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Showing 1 to 14 of 14 for “"bacterial cell division"”.
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Regulators of Bacterial Cell Division: Investigations of Min Oscillation and Ftsa Activity
… is a fundamental process that is essential for bacterial proliferation. The cytokinetic machinery in bacteria is termed the “divisome”. The divisome is a complex of proteins that forms a ring at midcell over dividing nucleoids. In order for daughter cells to form, the divisome must constrict. As …
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Uncovering the Roles and Evolved Sequence Grammar of Hypervariable Intrinsically Disordered Proteins in Bacterial Cell Division
… of life, a defining hallmark of the onset of cell division is the formation of a cytokinetic ring at the center of the cell. Cell division is a tightly controlled process that involves various regulatory factors that modulate the assembly of the cytokinetic ring. In rod-shaped bacteria, the …
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The essentiality of DivIVAEf oligomerization for proper cell division in enterococcus faecalis and interaction with a novel cell division protein
DivIVA is a Gram-positive cell division protein involved in chromosome segregation, midcell placement of the cell division machinery, complete septum closure, and polar growth and morphogenesis. Although well conserved across various Gram-positive species, DivIVA is believed to be relatively …
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Organization and Regulation of Proteins Required For Initiation of Cell Division In Escherichia Coli
<p>The process of bacterial cell division relies on the assembly of multiple proteins to form the cell division machine, or “divisome.” FtsZ, a bacterial homolog of eukaryotic tubulin, forms a ring-like structure, the “Z ring,” at midcell and serves as a scaffold for divisome assembly and potential …
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Biochemical and structural studies of the FtsZ:FtsA complex and polymerising abilities of the FtsA protein
A key step in bacterial cell division is the formation of the Z-ring composed of polymers of the tubulin-like protein FtsZ. The Z-ring constricts and through interaction with other components engages in remodelling the cell wall and membranes in order to yield two daughter cells. During this …
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Synthesis of FtsZ inhibitors : potential antibiotic agents
… (WHO) acknowledged the immediate threat of antibacterial resistance and the impact it will have on modern medicine. The greatest concern noted was that the development of novel antibacterial compounds was occurring at a slower rate than the development of resistance. One method identified to …
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Characterization of Ftsa-Ftsn Interaction During Escherichia Coli Cell Division
<p>Division of a bacterial cell into two equal daughter cells requires precise assembly and constriction of the division machinery, or divisome. The <em>Escherichia coli </em>divisome includes nearly a dozen essential cell division proteins that assemble at midcell between segregating sister …
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Prosthecobacter BtubAB form bacterial mini microtubules
… segregation, whereas FtsZ is involved in bacterial cytokinesis (bacterial cell division), and the equivalent role of FtsZ is carried out by actin-based and ESCRTIII-based systems in eukaryotes. It seems that there is a big evolutionary gap between αβ-tubulins and FtsZ, and the only …
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Plasmid stability of pUB110 and pUB110-derived plasmids in Bacillus sphaericus 2362
… to remain intact and divide into daughter cells during bacterial cell division) of this plasmid and four plasmids derived from pUB110 was examined. The recombinant plasmids were developed in the laboratory of Dr. William Burke at Arizona State University. Stability was examined under …
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Deciphering the molecular basis of the global emergence of non-tuberculous Mycobacteria as important human respiratory pathogens
… Mycobacteriaceae. They are facultative intracellular bacilli causing opportunistic infections in individuals with pre-existing conditions such as respiratory and immune disorders. There has been a steady increase in the number of NTM infection reports in the past four decades and many of them …
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Biochemical Studies of Peptidoglycan Hydrolases from Commensal and Pathogenic Bacteria
<p>The intestinal microbiota consists of diverse bacterial species and their effectors that play key roles in regulating human health. Interestingly, cell wall, or peptidoglycan, fragments from commensal and pathogenic bacteria can activate host immunity. The mechanism(s) by which immunologically …
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DEVELOPMENT OF SMALL MOLECULES AS INHIBITORS OF FTSZ AND RNPA ACTING AS POTENTIAL ANTIMICROBIAL AGENTS
… 2015). Within the present work, two innovative bacterial targets have been considered to develop new potential inhibitors: FtsZ and RnpA. FtsZ is a 40 kDa protein with 40 -50% of conservation among all bacteria and archaea. This protein represents the main actor of the bacterial cell division …
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Establishing how bacterial cells position the division site
In virtually all bacteria cell division is essential and tightly regulated both temporally and spatially to ensure that cells divide precisely at the centre between segregated chromosomes. Failure to do so can lead to cell death. The earliest event in bacterial cell division is the polymerization …
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Molecular Mechanism By Which The Escherichia Coli Nucleoid Occlusion Factor, Slma, Keeps Cytokinesis In Check
Cell division or cytokinesis is one of the most fundamental processes in biology and is essential for the propagation of all living species. In Escherichia coli, cell division occurs by ingrowth of the membrane envelope at the cell center and is orchestrated by the FtsZ protein. FtsZ self-assembles …