Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"baccatin"”.
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A New Synthesis of Taxol®, from Baccatin III
… economical. Another natural product, 10-deacetyl baccatin III, is readily available in higher yield. Several methods have been reported for the synthesis of Taxol by coupling baccatin III and the N-benzoyl-β-phenylisoserine side chain. A new method for the synthesis ofTaxol from baccatin III is …
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Chemical studies of the C-4 position of baccatin III and taxol
… studies of the deacylation and reacylation of baccatin III were carried out in order to find conditions necessary for the preparation of 4-deacetylbaccatin III, and hence 4-deacetyltaxol. 4-Deacetyltaxol has now been prepared from baccatin III via two synthetic approaches and from taxol via one …
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Approaches to the synthesis of modified taxols
… side chain acid chloride to a suitably protected baccatin III. The side chain was prepared by the Darzens condensation. Acylation of baccatin III was performed with simple acylating agents and extensive studies of the ¹H NMR and ¹³C NMR spectra of various acylbaccatins III were carried out aided …
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Studies on the chemistry of taxol
… of the deacylation and reacylation reactions of baccatin 111 was carried out in order to find conditions suitable for the preparation of 2-debenzoylbaccatin Ill , and thus 2-debenzoyltaxol. Finally, the reactions of taxol with various electrophilic reagents were investigated, and the structures …
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Experimental and Computational Studies in Bioorganic and Synthetic Organic Chemistry
… we synthesized Taxol-based dimer in which the baccatin III core of Taxol is coupled with flexible PEG linker. However, microtubule assembly assay suggested that these new dimers are not capable of effecting bivalent binding to the Taxol binding sites in microtubules. Memory of chirality (MOC) …
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The chemistry of cephalomannine
… prepared by coupling a protected side chain to baccatin III, deprotecting, and acylating the resulting free amine. This methodology was used to prepare several oxalyl and halogenated analogs as well as N-(phenylglyoxyl) and N-crotonyl derivatives. One derivative in particular, …
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Design, Syntheses and Biological Activities of Paclitaxel Analogs
… an aza-tricyclic moiety as a mimic of the baccatin core of paclitaxel have been designed and synthesized as water-soluble simplified paclitaxel analogs, among which 3.50-3.52 and 3.55 were conformationally constrained analogs designed to bind to the paclitaxel binding site of tubulin, based …
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Synthesis and Biological Evaluation of Paclitaxel Analogs
The complex natural product paclitaxel (Taxol®), first isolated from Taxus brevifolia, is a member of a large family of taxane diterpenoids. Paclitaxel is extensively used for the treatment of solid tumors, particularly those of the breasts and ovaries. In order to obtain additional information …
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Synthesis of Paclitaxel Analogs
Paclitaxel is one of the most successful anti-cancer drugs, particularly in the treatment of breast cancer and ovarian cancer. For the investigation of the interaction between paclitaxel and MD-2 protein, and development of new antagonists for lipopolysaccharide, several C10 A-nor-paclitaxel …