Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"bacterial cell wall"”.
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On the Gram-positive bacterial cell wall.
Cell wall is the outermost part of Gram-positive bacteria. It is intricately tied to the bacteria's response to environmental stimuli and challenges, and its makeup dynamically changes as a part of bacterial adaptation. Peptidoglycan is the biopolymer that composes nearly half of the cell wall, and …
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Metabolomic Analysis of Bacterial Cell Wall Intermediates Using LC-MS/MS: Peptidoglycan Pathway Response to Different Antibiotics
The bacterial cell wall is made up of peptidoglycan (PG) and its synthesis is of interest as a target for several antibiotics and for new inhibitor development. Peptidoglycan biosynthesis is a complex process which involves a series of UDP-linked and amine-linked cytoplasmic intermediates assembled …
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Characterization of D-boroala as a novel Broad-spectrum antibacterial agent targeting D-Ala-D-Ala ligase & designer linkers : model reactions and linear free energy relationships in the reactivity and design of solid-phase linkers
Bacterial infections were the major cause of death and morbidity prior to the development of modern antibiotics, and the increasing resistance of pathogenic bacteria to commonly used antibacterial agents is a major public health concern. During our efforts to develop transition-state analog …
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Elucidating Targets for Infectious Diseases and Cancer: A Computational Approach
… targets relating to parasitic diseases, bacterial cell wall biosynthesis, and cancer. These modeling efforts have not only resulted in more potent inhibitors, but have also increased our understanding of these disease targets, which include T. cruzi hexokinase, farnesyl diphosphate …
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The Microbial Ecology of Phenol Degradation in Activated Sludge.
… because 5% phenol causes disruption of the bacterial cell wall and precipitation of proteins. Even lower phenol concentrations can be lethal to bacteria by causing damage to the permeability barrier in the cell wall. A 1% solution has been shown to cause leakage of glutamic acid from …
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The synthesis of aminophosphonic acid derivatives & related compounds
… units in peptide analogues, functioning as antibacterial agents, which inhibit bacterial cell wall biosynthesis; as structural units in peptidic phosphonylating agents that irreversibly inhibit a wide variety of serine proteases; as structural units in butyloxycarbonyl protected phosphonate …
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COMPUTATIONAL MODELING OF BACTERIAL OUTER MEMBRANES AND DEVELOPMENT OF HIGH-THROUGHPUT SCREENING PLATFORM FOR ANTIBIOTICS
… decline in the number of newly approved antibacterial drugs due to a limited understanding of how bacteria adapt to the chemical stress stimuli. The development of antimicrobial resistance is especially true for Gram-negative bacteria that develop resistance to antibiotics readily due to …
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The Impact of Selected Gene Mutations to the Activation and DNA Binding Activity of the Transcription Factor VraR
VraSR two-component system in S. aureus senses bacterial cell wall damage caused by antibiotics (vancomycin or -lactams) and regulates a set of genes. We have undertaken the study of the role of certain amino acids in the function of VraR, which undergo mutation in clinical S. aureus resistant …
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Investigation of CNT-induced Escherichia coli Lysis and Protein Release
… as a treatment to increase the permeability of a bacterial cell wall. Recombinant Escherichia coli BL21 (DE3) containing a plasmid that expressed Green Fluorescent Protein (GFP) and -lactamase were exposed to CNTs under various levels of agitation for different times. Fluorescence assay for GFP, …
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Reguläre bakterielle Zellhüllenproteine als biomolekulares Templat
Bacterial cell wall proteins (S-layer) are - due to both the capability to self-assemble into two-dimensional crystals and their distinct chemical and structural properties - suitable for the deposition of metallic particles at their surface . The cluster growth is subject of this thesis. The …
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Detection of periodontal bacteria in atherosclerotic plaque
… through the molecular identification of latent bacterial species present in atherosclerotic plaque tissue from the carotid artery. Immunohistological examination of the atherosclerotic plaque tissue revealed widespread localisation of the bacterial cell wall constituent peptidoglycan (PGN). …
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Production and characterization of a phage endolysin with putative antimicrobial activity against Cutibacterium acnes
… enzymes from bacteriophages that disrupt the bacterial cell wall. Endolysins retain bactericidal and bacteriostatic activity when applied to bacteria in vitro and are safe for topical application. We hypothesize that the endolysin (ENDL) from the P100.1 C. acnes bacteriophage will exhibit …
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Determining the Structure and Activity of a Pseudomonas aeruginosa Protein, Ivyp2
… system that hydrolyzes the linkages between bacterial cell wall subunits. Further investigation determined that while both isoforms of Ivy also function to inhibit other glycosidic hydrolases, only one of the Ivy proteins from P. aeruginosa (Ivyp1) inhibits lysozyme, while the other (Ivyp2) …
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Multi-target drug discovery against Staphylococcus aureus and Trypanosoma brucei infections
… synthase (UPPS), an essential enzyme involved in cell wall biosynthesis pathway. Besides, they bound to an AT-rich DNA dodecamer (CGCGAATTCGCG)2 and were found to increase the melting transition by up to 24 °C using differential scanning calorimetry (DSC). Good correlations (R2 = 0.89, S. aureus) …
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Assays for lycosyltransferases
… many fundamental biological processes, including cellular adhesion, cell signalling and bacterial cell wall biosynthesis. The aim of this project was the development of operationally simple assays for GTs and their application for the identification and characterisation of novel GT inhibitors. The …
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Photodynamically Activated Multifunctional Chitosan Nanoparticles to Disinfect and Improve Structural Stability of Dentin
… elimination of bacteria and prevention of bacterial recolonization in the root canal system. The major challenge for conventional root canal disinfection strategies is the ability of bacteria to persist as biofilms within the anatomical complexities of the root canal system. In addition, …
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Cell Envelope Modifications By Lcp Family Proteins Of Group B Streptococcus And Virulence Singaling By Peptides Of The Salivaricin Locus Of Streptococcus Pyogenes
<p>ABSTRACT</p> <p>CELL ENVELOPE MODIFICATIONS BY LCP FAMILY PROTEINS OF GROUP B STREPTOCOCCUS AND VIRULENCE SIGNALING BY PEPTIDES OF THE SALIVARICIN LOCUS OF STREPTOCOCCUS PYOGENES</p> <p>by</p> <p>HANNAH MORRISON ROWE</p> <p>December 2014</p> <p>Advisor: Dr. Melody Neely</p> <p>Major: Immunology …
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Molecular Basis of Peptidoglycan Recognition by a Bactericidal Gut Lectin
… antimicrobial proteins by specialized epithelial cells in the intestinal crypts. This molecular arsenal includes the RegIII family. RegIII proteins are novel in that they are C-type lectins that directly kill Gram-positive bacteria and thus play a vital role in antimicrobial protection of the …
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Characterizing the role of central carbon metabolism and cell wall stress responses in Bacillus subtilis cell wall synthesis
The cell wall is an essential organelle for many bacteria since it provides mechanical strength and prevents bacterial cell lysis due to internal turgor pressure. Additionally, the cell wall is the first line of defense against various external stresses. The mesh of peptidoglycan is a major …
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Characterizing the Role of the Type VI Secretion System in Interbacterial Species Interactions and Pathogenesis
… needle complex that spans across the entire bacterial cell wall and functions through a contraction mechanism that results in the delivery of toxic effector proteins into neighbouring cells. Virulence is achieved through the targeting of essential components found in either eukaryotic or …
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