Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"azithromycin"”.
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Investigation of azithromycin analogues and proteasome-like inhibitors as quick-killing antimalarials
… future as treatments. The macrolide antibiotic azithromycin is known to target the malaria parasites remnant plastid organelle (the apicoplast’s) bacterial-like ribosome and causes slow-killing ‘delayed death’, where the parasite dies in the second replication cycle (4 days). Azithromycin has …
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Degradation of 23S rRNA in Azithromycin-Treated Ribonuclease Mutants of <em>Escherichia coli</em>.
<p>Azithromycin, a macrolide antibiotic, specifically binds to the 50S ribosomal subunit of bacterial ribosomes and inhibits translation. Azithromycin also prevents 50S ribosomal subunit assembly by binding to a 50S ribosomal subunit precursor particle. When exposed to azithromycin, several …
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Development of an inhaled liposomal-loaded azithromycin formulation for the treatment of chronic respiratory infection
… frequency and improve quality of life. Azithromycin is often given orally for this purpose with its benefit thought to be due to a dual antibacterial and anti-inflammatory effect. In this thesis, the aim was to develop an inhaled liposomal loaded azithromycin formulation that could be …
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The effect of long-term azithromycin treatment on the respiratory microbiota of HIV-infected children with chronic lung disease
… clinical trial demonstrated that long-term azithromycin therapy reduced the frequency of acute respiratory exacerbations and all-cause hospitalisations in HCLD patients. However, our understanding of the microbial determinants of HCLD and how azithromycin therapy modulates these determinants …
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Trends in Chlamydia trachomatis Treatment Prescribing Practices in King County, Washington, 2010 - 2018
… guidelines from equally recommending either azithromycin (1 gram as a single dose) or doxycycline (100mg twice daily for 7 days) to only recommending doxycycline as first line treatment after 2021.We conducted a trends analysis using the Washington STD surveillance database to understand …
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Macrolide Resistance in Mycobacterium avium
… avium isolates resistant to clarithromycin and azithromycin have been recovered from patients undergoing antibiotic therapy. Comparison of DNA fingerprints of sensitive and resistant isolates showed that resistance resulted from mutation of the original, sensitive isolate in five of seven …
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Identifying cross-species regimens for the treatment of rapid-growing and slow-growing nontuberculous Mycobacterium pulmonary infections
… but had variable performance across models. Azithromycin and ofloxacin were also effective and displayed synergy when combined with bedaquiline. Combinations of bedaquiline with azithromycin or ofloxacin produced greater reductions in bacterial burden than monotherapies. A three-drug regimen …
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From gut microbiome to pathogen genomics: Understanding antimicrobial resistance in Southeast Asia and Salmonella Paratyphi A
… this research addresses emerging resistance to azithromycin, a key treatment for enteric fever, linked to mutations in the acrB gene of the AcrAB-TolC efflux system. The impact of these mutations on resistance mechanisms was explored, highlighting their contribution to the growing threat of …
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Elucidating the chlamydial growth characteristics, infection factors, and host responses to persistent chlamydial infection in women
… and untreated infections. While treatment with azithromycin is highly effective, treatment failure does occur. The mechanisms of treatment failure and its effects on fertility are poorly understood. Unlike other bacterial pathogens, 𝘊. 𝘵𝘳𝘢𝘤𝘩𝘰𝘮𝘢𝘵𝘪𝘴 lacks stable genotypic resistance to macrolides. …
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The molecular epidemiology of Salmonella Typhi and applications for policy
… analyses of the first molecularly confirmed azithromycin-resistant S. Typhi isolated in Pakistan and India and put them into context with contemporaneous azithromycin-resistant isolates. I found that single point mutations in acrB (efflux pump) were emerging independently in these settings, …
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Effects of novel macrolide compounds on cell differentiation and barrier enhancement in colon epithelium
… er ekki enn þekkt. Þekkt er að sýklalyfið Azithromycin (AZM), sem er makrólíði, hafi þekjustyrkjandi áhrif sem ekki tengjast sýklalyfjavirkni þess. EpiEndo Pharmaceuticals hafa því þróað afleiður af AZM þar sem sýklalyfjahluti lyfsins hefur verið fjarlægður, og kallast þessar afleiður …
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Geographical Incidence of Antimicrobial Resistant Gonorrhea
… infections: Ceftriaxone injection and oral Azithromycin. These two medications are the last of many that show efficacy in treating gonorrhea, despite increasing resistance. Continued work researching geographic incidence similarities and correlations between geographical location, population …
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Optimization of Enantiopure tetrahydro-β-carbolines as Potent Antimalarials and Exploration of salicylic acid analogs for combating multidrug-resistant Neisseria gonorrhoeae
… threat level to public health. Dual therapy of azithromycin (AZM) and ceftriaxone has been the standard-of-care for treatment of gonococcal infections. However, due to increasing resistance to azithromycin (>33% in some regions) the CDC removed AZM from the treatment regimen for gonorrhea in …
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PERINATAL CELLS AS A TREATMENT FOR INFLAMMATORY LUNG DISEASES
… drugs such as corticosteroids, ibuprofen and azithromycin to mitigate the inflammatory response and improve lung function. However, the use of these drug regimens has been associated with serious adverse events such as growth retardation, and often presents challenges to establish precise …
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Investigating FDA-Approved Drugs for Treatment of Multidrug-Resistant Neisseria gonorrhoeae
… have a longer post-antibiotic effect than azithromycin. All three azoles cleared the burden of intracellular N. gonorrhoeae completely, which is superior to ceftriaxone. In conclusion, itraconazole, isavuconazole, and ravuconazole merit future investigation for the development of …
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Antimicrobial Polymers as Adjuvants/Synergists of Antibiotics to Combat Multidrug-Resistant Bacteria
… three antibiotics, doxycycline, rifampicin, and azithromycin, against wild type and MDR strains of Pseudomonas aeruginosa. Crucially, given the lower dosage of antimicrobial polymer used in these combination systems, the therapeutic index (also known as selectivity index), which is an indicator …
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Exploring a Novel Anti-Gonococcal Compound for Combating Drug-Resistant <i>Neisseria gonorrhoeae</i>
… mutants of N. gonorrhoeae CDC-181 (azithromycin-resistant) and WHO-X (ceftriaxone-resistant) were developed to evaluate the activity of potential anti-N. gonorrhoeae compounds. These mutants, CDC-181-rpsLA128G and WHO-X-rpsLA128G, successfully colonized the genital tracts of mice, …
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Antimicrobial resistance patterns of foodborne bacterial isolates from HIV/AIDS patients in Lusaka, Zambia.
… aurues isolates were 100% resistant to azithromycin and 90.90% resistant to methicillin. While Salmonella paratyphi isolate was 100% resistant to ampicillin, Sulfamethoxazole/trimethoprim and amoxicillin/clavulanic acid. MDR (multidrug resistance) was seen in 19.40% of the isolates and …
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Antimicrobial resistance patterns of foodborne bacterial isolates from HIV/AIDS patients in Lusaka, Zambia.
… aurues isolates were 100% resistant to azithromycin and 90.90% resistant to methicillin. While Salmonella paratyphi isolate was 100% resistant to ampicillin, Sulfamethoxazole/trimethoprim and amoxicillin/clavulanic acid. MDR (multidrug resistance) was seen in 19.40% of the isolates and …
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Antigen Trafficking within <em>Chlamydia trachomatis</em>-Infected Polarized Human Endometrial Epithelial Cells.
… in the presence and absence of the antibiotic azithromycin. These extra-inclusion vesicles were differentiated from Golgi vesicles and were shown to deliver chlamydial heat shock protein 60 (cHsp60)-homologs 2 and 3, but not homolog 1, to the infected cell surface. Examination of the …
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