Global ETD Search
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Showing 1 to 15 of 15 for “"azoxymethane"”.
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Elevated colorectal cancer risk in the hnRNP I knockout mice treated with azoxymethane/dextran sulfate sodium
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms
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Inflammation enhanced colon cancer & natural anti-cancer plant compounds
… colon cancer, using the dextran sulfate sodium/ azoxymethane mouse model. GKB (500 µmol/kg diet daily), GE (providing an equal dose of GKB) and broccoli protected against some aspects of inflammation, including cyclooxygenase-2 levels in colonic mucosa. The extract and the 10% broccoli diet, but …
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The Effect of the Microbiome on DNA Methylation
… the colitis-associated cancer inducing compound, azoxymethane (AOM). We found that individually, inflammation and the microbiota induce moderate changes in the methylation profiles of the large intestine. However, their effects on DNA methylation seem to synergize; in the presence of inflammation, …
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Impact of Epa and Dha Supplementation and 15-Lox-1 Expression On Colitis and Colitis-Associated Colorectal Cancer
… and chronic colitis, or with DSS following an azoxymethane injection to induce CAC. In the chronic colitis model, DHA diet and/or expression of 15-LOX-1 reduced inflammation and altered immune cell populations. In the CAC model, DHA reduces tumor numbers by 54% in the WT/DHA group and by 52% in …
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Effects of synbiotics on cancer risk biomarkers
… previously shown that synbiotic consumption in Azoxymethane treated rats modulates the immune system, influences the genotoxic potential of caecal contents and reduces the number of colonic tumours compared to control rats who did not receive the synbiotic. The aim of the current study was to …
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The mechanism of action of the anticancer effects of selenomethionine on colon cancer
… and 2ppm) for 16 weeks to male F344 rats in the azoxymethane (AOM) rat colon carcinogenesis model. The results showed no significant changes in colonic polyamine levels, however, there were significant changes in the development of microadenomas between control and treated groups. …
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Grape Seed Extract as an Adjunct for Modulating Colon Carcinogenesis
… GSE in an in vivo model of human colon cancer, azoxymethane (AOM) was used to induce pre-neoplastic colonic lesions in male Fischer 344 rats. These pre-neoplastic lesions are termed aberrant crypt foci (ACF). Both ACF and ACF with multiplicity (ACF with four or more aberrant crypts within a …
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Dietary Protein Concentration and the Metabolism of 1,2-Dimethylhydrazine by Mice
… ranging from 2.5 to 10 mM, DMH and azoxymethane (AOM) did not increase the mutation frequency of Salmonella typhimurium (Strain G-46) in vitro. Murine liver microsomes and cofactors caused a 40-fold increase in mutation frequency with dimethylnitrosamine (DMN) but not with DMH or AOM …
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The Effects of Time-Restricted Feeding on Early Phases of Liver and Colon Carcinogenesis
… tumor development. For colon carcinogenesis, azoxymethane (AOM) was administered in 2 doses for two consecutive weeks to initiate the process. Following the carcinogen administration, rats were assigned to either a high-fat diet (HFD) or a low-fat diet (LFD), and then further subdivided into …
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Molecular Mechanisms of American Ginseng For the Prevention and Treatment of Colitis and Colon Cancer Associated With Colitis
… associated with colitis (Chapter IV). Using the azoxymethane (AOM)/dextran sulfate sodium (DSS) mouse model of UC, we show that AG can suppress colon cancer associated with colitis. To explore the molecular mechanisms of the anti-cancer effects of ginseng, we also carried out antibody array …
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Epigenetic modifications on WNT genes by dietary genistein during colon cancer development
… viability and increased apoptosis. By using an azoxymethane (AOM)-induced rat colon cancer model, we examined the ability of genistein to modify the epigenetic structure of Wnt signaling genes, which have been shown to be closely involved in colon carcinogenesis. Male Sprague-Dawley rats were …
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Anti-inflammatory and anti-colon cancer potential of yerba mate (Ilex paraguariensis St. Hilaire) bioactive constituents
… lesions, aberrant crypt foci (ACF), in the azoxymethane (AOM)-induced model using male F344 rats. The animals received a basal diet and a mate aqueous extract (2% w/v) as drinking fluid, or mate saponins (0.01%, w/w) mixed with the basal diet 2 weeks before AOM injection and throughout the …
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Inhibitory potential of anthocyanins and anthocyanin-rich extracts on colorectal cancer progression through apoptosis, angiogenesis, and immune response effects
… lentil water extract and D3G-enriched extract on azoxymethane (AOM) and dextran sodium sulfate (DSS) induced colitis-associated carcinogenesis. The black lentil group had a lower disease activity index throughout and at the end of 2.4 compared to 6.3 of the AOM/DSS control (p<0.05). Mice in the …
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Morphological Features of Dysplastic Progression in Epithelium: Quantification of Cytological, Microendoscopic, and Second Harmonic Generation Images
<p>Advances in imaging technology have led to a variety of available clinical and investigational systems. In this collection of studies, we tested the relevance of morphological image feature quantification on several imaging systems and epithelial tissues. Quantification carries the benefit of …
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The Effects of Metronomic and Maximum-Tolerated Dose Chemotherapy in Colorectal Cancer Angiogenesis: A Combined Approach Using Endoscopic Diffuse Reflectance Spectroscopy and mRNA Expression
<p>Colorectal cancer (CRC) continues to be one of the most incident and deadliest types of cancer worldwide. Chemotherapy has proven effective to reduce tumor burden for CRC patients, but there are several disadvantages associated with the use of mainstay maximtolerated dose (MTD) chemotherapeutic …