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Showing 1 to 2 of 2 for “"azido-adenylylation"”.
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DNA enzymes for tyrosine PEGylation and azido-adenylylation of peptide and protein substrates
… enzyme first catalyzes the transfer of the 2′-azido-2′-deoxyadenosine 5′ monophosphoryl group (2′-Az-dAMP) from the analogous 5′-triphosphate (2′-Az-dATP) onto the tyrosine hydroxyl group (azido-adenylylation). Second, a particular modification of interest is attached to the azido group by …
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In vitro selection of deoxyribozymes for O-glycoside cleavage and for 3-nitrotyrosine modification
… selection of deoxyribozymes for 3-nitrotyrosine azido-adenylylation described in Chapter 4. Previous research had identified deoxyribozymes for tyrosine azido-adenylylation. The hydroxyl group of 3-nitrotyrosine is many orders of magnitude less reactive than that of tyrosine. In addition to …