Pausing Regulators and Drug Resistance in Mycobacterium Tuberculosis
… to characterize later steps of the Mycobacterial transcription cycle. We aim to shed light on vulnerabilities within the cycle that may be targeted by therapeutics. We are therefore studying RNA polymerase (RNAP), the central enzyme of transcription, and associated transcription factors. …
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Impatto di rifaximina sul microbiota intestinale: selezione di bifidobatteri antibiotico resistenti
… absorption while retaining good antibacterial activity. Both experimental and clinical pharmacology clearly show that this compound is a non systemic antibiotic with a broad spectrum of antibacterial action, covering Gram-positive and Gram-negative organisms, both aerobes and …