Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"axotomy"”.
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Molecular Expression of Neuroprotective and Neurodestructive Signaling Systems Following Axotomy-Induced Target Disconnection: Relevance to ALS
… MN (FMN) cell loss following a facial nerve axotomy, compared to wild-type (WT) mice. Analysis of gene expression revealed that MN regenerative genes were expressed to a similar extent in SOD1 and WT mice however, differences were seen among genes expressed by the neuropil, namely …
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Diffuse Brain Injury Triggers Ultra-Rapid Perisomatic Traumatic Axonal Injury, Wallerian Change, and Non-Specific Inflammatory Responses
… leading to progressive swelling and delayed axotomy. DBI-mediated perisomatic axotomy does not result in acute neuronal death suggesting that delayed axotomy was responsible for this unanticipated response. To evaluate this hypothesis, we examined the spatiotemporal progression of …
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Immunoregulation of the central response to peripheral nerve injury: motoneuron survival and relevance to ALS
Facial nerve axotomy (FNA) in immunodeficient mice causes significantly more facial motoneuron (FMN) loss relative to wild type (WT), indicating that the immune system is neuroprotective. Further studies reveal that both CD4+ T cells and interleukin 10 (IL-10) act centrally to promote neuronal …
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Role of the Hu family of RNA-binding proteins in regulating acetylcholinesterase expression in excitatory cells
… myogenic differentiation and in vivo following axotomy of the rat superior cervical ganglion (SCG). Specifically, using a combination of molecular techniques we have investigated the role of AChE's 3'-untranslated region (UTR) and have identified both cis- and trans-acting factors that modulate …
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Axotomy and Regeneration of the Rat Facial Nerve: A Histomorphometric Study of the Facial Nucleus, Nerve and Orbicularis Oculi Muscle in an Experimental Model of Facial Paralysis
<p>One of the most unsettling sequela of facial paralysis (FP) is the loss of eye sphincter function and the blink response, leading to functional, psychological and aesthetic deficits. A medley of restorative microsurgery approaches have been employed in treating these deficits, however full …
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Diffuse axonal injury effect on myelinating cells and axons
… of myelinating oligodendrocytes or secondary axotomy. Cortical neurons are not able to remain healthy in culture to have their axons myelinated. Dorsal root ganglion (DRG) neurons have been shown to be myelinated by cortical oligodendrocytes in culture. An in vitro stretch injury model was …
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Effects of Electrical Stimulation and Testosterone in Translational Models of Facial Nerve Injury
… investigated. The extratemporal facial nerve axotomy model, in which the nerve is crushed at its exit from the skull, has been well established in the past and used to study the regeneration program of motoneurons. The present study uses this rat injury model to evaluate the therapeutic …
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Ciliary neurotrophic factor signaling in the magnocellular neurosecretory system : mechanisms of neuronal survival and sprouting
… signaling components appear to mediate the post-axotomy apoptotic cascade that results in the significant loss of oxytocinergic neurons following the organotypic culture preparation. Altogether, these novel data provide evidence of the mechanisms that CNTF utilizes to elicit its neuroprotective …
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The impact of reduced neuronal p75NTR expression on sensory neuron phenotype and associated glia
… in these cells in response to peripheral nerve axotomy was dramatically altered. More specifically, in response to p75NTR AS OGN infusion, there was a significant increase in SGC protein expression of the cytoskeletal protein GFAP and p75NTR, along with a significant decrease in expression of …
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Promoting Central Nervous System Regeneration by Targeting Intracellular Pathways
… axons after $\textit{in vitro}$ laser axotomy. Furthermore, overexpression of wild-type and phospho-protrudin in the retina resulted in enhanced axon regeneration in a mouse model of optic nerve crush 2 weeks after injury. Live-cell imaging experiments revealed that this increased …
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Regulatory Architecture of Non-Apoptotic Cell Death Program in C. Elegans
… degeneration of axon distal segments following axotomy, and some developmental and pathological cell death events in vertebrates resemble the morphology of the dying linker cell. Thus, the molecular mechanism governing linker cell death may be conserved; however, neither the initiating death …
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Axon Degeneration and the Schwann Cell Early Injury Response: A Study in Mouse and Zebrafish
… the rate of axon degeneration after laser axotomy of the peripheral lateral line nerve in wildtype, as well as in sarm1 mutant animals. I show a characteristic delay in axon degeneration in sarm1 mutant zebrafish, while their myelination is normal. I then performed cell specific …
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Neurotrophins and neurotrophin receptors in adult primary sensory neurons
… of trkB and trkC mRNA is reduced following axotomy, suggesting a neurotrophin-deficient state and a role for these molecules in promoting normal phenotype. Secondly, neuronal BDNF was characterized in intact, axotomized and NGF-infusedDRG using 'in situ' hybridization and …
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Analysis of nerve terminal dysfunction in autoimmune neuropathy
… on an intact axon as it is retained following axotomy. At 3 months, minor remodelling of the NMJ is seen, and is more pronounced at one year. Repeat antibody exposure within 48 hours does not injure returning processes, or delay repopulation. Instead, extra-junctional TSC processes are formed, …
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Gene therapy for axon regeneration
… cortical neurons that underwent in vitro laser axotomy. Chapter IV aimed to identify the best method to deliver transgenes into the corticospinal tract by using AAVs. The choice of serotype and promoter has a crucial impact on gene therapy as it can ultimately depict whether it will be …
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Neuronale und gliale Reaktionen nach Fimbria -Fornix-Durchtrennung : zur Rolle von CNTF und LIF
CNTF und LIF zeigen neuroprotektive Effekte auf axotomierte septohippocampale Projektionsneurone des medialen Septums (MS) nach Fimbria-Fornix-Durchtrennung. Neuere Untersuchungen lassen eine zelltyp-spezifische Wirkung der endogenen Cytokine auf GABAerge bzw. cholinerge MS-Neurone nach Axotomie …
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Exploring the role of programmed axon death genes SARM1 and NMNAT2 in human disease
Programmed axon death (PAD) is an evolutionary-conserved path of axon destruction initiated by injury and disease. Two proteins are known to profoundly influence axonal health: the pro-death SARM1 and its upstream regulator, the pro-survival NMNAT2. Notably, complete removal of SARM1 has been shown …
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Exploring SARM1 as a target to delay programmed axon degeneration
Programmed axon degeneration (Wallerian degeneration) can occur after physical injury, inhibition of axon transport, exposure to neurotoxic compounds, and in diseases involving mitochondrial or metabolic dysfunction. There is increasing evidence that this pathway can be activated in human painful …