Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"bacterial challenge"”.
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Bacterial Challenge in Lumbricus Terrestris: A Terrestrial Invertebrate Immunotoxicity Model.
A bacterial challenge assay was developed utilizing the earthworm, Lumbricus terrestris, in order to assess potential immunotoxic effects from exposure to specific polychlorinated biphenyl congeners. Earthworms were inoculated with Aeromonous hydrophila, establishing a 10-day LD50. In vitro assays …
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Study of phenotypic and gene expression response to bacterial challenge
… and gene-expression responses to the original challenge. Studies of the phenotypic response to BCG involves several behavior indicators, categorized as representing an initial period of sickness response, and a set of depression-like behaviors that can endure for several weeks. Little is known …
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Influence of copper on resistance of Lumbricus terrestris to bacterial challenge
Earthworms, Lumbricus terrestris, were challenged orally and intracoelomically with two bacterial species, Aeromonas hydrophila and Pseudomonas aeruginosa, and mortality rates were observed. Neither were found to be particularly pathogenic at injected doses of up to 108 bacteria per earthworm. The …
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Immunodulation of inflammation in a murine pnemococcal sepsis model
… at different time points (6h, 12h and 24h) after bacterial challenge for bacteriological examinations, serum cytokine measurements, and biochemical assays for liver function. Spleens were harvested for flow cytometric analysis of splenic lymphocytes or NK activation. Innate stimulation with LPS …
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Integrating mathematical models with experimental data from in vivo studies to investigate the within-host dynamics of Salmonella Typhimurium
Bacterial diseases have historically accounted for a high burden of morbidity and mortality worldwide. While antibiotic therapy and immunisations have significantly improved clinical outcomes in the last couple of centuries, the rate at which new treatments and vaccines are being developed has …
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A proteomic investigation of the immune response of the South African abalone, Haliotis midae
… changes in response to Vibrio anguillarum challenge. A preliminary iTRAQ challenge trial was conducted which identified a putative early (1 and 2 hours post-injection) and late (48 hours post-injection) proteome response to bacterial-challenge. Using these time points, four independent …
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Characterisation of a novel leukocyte receptor complex-encoded receptor TARM1
… sites. Following ip LPS treatment or systemic bacterial challenge, TARM1 protein expression was upregulated by myelocytes, mature neutrophils and inflammatory monocytes and TARM1+ cells were rapidly recruited to sites of inflammation. TARM1 expression was also upregulated by bone marrow–derived …
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House Fly (Musca Domestica L.) Temporal and Spatial Immune Response to Streptococcus Pyogenes and Salmonella Typhimurium: Role of Pathogen Density in Bacterial Fate, Persistence and Transmission
… Cecropin and Diptericin were investigated. Both bacterial dose and species affected survivability of these pathogens in the house fly alimentary canal. High dose of both species survived throughout the 24 h period. The number of viable S. typhimurium increased in 2 numbers in both high and low …
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Use of transgenic mice to study the role of autophagy protein ATG16L1 in Crohn’s Disease
… cellular degradation pathway also linked to bacterial defence2. It is not known how disruptions in ATG16L1 or autophagy contribute to CD pathogenesis, although evidence increasingly suggests their involvement in defective defence against bacterial infections. We hypothesise that autophagy …
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Mild traumatic brain injury augments innate immune responses through neurokinin and cholinergic signaling
… patients. Using our mild TBI model followed by bacterial pneumonia, we investigated the effect of neuronal signaling on innate immune function. To test whether any mild injury primes host immune responses to pneumonia, we generated a mild tail trauma (TT) model. mTBI mice showed protection from …
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Acyloxyacyl Hydrolase: Studies on Its Regulation and Function in Mus Musculus
… is an enzyme that detoxifies Gram-negative bacterial lipopolysaccharides (LPS) by selectively removing secondary acyl chains from the lipid A moiety. Originally found in neutrophils, it is also produced by monocyte-macrophages and renal proximal tubule cells. In the studies described here, I …
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Investigating the effect of yeast and mineral dietary supplements during the periparturient period on the production, physical health, and innate immune system of dairy cows
… the in vitro innate immune cell reactions to a bacterial challenge in whole blood collected from cows on either study. An analysis of the variation in total ration composition indicated that experience of the feeder may play a role in reducing the error of loading individual ingredients used to …
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The Effect of Electroshock on the Passage of Bacteria From a Contaminated Transducer Past a Protective Membrane into a Disposable Chamber Dome
… be contaminated transducer heads and no mode of bacterial transmission was identified. It appeared that transmission occurred at the transducer-dome junction.</p> <p>In an attempt to identify whether electroshock, such as a patient might undergo during cardiac defibrillation, could allow …
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An In-Vitro Comparison of Microleakage With E. faecalis In Teeth With Root-End Fillings of Proroot MTA and Brasseler's EndoSequence Root Repair Putty
… biocompatible, hydrophilic, radiopaque, and antibacterial due to a high pH during setting. Investigations on the sealing properties of this material have not yet been conducted. The purpose of this study was to compare the microbial leakage of Enterococcus faecalis in teeth with root-end fillings …
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The damaged mucosal barrier in intestinal inflammation: interaction with therapeutic bacteria and roles for metallothioneins as immunomodulators
… defects in the interaction of the host with the bacterial flora. The epithelium must maintain a physical barrier between the lumen and the underlying mucosa. Defects in the mucus layer, integrity, and permeability are found in IBD and are thought to have direct implications on disease initiation …