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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"bFGF"”.
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Effects of bFGF (Basic Fibroblast growth factor) on the Haematopoietic Sequelae that follow transplantation
… transplantation (BMT), we studied the effects of bFGF, a cytokine known to stimulate the survival and proliferation of fibroblasts, on the propagation of clonogenic progenitors and the marrow stroma. METHODS: In order to obtain the optimal bFGF concentrations to be used on patients' haematopoietic …
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Characterization of the Effects of bFGF and GSK3β Inhibitors on Embryoid Bodies Derived from Human Pluripotent Stem Cells
… that contains basic fibroblast growth factor (bFGF), a trophic factor often used in hPSC cultures to maintain self-renewal. This distinguishes feeder independent hPSCs from feeder dependent hPSCs. The purpose of this study was to characterize the effects of bFGF as well as small molecule …
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Purification and Characterization of Proteoglycan from Bovine Aortic Endothelial Cells Conditioned Media, and its Interaction with Basic Fibroblast Growth Factor (bFGF)
… which bound basic fibrobalst growth factor (bFGF). bFGF is a known mitogen for vascular smooth muscle cells, and is indicated to have a role in some proliferative vascular disorders. In the present study, we have purified proteoglycans from BAE cells conditioned media (BAE PG), and further …
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Differential Regulation of Iress In The Aurora A Mrna By Bfgf Through The Mtor Complex to rc2 Modulates Aurora A Kinase Expression
… Aurora A IRESs. I found that addition of bFGF enhances Aurora A protein expression within 2 hours. Moreover, bFGF led to an increase in exon 1b and exon 2a but not exon 2 IRES activity. Further study showed that the translational response was mediated through the mTOR pathway. …
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The role of basic fibroblast growth factor in the compensatory adrenal growth response
… the role of basic fibroblast growth factor (bFGF) in the neurally mediated compensatory adrenal growth response. Unilateral adrenalectomy resulted in a 13%, 6% and 22% increase in adrenal weight, protein and DNA content, respectively, and 33-40% increases in the rate of cell proliferation …
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Role of basic fibroblast growth factor in the development of sensitization to the effects of amphetamine
… hypothesis that basic fibroblast growth factor (bFGF), a neurotrophic factor produced by astrocytes, plays a crucial role in the development of sensitization was tested. A series of experiments was conducted to assess whether bFGF expression in cell body regions of dopaminergic neurons is altered …
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Design and Application of Chitosan/biphasic Calcium Phosphate Porous Scaffolds for Bone Tissue Engineering
… relevant sizes and implanted with and without bFGF into a porcine mandibular defect model. Tissue engineered constructs facilitated the healing of mandibular defects only if combined with delivery of bFGF via gelatin microspheres. bFGF release from the constructs improved neovascularization in …
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Molecular and cellular regulation of motoneuron differentiation of human neural stem cells
… consisting of basic fibroblast growth factor (bFGF), heparin and laminin (FHL), which directs human fetal neural stem cells (hNSCs) to differentiate into choline acetyltransferase (ChAT) motoneurons in vitro and after transplantation into the rodent spinal cord in vivo. However, the mechanisms …
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Wirkung angiogenetischer Wachstumsfaktoren auf regionale Funktion und regionale Perfusion am porcinen, chronisch-ischämischen Myokard
… Nach Randomisierung erhielten die Tiere 500μg bFGF-Protein (n=6), 2mg bFGF-Plasmid (n=7), 2mg VEGF-Plasmid (n=7), Pacebo (n=3) bzw. keine Therapie (n=6). Der Erfolg der Therapie wurde nach drei Monaten überprüft. <br>Nach einer Woche Ischämie reduzierte sich die segmentale myokardiale …
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The Effects of Angiogenic Growth Factors on Mesenchymal Stem Cell Proliferation and Differentiation to Vascular Cell Fates
… the effects of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF), two of the best-characterized angiogenic factors, on MSC proliferation and differentiation. We hypothesized that treatment with these two factors could inhibit mural cell character and promote …
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Humna fetal neural stem cells: Proliferation and differentiation in response to growth factors and role in locomotor recovery after spinal cord contusion injury
… regimens with basic fibroblast growth factor (bFGF), epidermal growth factor (EGF) and leukemia inhibitory factor (LIF), either alone or in combinations. We found that a combination of bFGF, EGF and LIF expanded hNSCs more efficiently than any other treatment. Differentiation patterns of hNSCs …
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Stanovení biologické aktivity rekombinantního proteinu adiponektinu pomocí buněčné kultury
… buněk pomocí růstových faktorů HB-EGF, PDGF-BB a bFGF v různých koncentracích. Biologická aktivita adiponektinu poté byla stanovena jako inhibice stimulace růstu s 5 ng/ml PDGF-BB. Test biologické aktivity adiponektinu byl také proveden s lyofilizovaným adiponektinem a růstovým faktorem bFGF (0,1 …
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Opioid inhibition of the growth of the transplantable androgen-responsive (AR) Shionogi mouse mammary carcinoma (SC115)
… basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), anti-bFGF antibody with either DHT or bFGF, or anti-EGF antibody with either E2 or EGF. After 48 h, some of the cultures were exposed to 10-14-10-7 M of either 8-endorphin (5-EP), which binds to the 8 opioid …
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Schaffung dreidimensionaler Kapillarnetze in extrazellulären Kollagenmatrices aus genmodifizierten humanen Endothelzellen.
… drei verschiedene Wachstumsfaktoren getestet: bFGF, VEGF und EGF. Zwei extrazelluläre Matrices: TissuVlies und Matrigel <br>wurden auf Stabilität und Eignung zur Endothelzellimplantation getestet. Humane Endothelzellen, sogenannte HUVEC, wurden aus Nabelschnüren isoliert und in speziellem …
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The prevention of heparanase expression in endothelial cells injured by high glucose
… (1 U/ml) and/or basic fibroblast growth factor (bFGF, 1 ng/ml) to determine if these compounds protected ECs from injury or inhibited heparanase expression induced by high glucose. p* PAECs injured by high glucose or heparinase I (0.3 U/ml in serum free medium) showed a significantly decreased …
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Nuclear Basic Fibroblast Growth Factor Regulation of Triple-Negative Breast Cancer Dormancy/Recurrence
… we identify a novel signaling axis [nuclear bFGF/DNA-dependent protein kinase (DNA-PK)] supported by chemotherapy-enriched dormant TN breast cancer cells. This signaling axis drives accelerated DNA repair in chemo-residual TN breast cancer cells. Targeting this axis with either with a bFGF …
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Stimulation of angiogenesis through growth factor delivery from synthetic heparinised hydrogels
… (VEGF) and basic fibroblast growth factor (bFGF), as well as their bioactivity and angiogenic potential in vivo. Methodology: VEGF and bFGF were combined into 4% (m/v) PEG-Hep hydrogels. The binding and release rates of VEGF and BFGF were analysed via an immunosorbent assay. Released growth …
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A Method to Improve Cartilage Integration
… Each of the chemotactic agents tested (PDGF-bb, bFGF, and IGF-I) were found to induce bovine chondrocyte chemotaxis at concentrations of 25 ng/mL in modified Boyden chamber experiments. However, in bovine articular cartilage samples that were pre-treated with collagenase (0.6% for 10 min), …
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Evaluation transgener und transmuraler Myokardrevaskularisation am chronisch ischämischen Modell anhand objektiver Parameter der regionalen und globalen Funktion
… kamen ein CO2-Laser und die Wachstumsfaktoren bFGF und phVEGF121 in einem porcinen Modell chronisch myokardialer Ischämie. Eine Woche nach Anlage einer hochgradigen, proximalen RIVA-Stenose wurden die Schweine - nach Bestimmung der regionalen (SMV) und der globalen Funktion (dP/dt und LVSWI) in …
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Integrin Alpha Subunit Ratios, Cytoplasmic Domains, and Growth Factor Synergy Regulate Muscle Proliferation, Differentiation, and Signaling
… from their effects on untransfected cells. bFGF or TGF$\beta$ inhibit the serum-free differentiation of $\alpha$5 transfected myoblasts. bFGF stimulates proliferation whereas TGF-$\beta$ inhibits it. Insulin or TGF-$\alpha$ promote proliferation and differentiation; insulin alters myotube …
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