Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"bacterial adhesion"”.
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Bacterial adhesion in structured environments
… The development of materials that prevent bacterial adhesion is therefore of paramount importance, and it requires a thorough understanding of the materials and bacterial surface properties that enable adhesive interactions. We herein design model surfaces and examine the interplay between …
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Bacterial adhesion and detachment from model mineralized biofilms
… of calcium carbonate precipitates on pathogen adhesion to and detachment from biofilms. Thus far, the research focus has been to create an agarose hydrogel with similar elastic moduli to real biofilms in order to perform systematic studies of calcium carbonate precipitation within the gel. …
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Investigating bacterial adhesion proteins as tools for controlling bacteria-surface interactions
… explored as ways of altering the targeting of bacterial colonization. In one, redesigned and shortened versions of the M. primoryensis ice- and diatom-binding adhesin were tested for expression in Escherichia coli. In particular, the number of extender domains was reduced from 120 in the wild …
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The Synthesis of Amphiphilic Glycolipids as Potential Inhibitors of Bacterial Adhesion
The synthesis of glycolipids as potential anti-bacterial agents and glycolipid mimetics is the main focus of the research presented in this thesis. A variety of glycolipids based around an aspartic acid, aliphatic or aromatic scaffold were investigated. Chapter 1 describes the biological importance …
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Coating of Polyvinylchloride for Reduced Cell / Bacterial Adhesion and Antibacterial Properties
… by coating a biocompatible, hydrophilic and antibacterial polymer by a mild surface modification method. The surface was first activated and then functionalized, followed by coating with polymer. The surface functionality was evaluated using cell adhesion, bacterial adhesion and bacterial …
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Role of disinfectants and pipe materials on bacterial adhesion onto biofilms
… The fact that biofilms can protect attached bacterial cells from disinfectants raises rudimentary questions regarding interactions of bacterial cells with biofilm surfaces. Consequently, the main objectives of this study were to: 1) investigate the mechanisms that govern E. coli S17, E. coli …
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Anti-Adhesive Si-and F-Doped DLC Coatings and Micro-Nanostructured Surfaces for Medical Implants
… and micro-nanostructured surfaces with anti-bacterial properties for biomedical applications. In this study a DLC coating and Si- and F- doped DLC coatings with various Si and F contents were prepared by a radio frequency plasma-enhanced chemical vapor deposition (rf-PECVD) technology. Under …
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Development and Evaluation of NI-P-PTFE Based Nano-Composite Coatings for Medical Devices
… by developing a new coating which can reduce bacterial adhesion and slow down the corrosion behaviour efficiently.<br/><br/>In this study, two kinds of Ni-P-PTFE based coatings including Ni-P-PTFE-ZrO2 and Ni-P-PTFE-ZrO2-TiO2 were developed by electroless plating technique. The assays of …
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Development and evaluation of anti-biofouling nano-composite coatings
… and nano-structured surfaces were evaluated with bacterial strains that frequently cause heat exchanger biofouling or medical devices-related infections. The experimental results showed that new Ni–P–PTFE-biocide polymer nanocomposite coatings reduced bacterial adhesion by 70% and 94% …
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The Design of Antimicrobial Detachable Thin Films for the Study of Hepatic Infections
… in the presence of LL-37modified PEMs in bacterial adhesion and contact killing models. Physisorbed LL-37 PEMs prevented bacterial adhesion and could also kill pathogens in the surrounding environment due to the release of LL-37 from the film. Immobilized LL-37 PEMs resulted in less …
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Controlling Microbial Adhesion to the Surfaces Using Topographical Cues
The state of adhesion of bacteria to nanofiber-textured model surfaces is analyzed at single-cell level. The results reveal similarities between the effect of topography on bacteria-surface interactions and vesicle-surface interactions. The results are discussed in the context of controlling …
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Silver Doped Hydroxyapatite Coating on Titanium Surfaces and its Effect on Early Bone Response and Osseointegration
… has on osteoblastic activity as well as decrease bacterial load has yet to be determined.</p> <p>In this study, the effect of Ag-doped HA coatings on initial bacterial adhesion and osteoblast cell proliferation, differentiation, and mineralization was investigated. Using a sol-gel process, HA …
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Study of the effect of mechanical stiffness substrata, assembled with polyelectrolyte multilayer thin films, on biofilm forming staphylococcus epidermidis' initial adhesion mechanism
… Currently mechanisms responsible for the initial adhesion of bacteria are not completely understood. Previous work completed in the Rubner and Van Vliet labs at MIT suggests a mechanoselective adhesion mechanism in prokaryotes. The existence of a positive correlation between mechanical stiffness …
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Design of bio-inspired texturing treatments, via high power ultra-short pulse lasers, of ferritic stainless steel surfaces that inhibit the formation of bacterial biofouling on tools for hospital use and in the food industry
… capacity to adhere to different surfaces. This adhesion process results in the formation of biofilms. The significance of these biostructures lies in the fact that the bacteria within them acquire new properties, such as increased resistance to antibiotics and unfavorable external conditions. …
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Optimization of antimicrobial chitosan coating for silicone
… the first place. This can be achieved with antibacterial, biocompatible coatings that resist bacterial adhesion, colonization, and biofilm growth. The current project focused on developing antimicrobial coatings, based on chitosan, for silicone elastomers, a common material in implants and other …
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Preparation and Biocompatibility of Electrospun Zwitterionic Poly(Sulfobetaine Methacrylate) for Wound Dressing Applications
… to protein adsorption and cell attachment. Bacterial adhesion studies using Gram negative P. aeruginosa and Gram positive S. epidermidis showed that the PSBMA electrospun membrane was also highly resistant to bacterial adhesion. The Ag+-impregnated electrospun PSBMA membrane was shown …
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Effects of Surface Topography on Bacterial Biofilm Formation
<p>Biofilms are multicellular structures with bacterial cells attached to a surface and embedded in an extracellular matrix. With high-level resistance to antimicrobial agents, biofilms are the cause of chronic infections associated with implanted medical devices such as breast implants, orthopedic …
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Effect of Physical and Chemical Cues on Candida albicans Morphological Expression and Biofilm Formation
… have been found to have significant effects on bacterial adhesion and biofilm formation, but their effects on fungal pathogens are less explored. This thesis systematically explores the effect of surface topography in the form of nano and microscale polymeric fibers (~0.4-1.2 µm in diameter) on …
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