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Showing 1 to 20 of 23 for “"bHLH transcription factor"”.

  1. Identification of an aqueous glue protein, SCP-2, and the development of a polyclonal antiserum against the bHLH transcription factor SGSF in Latrodectus Hesperus

    La Mattina, Coby Ann2018

    … to advance our understanding regarding silk gene transcription, our lab has developed the first antibody against the bHLH factor SGSF. SGSF has been implicated as a potential transcriptional regulator of silk gene transcription in spiders. Development of the anti-SGSF antibody was accomplished via …

    u-pacific Repository record

  2. Part I characterization of MyoR in C2C12 mouse fibroblasts. Part II isolation and characterization of a novel class II bHLH transcription factor from the black widow spider, latrodectus hesperus

    Thayer, William R.2004

    <p>PART I</p> <p>The basic helix-loop-helix (bHLH) family of transcription factors are involved in a variety of developmental processes. MyoR is the mouse homologue of the human transcription factor ABF-1 . MyoR is classified as a class II basic-helix-loop-helix transcription factor. In order to …

    u-pacific Repository record

  3. Covalent modification and intrinsic disorder in the stability of the proneural protein Neurogenin 2

    McDowell, Gary StevenUniversity of Cambridge2011

    Neurogenin 2 (Ngn2) is a basic Helix-Loop-Helix (bHLH) transcription factor regulating differentiation and cell cycle exit in the developing brain. By transcriptional upregulation of a cascade of other bHLH factors, neural progenitor cells exit the cell cycle and differentiate towards a neuronal …

    cambridge Repository record

  4. Transcriptional Regulation of Adult Neurogenesis by NRSF/REST and NeuroD1

    Ure, Kerstin Maria2011

    … many external stimuli. Two critical regulatory factors in this process are NRSF/REST and NeuroD1. NRSF/REST, a transcriptional repressor that binds a specific NRSE site and recruits corepressors and chromatin remodeling machinery to repress its target genes, is critical for maintenance of the …

    utswmed Repository record

  5. Characterization of ABF-1 in C. elegans and regulation of cellular growth and ID3 by human ABF-1

    Round, June L.2002

    <p>ABF -1 is a human class II bHLH transcription factor that is expressed predominantly in activated B cells and EBV immortalized cell lines. A portion of this study sought to characterize the homolog of ABF- l in Caenorhabditis e/egans. The nematode gene product, ceABF -1, is capable of forming …

    u-pacific Repository record

  6. Control of Cardiac and Limb Development by the bHLH Transcription Factors DHAND and eHAND

    McFadden, David Glenn2010

    Members of the basic helix-loop-helix (bHLH) transcription factor family regulate the specification and differentiation of multiple cell lineages during embryonic development. The bHLH proteins dHAND and eHAND are expressed in complimentary and overlapping patterns during embryogenesis, and gene …

    utswmed Repository record

  7. Analysis of ASCL1 in Neuroendocrine Lung Cancer

    He, Min2017

    … have determined that the basic helix-loop-helix (bHLH) transcription factor achaete-scute homolog 1 (ASCL1) is essential for the survival and progression of many pulmonary neuroendocrine (NE) cancer cells, which include both SCLC and some non-small cell lung cancer (NSCLC). To understand how ASCL1 …

    utswmed Repository record

  8. Mapping of the repression domain and the subcellular localization of the ABF-1 protein

    Wong, Jerelyn J.2001

    <p>Basic helix-loop-helix transcription factors play important roles in pathways that result in the formation of such tissues as skeletal muscle, the nervous system, pancreas and heart. A recently discovered B-cell restricted bHLH transcription factor activated Bcell factor 1 (ABF -1) is suspected …

    u-pacific Repository record

  9. Roles of Neurogenin and Geminin in Vertebrate Neurogensis

    Lim, Jong-Won

    … neurogenesis Proneural basic helix-loop-helix transcription factors regulate cell fate commitment and differentiation in neurogenesis. However, their proneural functions are not well understood, in part due to a lack of information about their target genes. Here, we identified direct …

    wustl Repository record

  10. The characterization of the ABF-1 promoter

    Ezpeleta, Jessica2018

    <p>The basic helix-loop-helix (bHLH) family oftranscription factors consists of proteins involved in cellular proliferation and differentiation. The HLH structure plays a key role in protein-protein dimerization and with the DNA target sites, referred to as E boxes containing the consensus DNA …

    u-pacific Repository record

  11. A Map of Transcription Factor Expression in Neuronal Precursors of the Chicken and Mouse Embryonic Cerebellum

    Morales, Daniver

    … of various members of the TALE, LIM and bHLH transcription factor families in the avian and murine cerebellar anlagen. We show here that the combinatorial expression of transcription factors Irx3, Meis1, Meis2, and Lhx2/9 defines neurons of the CN, and that the combinatorial expression of …

    rockefeller Repository record

  12. TCF4 Is a Key Mediator of Cell Identity and Oncogenesis in Neuroblastoma

    Aljouda, Nour2023

    … (MES) cell state. Super-enhancer-associated transcription factor (TF) networks define cell identities in neuroblastoma (NB). Dysregulation of these TFs contributes to the initiation and maintenance of NB by enforcing early developmental identity states. We report the bHLH transcription factor …

    tenn-hsc Repository record

  13. Early land plant origins of the MYB-bHLH-WDR complex

    Kongsted, TheaUniversity of Cambridge2023

    … types in the seed plant epidermis. Tripartite transcriptional complexes composed of a MYB transcription factor, a bHLH transcription factor and a WD repeat scaffold (MYB-bHLH-WDR or MBW complexes) regulate patterns of flavonoid pigments, trichomes and root hairs in this cell layer. We reasoned …

    cambridge Repository record

  14. Characterization of Neural Stem Cells Using the Nestin Enhancer

    유, 순태2011

    … that ngn1, which is a basic helix-loop-helix (bHLH) transcription factor that is expressed in neuronal precursors during development of the nervous system, can promote nestin expression by nestin enhancer located on nestin 2nd intron. Two E-boxes (CANNTG) in 637bp of the nestin 2nd intron …

    ajou Repository record

  15. Understanding the molecular mechanism of postharvest seed coat darkening in pinto beans

    Islam, Nishat ShayalaThe University of Western Ontario2022

    … research objective, a basic-Helix-Loop-Helix (bHLH) transcription factor encoding the P (Pigment) gene was identified in pinto beans. P protein in a regulator of proanthocyanidins (PAs) biosynthesis. Using genetic complementation, transcript abundance, metabolite analysis, and inheritance …

    uwo Repository record

  16. RBP-L and RBP-J Have Critical Roles in the Functioning of Two Forms of the Pancreas Transcription Factor Complex PTF1

    Beres, Thomas MatthewUT Southwestern Medical Center2005

    … regulated by a complex network of signaling and transcription factor pathways. P48 is a tissue-specific basic-helix-loop-helix (bHLH) transcription factor, which is essential for pancreas development and function. Mice lacking both p48 alleles lack an exocrine pancreas and have a greatly reduced …

    utswmed Repository record

  17. Transcriptional Regulation of Cardio-Pulmonary Development

    Aiyer, Aparna R.2010

    … protein is dHAND, a basic helix-loop-helix (bHLH) transcription factor that is required for normal development of the right ventricle, the pharyngeal arches and limb buds. Loss of dHAND leads to apoptosis in the aforementioned tissues and to embryonic lethality at E10.0. A differential …

    utswmed Repository record

  18. Circadian regulation and phytohormone responses of cytochrome P450 monooxygenase genes in Arabidopsis

    Pan, YinghongUniversity of Illinois at Urbana-Champaign2013

    … Arabidopsis thaliana as circadian-regulated at a transcriptional level under varying photoperiod and thermocycle conditions, and demonstrated that P450s involved in phenylpropanoid, carotenoid, oxylipin, glucosinolate and brassinosteroid biosynthese pathways are circadian-regulated. The next phase …

    uiuc Repository record

  19. Transcriptional and Translational Regulation of Cardiac Progenitors in the Mouse and Zebrafish

    Cordes, Kimberly Rene2010

    … among the first cell lineages to be established. Transcriptional networks control the specification of cardiac progenitors, however, it is not fully understood how some transcription factors function in particular cardiac progenitor populations. The basic helix-loop-helix, bHLH, transcription …

    utswmed Repository record

  20. Neurogenesis and Gliogenesis from Ascl1 (Mash1) Expressing Progenitors in the Central Nervous System

    Kim, Euiseok Joshua2010

    … coordinated manner. Basic helix-loop-helix (bHLH) transcription factors play central roles in determining distinct neural cell fates and thus contribute to mechanisms controlling neural cell type diversity during the embryogenesis. Fundamental to understanding nervous system formation is to …

    utswmed Repository record

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