Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"bHLH/PAS"”.
-
The bHLH/PAS Transcription Factor SIM1 Is a Novel Obesity Gene
Obesity is epidemic in the United States and other developed countries. Obesity is a major risk factor for type II diabetes, hypertension, hyperlipidemia and osteoarthritis. I report a unique girl with early-onset obesity (47.5 kg, +9.3 s.d. above mean at age 67 months) and a de novo balanced …
-
Analysis of the Role of bHLH/PAS Proteins in Aryl Hydrocarbon Receptor Signaling
… (AHR) is a basic helix-loop-helix PER/ARNT/SIM (bHLH-PAS) transcription factor that binds ligands typified by 2,3,7,8-tetracholordibenzo-p-dioxin, translocates to the nucleus, dimerizes with the aryl hydrocarbon nuclear translocator (ARNT) and associates with specific cis xenobiotic response …
-
Investigating mechanisms and biological functions of the bHLH/PAS transcription factors SIM1 and ARNT2
The basic Helix-Loop-Helix/PER-ARNT-SIM (bHLH/PAS) family of transcription factors are involved in gene regulation during both embryonic development and throughout adulthood to maintain cellular homeostasis. Members of this family must heterodimerise to activate or repress target gene expression. …
-
Molecular Mechanisms Underlying Functions of Juvenile Hormone Receptor
… gene regulation by JH via Met. Met is a bHLH-PAS (basic-helix-loop-helix Per-ARNT-Sim) family protein. Many proteins in this family function as heterodimers formed with other proteins of this family. In a yeast two-hybrid screening, we discovered that another bHLH-PAS family protein, …
-
A Fragile Native State Structure: An Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Variant Exhibits Slow Interconversion Kinetics Between two Different Folds
… helix-loop-helix Period/ARNT/Single-minded (bHLH-PAS) protein that controls various biological pathways by forming heterodimeric transcriptional regulator complexes with several other bHLH-PAS proteins via the beta-sheet surfaces of its two PAS domains. The beta-sheets of PAS domains are …
-
Role of Amino Acid 926-977 in Drosophila PERIOD Protein for Circadian Clockworks
… feedback loop이다. 초파리 feedback loop의 첫 번째 loop에서는 bHLH/PAS 도메인을 함유한 전사인자인 dCLOCK (dCLK) 과 CYCLE (CYC) 가 dperiod (dper)와 timeless (tim) 의 발현을 촉진하고 합성된 dPER 단백질과 TIM 단백질이 이합체로 결합하여 dCLK/CYC의 전사활성을 억제하여 dper 와 tim 의 발현이 하루를 주기로 진동케 한다. 여기에는 dPER에 의한 dCLK/CYC 전사활성의 억제가 필수적이다. 본 연구에서는 dPER에서 dCLK/CYC의 …
-
Characterization of an aryl hydrocarbon receptor from a cetacean : an approach for assessing contaminant susceptibility in protected species
… aryl hydrocarbon receptor (AHR), a member of the bHLH-PAS family of transcription factors. Differences in AHR structure and function are known to contribute to species-specific differences in susceptibility to HAH toxicity, and targets for HAH toxicity are related to the tissue-specific expression …
-
Neuronal PAS Domain 1 Protein and Its Hypothetical Relationship to Autism
Neuronal PAS domain 1 (NPAS1) was discovered in 1997 as a brain-specific transcription factor first detected at embryonic day 15 of the developing mouse embryo. Its expression was observed to peak in the early post-natal days, and in situ hybridization assays in adult mice revealed expression …
-
Analysis of the aryl hydrocarbon receptor and a truncated form (AHR C[upper case symbol for greek Delta]Δ553) in cancer cells
… hydrocarbon receptor (AhR) is a ligand-activated bHLH-PAS protein that binds its partner, the aryl hydrocarbon receptor nuclear translocator (Arnt), in the nucleus to initiate the expression of proteins involved with detoxification. Published work suggests cross-talk between both proteins and …
-
Role of Aryl Hydrocarbon Receptor in Circadian Rhythm: A Novel Pathway to Dioxin Toxicity
… of the basic helix-loop-helix/Per-ARNT-Sim (bHLH-PAS) domain family, has been focused on its role in mediating adverse effects of some environmental contaminants, such as 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD). However, a physiological role of AhR remains unknown. Many members of PAS …
-
REGULATION OF CIRCADIAN CLOCKS AND METABOLISM BY SYNTHETIC AHR AGONIST BETA-NAPHTHOFLAVONE IN MICE
… to the basic helix-loop-helix/Per-Arnt-Sim (bHLH-PAS) domain family. Previous studies have linked AhR signaling to circadian rhythm. Importantly, activation of the AhR can impair transcriptional activity of the CLOCK: BMAL1 heterodimer in cultured cells. However, because the AhR is …